Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Net product sales	$ 798,524	$ 665,791	$ 2,251,495	$ 1,902,107
Other revenue	582	846	1,765	1,073
Total revenues	799,106	666,637	2,253,260	1,903,180
Cost of sales	71,095	54,057	190,708	175,463
Operating expenses:
Research and development	195,687	165,664	551,288	518,437
Selling, general and administrative	230,128	212,520	694,491	621,019
Amortization of purchased intangible assets	82,036	36,608	242,185	36,608
Change in fair value of contingent consideration	40,290	29,684	30,676	45,707
Acquisition-related costs	0	6,075	2,313	35,852
Restructuring expenses	564	7,461	1,741	30,737
Total operating expenses	548,705	458,012	1,522,694	1,288,360
Operating income	179,306	154,568	539,858	439,357
Other income and expense:
Investment income	4,626	1,967	8,049	7,077
Interest expense	(24,807)	(19,971)	(72,490)	(24,593)
Foreign currency (loss) gain	(1,011)	2,795	(3,740)	1,755
Income before income taxes	158,114	139,359	471,677	423,596
Income tax provision	63,776	323,116	165,113	345,815
Net income (loss)	$ 94,338	$ (183,757)	$ 306,564	$ 77,781
Earnings (loss) per common share
Basic	$ 0.42	$ (0.81)	$ 1.37	$ 0.37
Diluted	$ 0.42	$ (0.81)	$ 1.35	$ 0.37
Shares used in computing earnings per common share
Basic	224,180	226,228	224,454	209,373
Diluted	226,088	226,228	226,560	211,808