8-K

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

_______________________

FORM 8-K

CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(D) OF
THE SECURITIES EXCHANGE ACT OF 1934

Date of report (Date of earliest event reported): January 29, 2015

ALEXION PHARMACEUTICALS, INC.

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(Exact name of registrant as specified in its charter)

Delaware	000-27756	13-3648318
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(State or other jurisdiction of of incorporation or organization)	(Commission File Number)	(I.R.S. Employer Identification No.)

352 Knotter Drive, Cheshire, Connecticut 06410

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(Address of Principal Executive Offices) (Zip Code)

Registrant's telephone number, including area code: (203) 272-2596

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):
¨	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
¨	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
¨	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
¨	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 2.02Results of Operations and Financial Condition.

On January 29, 2015, Alexion Pharmaceuticals, Inc. issued a press release relating to its results of operations and financial conditions for the quarter and year ended December 31, 2014. A copy of the press release is furnished as Exhibit 99.1 to this Form 8-K.

The attached press release contains both U.S. Generally Accepted Accounting Principles, or GAAP, and non-GAAP financial measures. The non-GAAP financial measures exclude the impact of share-based compensation expense, acquisition-related costs, upfront and milestone payments related to license and collaboration agreements, intangible asset impairments, restructuring expenses, amortization of purchased intangible assets, change in contingent liability from intellectual property settlements, and non-cash taxes. Reconciliations between non-GAAP and GAAP financial measures are included in the press release set forth as Exhibit 99.1 furnished to this Form 8-K. Alexion's management utilizes non-GAAP financial information to provide a useful measure of comparative operating performance of Alexion. The non-GAAP financial measures are supplemental to and not a substitute for, measures of financial performance prepared in accordance with GAAP.

Item 5.02    Departure of Directors or Principal Officers; Election of Directors; Appointment of Principal Officers.

On January 29, 2015, Alexion Pharmaceuticals, Inc. announced the appointment of David L. Hallal, 48, as Chief Executive Officer effective April 1, 2015. Mr. Hallal has served as Alexion’s Chief Operating Officer and has been a member of the Board of Directors since September 2014. Upon becoming Chief Executive Officer, Mr. Hallal will no longer serve as Chief Operating Officer. Mr. Hallal joined Alexion in 2006. He served as Alexion’s Executive Vice President and Chief Commercial Officer from October 2012 until September 2014, Senior Vice President, Global Commercial Operations from May 2010 until October 2012 and in other senior commercial positions with Alexion from June 2006 to May 2010. Additional biographical information about Mr. Hallal is contained in Alexion's Annual Report on Form 10-K for the year ended December 31, 2013 and filed with the SEC on February 10, 2014.

Mr. Hallal will succeed Leonard Bell, M.D., Chairman and Chief Executive Officer, who will retire as Chief Executive Officer effective April 1, 2015, and continue to serve as Chairman of the Board. Dr. Bell was the principal founder of Alexion in 1992 and has served as CEO for the past 23 years.

A copy of Alexion's press release announcing Mr. Hallal's appointment and Dr. Bell's retirement is filed as Exhibit 99.2 to this Current Report on Form 8-K. A description of Mr. Hallal’s compensation arrangements with Alexion is contained in Alexion's definitive proxy statement filed with the Securities and Exchange Commission on April 23, 2014 and is incorporated herein by reference.

Item 9.01Financial Statements and Exhibits.

(d)    Exhibits

99.1 Press Release issued by Alexion Pharmaceuticals, Inc. on January 29, 2015 relating to its results of operations and financial conditions for the quarter and year ended December 31, 2014.

99.2 Press Release issued by Alexion Pharmaceuticals, Inc. on January 29, 2015 relating to the appointment of Mr. Hallal as Chief Executive Officer and the retirement of Dr. Bell.

Signature

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: January 29, 2015	ALEXION PHARMACEUTICALS, INC.
	By:     /s/ Michael V. Greco
	Name:    Michael V. Greco
	Title:    Vice President of Law and Corporate Secretary

EX-99.1

Alexion Reports Fourth Quarter and Full Year 2014 Results and Provides Financial Guidance for 2015

- Soliris® (eculizumab) Net Product Sales Increased 44 Percent

to $2.234 Billion -

- Soliris Net Product In-Year Sales Increased 38 Percent

to $2.146 Billion -

- Steady Soliris PNH Growth Worldwide; aHUS Global Launch Progresses -

- Regulatory Submissions for Asfotase Alfa in the U.S., Europe and Japan Completed -

- Three Eculizumab Registration Programs Enrolling in DGF, NMO and MG -

- Two Next-Generation Soliris Phase 1 Trials Underway with ALXN1210 and ALXN5500 -

- 17 Pre-clinical Development Programs Spanning Diverse Modalities and Therapeutic Areas -

Full Year 2014 Financial Highlights:

• 2014 net product sales increased 44 percent to $2.234 billion, compared to $1.551 billion in 2013. Excluding the impact of $88 million for reimbursement of prior year shipments, 2014 net product sales increased 38 percent to $2.146 billion.

• 2014 GAAP EPS increased to $3.26 per share, compared to 2013 GAAP EPS of $1.27 per share.

• 2014 non-GAAP EPS increased 69 percent to $5.21 per share, compared to 2013 non-GAAP EPS of $3.08 per share. Excluding $0.37 per share related to reimbursement of prior year shipments, 2014 non-GAAP EPS increased 57 percent to $4.84 per share.

Fourth Quarter 2014 Financial Highlights

• Q42014 net product sales increased 36 percent to $599 million, compared to $442 million in Q42013.

• Q42014 GAAP EPS increased to $0.76 per share, compared to a Q4 2013 GAAP net loss of $0.10 per share.

• Q4 2014 non-GAAP EPS increased 49 percent to $1.30 per share, compared to Q4 2013 non-GAAP EPS of $0.87 per share.

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CHESHIRE, Conn., January 29, 2015-- Alexion Pharmaceuticals, Inc. (NASDAQ: ALXN) today announced financial results for the quarter and year ended December 31, 2014. For the three months ended December 31, 2014, the Company reported net product sales of Soliris^® (eculizumab) of $599 million, compared to $442 million for the same period in 2013. The year-on-year increase in Q4 net product sales of 36 percent reflected steady additions of new patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) commencing Soliris treatment.

Alexion is serving patients with PNH and aHUS in 50 countries. Both PNH and aHUS are severe and life-threatening ultra-rare disorders caused by chronic uncontrolled complement activation.

“In 2014, we provided Soliris to an increasing number of patients with PNH and aHUS worldwide while simultaneously reaching several significant milestones across our pipeline. Most notably, we completed the regulatory submissions in the U.S., Europe and Japan for asfotase alfa as a potential treatment for patients with HPP, commenced registration trials for eculizumab in patients with DGF, NMO and MG, and initiated clinical development of our first two molecules from our next-generation Soliris portfolio,” said Leonard Bell, M.D., Chairman and Chief Executive Officer of Alexion. “Throughout 2015, we will focus on serving more patients with PNH and aHUS globally while also preparing for the launch of asfotase alfa. At the same time, we will advance our lead development programs as we drive toward as many as seven potential new indications or product approvals through 2018.”

Full Year 2014 GAAP Financial Results

Alexion reported GAAP net income of $657 million, or $3.26 per share, in 2014 compared to 2013 GAAP net income of $253 million, or $1.27 per share. Full year 2014 GAAP EPS included $0.31 per share related to reimbursement of prior year shipments.

Alexion's GAAP operating expenses for the full year 2014 were $1.191 billion, compared to $846 million in 2013. GAAP research and development (R&D) expenses for 2014 were $514 million, compared to $317 million in 2013. GAAP selling, general and administrative (SG&A) expenses for 2014 were $630 million, compared to $490 million for the prior year.

Full Year 2014 Non-GAAP Financial Results

Alexion's non-GAAP operating results are GAAP operating results adjusted for the impact of certain items described in the accompanying tables. A full reconciliation of GAAP results to non-GAAP results is included later in this press release.

The Company reported non-GAAP net income of $1.066 billion in 2014, or $5.21 per share, compared to non-GAAP net income of $624 million, or $3.08 per share, in 2013. Full year 2014 non-GAAP EPS included $0.37 per share related to reimbursement of prior year shipments.

Alexion's non-GAAP operating expenses for the full year 2014 were $924 million, compared to $719 million for 2013. Non-GAAP R&D expenses for 2014 were $368 million, compared to $279 million for the prior year. Non-GAAP SG&A expenses for 2014 were $556 million, compared to $441 million in 2013.

Fourth Quarter GAAP Financial Results

Alexion reported GAAP net income of $153 million, or $0.76 per share, in Q4 2014, compared to a GAAP net loss of $19 million, or $0.10 per share, in Q4 2013. Q4 2013 GAAP results were impacted by $96 million, or $0.48 per share, related to a non-cash tax expense associated with centralizing certain business operations

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On a GAAP basis, operating expenses for Q4 2014 were $346 million, compared to $252 million for Q4 2013. GAAP R&D expenses for Q4 2014 were $129 million, compared to $86 million for Q4 2013. GAAP SG&A expenses were $184 million for Q4 2014, compared to $135 million for Q4 2013.

Fourth Quarter Non-GAAP Financial Results

The Company reported non-GAAP net income of $266 million, or $1.30 per share, in Q4 2014, compared to non-GAAP net income of $178 million, or $0.87 per share, in Q4 2013.

Alexion's non-GAAP operating expenses for Q4 2014 were $272 million, compared to $202 million for Q4 2013. Non-GAAP R&D expenses for Q4 2014 were $108 million, compared to $80 million for Q4 2013. Non-GAAP SG&A expenses for Q4 2014 were $164 million, compared to $122 million for Q4 2013.

Balance Sheet:

As of December 31, 2014, the Company had $1.962 billion in cash, cash equivalents and marketable securities compared to $1.515 billion at December 31, 2013.

Research and Development Progress

Alexion has development programs underway with highly innovative product candidates that have the potential to become transformative therapies for patients with severe and ultra-rare disorders.

Asfotase Alfa

• Alexion completed regulatory submissions in the United States, Europe and Japan for asfotase alfa for the treatment of hypophosphatasia (HPP).

• Alexion will initiate a clinical trial of asfotase alfa in adults with severe HPP.

Ultra-Rare Disease Programs With Eculizumab

• Kidney Transplant: Antibody-Mediated Rejection (AMR) - Alexion reported that the Phase 2 living-donor AMR prevention trial did not meet its primary endpoint. Deceased-donor Phase 2 trial data are expected in the second half of 2015. Alexion has announced plans to commence an AMR treatment trial.

• Kidney Transplant: Delayed Graft Function (DGF)- Alexion is enrolling patients in a single, multinational DGF prevention registration trial.

• Neurology: Neuromyelitis Optica (NMO) - Enrollment and dosing are ongoing in a single, multinational, placebo-controlled, registration trial in relapsing NMO.

• Neurology: Myasthenia Gravis (MG) - Enrollment and dosing are ongoing in a single, multinational, placebo-controlled, registration trial in refractory MG.

• Next-Generation Soliris Development Programs - Alexion initiated clinical development of ALXN1210 and ALXN5500, the first two molecules in the Company’s innovative portfolio of next-generation Soliris candidates.

Ultra-Rare Disease Programs with Additional Highly Innovative Therapeutics

• ALXN1007 - Alexion commenced dosing in two Phase 2 proof-of-concept studies of ALXN1007, a novel anti-inflammatory antibody, in patients with graft versus host disease

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involving the lower gastrointestinal tract (GI-GVHD) and antiphospholipid syndrome (APS), two severe, auto-immune diseases with potentially life-threatening complications.

• cPMP Replacement Therapy (ALXN 1101) - A synthetic cPMP bridging study in patients with molybdenum cofactor deficiency (MoCD) Type A is ongoing and enrollment in a natural history study is also ongoing. Alexion received Breakthrough Therapy designation for its cPMP replacement therapy.

2015 Financial Guidance

In 2015, worldwide net product sales are expected to be within a range of $2.55 to $2.6 billion, which includes an approximately negative 5 percent, or $135 million, foreign exchange impact compared to 2014 exchange rates. Non-GAAP earnings per share for the year are expected to be $5.60 to $5.80, which includes an approximately $0.30 negative foreign exchange impact compared to 2014 exchange rates. 2015 guidance is based on current exchange rates remaining unchanged.

On a non-GAAP basis, 2015 financial guidance is as follows:

Cost of sales	8% to 9% of net product sales
Research and development	$440 to $470 million
Selling, general and administrative	$620 to $650 million
Effective tax rate	7% to 9%
Diluted shares outstanding	205 million

Conference Call/Webcast Information

Alexion will host a conference call/audio webcast to discuss matters mentioned in this release. The call is scheduled for today, January 29, at 10:00 a.m., Eastern Time. To participate in this call, dial 1-800-768-6569 (USA) or +1-785-830-7992 (International), passcode 6130985, shortly before 10:00 a.m., Eastern Time. A replay of the call will be available for a limited period following the call, beginning at 1:00 p.m., Eastern Time. The replay number is 1-888-203-1112 (USA) or +1-719-457-0820 (International), passcode 6130985. The audio webcast can be accessed on the Investor page of Alexion’s website at: http://ir.alexionpharm.com

About Soliris^® (eculizumab)

Soliris is a first-in-class terminal complement inhibitor developed from the laboratory through regulatory approval and commercialization by Alexion. Soliris is approved in the U.S. (2007), European Union (2007), Japan (2010) and other countries as the first and only treatment for patients with paroxysmal nocturnal hemoglobinuria (PNH) to reduce hemolysis. PNH is a debilitating, ultra-rare and life-threatening blood disorder, characterized by complement-mediated hemolysis (destruction of red blood cells). Soliris is also approved in the U.S. (2011), European Union (2011), Japan (2013) and other countries as the first and only treatment for patients with atypical hemolytic uremic syndrome (aHUS) to inhibit complement-mediated thrombotic microangiopathy, or TMA (blood clots in small vessels). aHUS is a debilitating, ultra-rare and life-threatening genetic disorder characterized by complement-mediated TMA. Soliris is not indicated for the treatment of patients with Shiga-toxin E. coli-related hemolytic uremic syndrome (STEC-HUS). For the breakthrough medical innovation in complement inhibition, Alexion and Soliris have received some of the pharmaceutical industry's highest honors: the Prix Galien USA (2008, Best Biotechnology Product) and France (2009, Rare Disease Treatment).

More information including the full U.S. prescribing information on Soliris is available at www.soliris.net.

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About Alexion

Alexion is a biopharmaceutical company focused on serving patients with severe and rare disorders through the innovation, development and commercialization of life-transforming therapeutic products. Alexion is the global leader in complement inhibition and has developed and markets Soliris^® (eculizumab) as a treatment for patients with PNH and aHUS, two debilitating, ultra-rare and life-threatening disorders caused by chronic uncontrolled complement activation. Soliris is currently approved in nearly 50 countries for the treatment of PNH, and in nearly 40 countries for the treatment of aHUS. Alexion is evaluating other potential indications for Soliris in additional severe and ultra-rare disorders beyond PNH and aHUS, and is developing other highly innovative biotechnology product candidates across multiple therapeutic areas. This press release and further information about Alexion can be found at www.alexion.com.

[ALXN-E]

This news release contains forward-looking statements, including statements related to guidance regarding anticipated financial results for 2015, assessment of the Company's financial position and commercialization efforts, medical benefits and commercial potential for Soliris for PNH and aHUS and other potential indications, medical and commercial potential of Alexion's complement-inhibition technology and other technologies, commercial potential associated with the expected launch of asfotase alfa in 2015, and plans for clinical programs for each of our product candidates. Forward-looking statements are subject to factors that may cause Alexion's results and plans to differ from those expected, including for example, decisions of regulatory authorities regarding marketing approval or material limitations on the marketing of Soliris for PNH and aHUS and other potential indications or asfotase alfa for HPP, delays, interruptions or failures in the manufacture and supply of Soliris and our product candidates, progress in establishing and developing commercial infrastructure, failure to satisfactorily address the issues raised by the FDA in regulatory correspondence, the possibility that results of clinical trials are not predictive of safety and efficacy results of Soliris in broader patient populations in the disease studied or other diseases, the risk that strategic transactions will not result in short-term or long-term benefits, the possibility that current results of commercialization are not predictive of future rates of adoption of Soliris in PNH, aHUS or other diseases, the possibility that clinical trials of our product candidates could be delayed or that additional research and testing is required by regulatory agencies, the adequacy of our pharmacovigilance and drug safety reporting processes, the risk that third party payors (including governmental agencies) will not reimburse or continue to reimburse for the use of Soliris at acceptable rates or at all, the risk that estimates regarding the number of patients with PNH, aHUS or other diseases are inaccurate, and a variety of other risks set forth from time to time in Alexion's filings with the U.S. Securities and Exchange Commission, including but not limited to the risks discussed in Alexion's Quarterly Report on Form 10-Q for the period ended September 30, 2014 and in our other filings with the U.S. Securities and Exchange Commission. Alexion does not intend to update any of these forward-looking statements to reflect events or circumstances after the date hereof, except when a duty arises under law.

In addition to financial information prepared in accordance with GAAP, this news release also contains non-GAAP financial measures that Alexion believes, when considered together with the GAAP information, provide investors and management with supplemental information relating to performance, trends and prospects that promote a more complete understanding of our operating results and financial position during different periods. The non-GAAP results exclude the impact of the following GAAP items: share-based compensation expense, acquisition-related costs, amortization of purchased intangible assets, upfront and milestone payments related to license and collaboration agreements, intangible asset impairments, restructuring expense, and non-cash taxes. These non-GAAP financial measures are not intended to be considered in isolation or as a substitute for, or superior to, the financial measures prepared and presented in accordance with GAAP and should be reviewed in conjunction with the relevant GAAP financial measures. Please refer to the attached Reconciliation of GAAP to Non-GAAP Financial Results for explanations of the amounts adjusted to arrive at non-GAAP net income and non-GAAP earnings per share amounts for the three and twelve month periods ended December 31, 2014 and 2013.

- TABLES FOLLOW -

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Alexion Contacts:

Media

Irving Adler, 203-271-8210

Executive Director, Corporate Communications

Kim Diamond, 203-439-9600

Senior Director, Corporate Communications

Investors

Elena Ridloff, CFA, 203-699-7722

Executive Director, Investor Relations

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ALEXION PHARMACEUTICALS, INC.
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
(in thousands, except per share amounts)
(unaudited)
	Three months ended					Twelve months ended
	December 31					December 31
	2014		2013			2014			2013
Net product sales	$	599,476	$	441,909		$	2,233,733		$	1,551,346
Cost of sales:
Cost of sales	49,439		51,552			173,862			168,375
Change in contingent liability from intellectual property settlements	—		—			—			9,181
Total cost of sales	49,439		51,552			173,862			177,556
Operating expenses:
Research and development	129,110		85,785			513,782			317,093
Selling, general and administrative	183,776		134,819			630,209			489,720
Acquisition-related costs	10,041		(1,945		)	20,295			5,029
Impairment of intangible assets	8,050		33,521			11,514			33,521
Restructuring expenses	15,365		—			15,365			—
Amortization of purchased intangible assets	—		105			—			417
Total operating expenses	346,342		252,285			1,191,165			845,780
Operating income	203,695		138,072			868,706			528,010
Other expense	1,646		(95		)	3,401			(1,741		)
Income before income taxes	205,341		137,977			872,107			526,269
Income tax provision	52,009		156,969			215,195			273,374
Net income (loss)	$	153,332	$	(18,992	)	$	656,912		$	252,895
Earnings (loss) per common share
Basic	$	0.77	$	(0.10	)	$	3.32		$	1.29
Diluted	$	0.76	$	(0.10	)	$	3.26		$	1.27
Shares used in computing earnings (loss) per common share
Basic	198,676		196,430			198,103		—	195,532
Diluted	201,732		196,430			201,623			199,712

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ALEXION PHARMACEUTICALS, INC.
RECONCILIATION OF GAAP TO NON-GAAP FINANCIAL RESULTS
(in thousands, except per share amounts)
(unaudited)
	Three months ended					Twelve months ended
	December 31					December 31
	2014		2013			2014		2013
Net income (loss) reconciliation:
GAAP net income (loss)	$	153,332	$	(18,992	)	$	656,912	$	252,895
Share-based compensation expense	33,840		19,794			$	114,461	$	76,203
Acquisition-related costs (1)	10,041		(1,945		)	20,295		5,029
Upfront and milestone payments related to license and collaboration agreements (2)	8,000		—			109,925		14,500
Impairment of intangible assets (3)	8,050		33,521			11,514		33,521
Restructuring expenses (4)	15,365		—			15,365		—
Amortization of purchased intangible assets	—		105			—		417
Change in contingent liability from intellectual property settlements	—		—			—		9,181
Non-cash taxes (5)	37,355		145,266			137,449		232,460
Non-GAAP net income	$	265,983	$	177,749		$	1,065,921	$	624,206
GAAP earnings (loss) per share - diluted	$	0.76	$	(0.10	)	$	3.26	$	1.27
Non-GAAP earnings per share - diluted	$	1.30	$	0.87		$	5.21	$	3.08
Shares used in computing diluted earnings (loss) per share (GAAP)	201,732		196,430			201,623		199,712
Shares used in computing diluted earnings per share (non-GAAP)	204,270		203,586			204,459		202,943

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	Three months ended						Twelve months ended
	December 31						December 31
	2014			2013			2014			2013
Cost of sales reconciliation:
GAAP cost of sales	$	49,439		$	51,552		$	173,862		$	177,556
Share-based compensation expense	(1,268		)	(865		)	(4,174		)	(3,214		)
Change in contingent liability from intellectual property settlements	—			—			—			(9,181		)
Non-GAAP cost of sales	$	48,171		$	50,687		$	169,688		$	165,161
Research and development reconciliation:
GAAP research and development	$	129,110		$	85,785		$	513,782		$	317,093
Share-based compensation expense	(12,829		)	(5,944		)	(36,203		)	(23,905		)
Upfront and milestone payments related to license and collaboration agreements (2)	(8,000		)	—			(109,925		)	(14,500		)
Non-GAAP research and development	$	108,281		$	79,841		$	367,654		$	278,688
Selling, general and administrative reconciliation:
GAAP selling, general and administrative	$	183,776		$	134,819		$	630,209		$	489,720
Share-based compensation expense	(19,743		)	(12,985		)	(74,084		)	(49,084		)
Non-GAAP selling, general and administrative	$	164,033		$	121,834		$	556,125		$	440,636
Income tax provision reconciliation:
GAAP income tax provision	$	52,009		$	156,969		$	215,195		$	273,374
Non-cash taxes (5)	(37,355		)	(145,266		)	(137,449		)	(232,460		)
Non-GAAP income tax provision	$	14,654		$	11,703		$	77,746		$	40,914

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(1	)	The following table summarizes acquisition-related costs:
			Three months ended					Twelve months ended
			December 31					December 31
			2014		2013			2014		2013
		Separately-identifiable employee costs	$	—	$	—		$	—	$	248
		Professional fees	—		—			—		775
		Changes in fair value of contingent consideration	10,041		(1,945		)	20,295		4,006
			$	10,041	$	(1,945	)	$	20,295	$	5,029
(2	)	In December 2014, the Company entered into an agreement that provides an option to purchase drug products for clinical development and commercialization. The Company recorded research and development expense for an upfront payment of $8 million.
(3	)	During the three and twelve months ended December 31, 2014, the Company recorded impairment charges related to early stage development assets.
(4	)	In October 2014, the Company announced plans to move it's European headquarters from Lausanne to Zurich, Switzerland. As a result of this action, the Company recorded restructuring expense of $15 million during the three months ended December 31, 2014 related to employee costs.
(5	)	Non-cash taxes represents the adjustment from GAAP tax expense to the amount of taxes that are payable in cash in the current period.

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ALEXION PHARMACEUTICALS, INC.
CONDENSED CONSOLIDATED BALANCE SHEETS
(in thousands)
(unaudited)
	December 31		December 31
	2014		2013
Cash and cash equivalents	$	943,999	$	529,857
Marketable securities	1,017,567		984,994
Trade accounts receivable, net	432,888		421,752
Inventories	176,441		102,602
Deferred tax assets, current	35,733		41,432
Other current assets	189,401		106,220
Property, plant and equipment, net	392,248		201,109
Intangible assets, net	587,046		609,719
Goodwill	254,073		254,073
Deferred tax assets, noncurrent	34,939		3,394
Other noncurrent assets	137,627		62,544
Total assets	$	4,201,962	$	3,317,696
Accounts payable and accrued expenses	439,248		423,940
Current portion of long-term debt	48,000		48,000
Other current liabilities	119,492		110,489
Long-term debt, less current portion	9,500		65,000
Contingent consideration, noncurrent	116,425		106,744
Deferred tax liabilities, noncurrent	7,046		101,241
Other noncurrent liabilities	160,233		80,203
Total liabilities	899,944		935,617
Total stockholders' equity	3,302,018		2,382,079
Total liabilities and stockholders' equity	$	4,201,962	$	3,317,696

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		ALEXION PHARMACEUTICALS, INC.
		NET PRODUCT SALES BY SIGNIFICANT GEOGRAPHIC REGION
		(in thousands)
		(unaudited)
			Twelve months ended
			December 31
			2014		2013		% Variance
		United States	$	153,332	$	561,405	30	%
		Europe (1)	836,134		514,987		62	%
		Asia Pacific	244,059		203,538		20	%
		Other	423,451		271,416		56	%
		Total net product sales	$	2,233,733	$	1,551,346	44	%
(1	)	In March 2014, we entered into an agreement with the French government which positively impacted prospective reimbursement of Soliris and also provided for reimbursement for shipments made in years prior to January 1, 2014. As a result of the agreement, in the first quarter of 2014, we recognized $88 million of net product sales from Soliris in France relating to years prior to January 1, 2014.

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EX-99.2

Alexion Appoints David L. Hallal as Chief Executive Officer, Effective April 1, 2015

Leonard Bell, M.D. Announces His Plans to Retire as CEO

Dr. Bell to Continue as Chairman

Cheshire, CT - January 29, 2015 - Alexion Pharmaceuticals, Inc. (Nasdaq: ALXN) today announced that its Board of Directors has appointed David L. Hallal as the Company’s Chief Executive Officer (CEO), effective April 1, 2015. Mr. Hallal currently serves as Alexion’s Chief Operating Officer (COO) and is a Director of the Board. He will succeed Leonard Bell, M.D., Chairman and CEO, who will retire as CEO and continue to serve as Chairman of the Board. Dr. Bell was the principal founder of Alexion in 1992 and has served as CEO for the past 23 years.

Mr. Hallal, 48, has more than 25 years of experience in the biopharmaceutical industry. Since joining Alexion in 2006 to initiate commercial operations, he has served in key leadership positions of increasing responsibility, including as the Company’s first Chief Commercial Officer, and was appointed COO and to the Board of Directors in 2014. Mr. Hallal has played a principal role in leading many of the Company’s key growth initiatives, including the highly successful launches of Soliris^® (eculizumab) in PNH and aHUS and the building of Alexion’s 50-country operating platform.

“Since founding Alexion in 1992, Lenny has taken Alexion from a start-up venture to an S&P 500 company that is recognized as one of the most successful and innovative biotechnology companies in the world. Lenny’s vision, leadership and dedication to serving patients with rare and devastating diseases have positively transformed the lives of patients and their families around the world,” said R. Douglas Norby, Lead Director of Alexion’s Board of Directors. “This planned leadership transition comes at a time of great strength at Alexion, given our growing revenues, exceptional development pipeline, and robust balance sheet. David’s outstanding performance and leadership at Alexion uniquely positions him to drive the Company’s growth as a multi-product, global organization.”

“As Alexion serves more patients with Soliris around the world and advances the most robust pipeline in our history, the time is right for the Company, and me personally, for David to become CEO in line with our succession plan,” said Dr. Bell. “David has demonstrated outstanding leadership over the past decade at Alexion and has been instrumental in driving the performance and building the culture for which we are known. As we have been increasingly sharing responsibilities over the last several years, I am very pleased that David will now lead Alexion in its relentless focus on serving more patients with severe and rare disorders worldwide. I look forward to continuing to guide the Board and advising the Company on strategic matters in my role as Chairman.”

“Lenny is an inspirational leader who hasdeveloped a company-wide commitment to innovation, created our patient-focused culture, and instilled exquisite discipline and operational excellence that have driven our remarkable success over the last two decades,” said Mr. Hallal. “I am deeply honored by this appointment and the confidence of the Board. Alexion is poised for the next stage of its global growth and innovation, and I look forward to leading our deeply experienced executive team and talented and dedicated staff as we serve patients around the world.”

About Alexion

Alexion is a biopharmaceutical company focused on serving patients with severe and rare disorders through the innovation, development and commercialization of life-transforming therapeutic products. Alexion is the global leader in complement inhibition and has developed and markets Soliris^® (eculizumab) as a treatment for patients with PNH and aHUS, two debilitating, ultra-rare and life-threatening disorders caused by chronic uncontrolled complement activation. Soliris is currently approved in nearly 50 countries for the treatment of PNH and in nearly 40 countries for the treatment of aHUS. Alexion is evaluating other potential indications for Soliris in additional severe and ultra-rare disorders beyond PNH and aHUS, and is developing other highly innovative biotechnology product candidates across multiple therapeutic areas. This press release and further information about Alexion can be found at www.alexion.com.

Safe Harbor Statement

This news release contains forward-looking statements. Forward-looking statements are subject to factors that may cause Alexion’s results and plans to differ from those expected, including for example, decisions of regulatory authorities regarding marketing approval or material limitations on the marketing of Soliris for its current or potential new indications, and a variety of other risks set forth from time to time in Alexion’s filings with the Securities and Exchange Commission, including but not limited to the risks discussed in Alexion’s Quarterly Report on Form 10-Q for the period ended September 30, 2014, and in Alexion’s other filings with the Securities and Exchange Commission. Alexion does not intend to update any of these forward-looking statements to reflect events or circumstances after the date hereof, except when a duty arises under law.

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Alexion Contacts:

Media

Irving Adler, 203-271-8210

Executive Director, Corporate Communications

or

Kim Diamond, 203-439-9600

Senior Director, Corporate Communications

or

Investors

Elena Ridloff, CFA, 203-699-7722

Executive Director, Investor Relations