Restructuring

In connection with the acquisition and integration of Synageva in 2015, we recorded a restructuring benefit of $924 for the three months ended March 31, 2016 primarily related to changes in estimates associated with employee costs. We expect to pay all remaining accrued amounts related to this restructuring activity by the end of 2016.

In the fourth quarter 2014, we announced plans to move our European headquarters from Lausanne to Zurich, Switzerland. The relocation of our European headquarters supports our operational needs based on growth in the European region. During the three months ended March 31, 2016, we incurred additional restructuring costs of $1,646. We expect to pay all remaining accrued amounts related to this restructuring activity by the end of 2016.

The following table presents a reconciliation of the restructuring reserve recorded within accrued expenses on the Company's condensed consolidated balance sheet for the three months ended March 31, 2016:



	Employee Separation Costs			Contract Termination Costs			Other Costs			Total
Liability, beginning of period	$	6,390		$	682		$	169		$	7,241
Restructuring expenses	—			35			417			452
Cash settlements	(3,806		)	(508		)	(570		)	(4,884		)
Adjustments to previous estimates	(1,148		)	1,418			—			270
Liability, end of period	$	1,436		$	1,627		$	16		$	3,079

The restructuring reserve of $3,079 is recorded in accrued expenses on the Company's condensed consolidated balance sheet as of March 31, 2016.