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Description of Business and Significant Accounting Policies - Additional Information (Detail)
1 Months Ended 3 Months Ended
Jan. 31, 2022
USD ($)
Jun. 30, 2021
USD ($)
Apr. 30, 2021
USD ($)
Mar. 31, 2021
USD ($)
Mar. 31, 2022
USD ($)
Segment
Contract
Dec. 31, 2021
USD ($)
Aug. 31, 2019
USD ($)
Jul. 01, 2013
USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]                
Accumulated deficit         $ (3,156,067,000) $ (3,130,069,000)    
Principal amount         288,400,000      
Cash and cash equivalents       $ 247,833,000 67,243,000 124,184,000    
Short-term investments         95,203,000 79,932,000    
Long-term investments         $ 70,542,000 56,619,000    
Debt issuance amount       $ 230,000,000.0        
Debt issuance percentage       2.50%        
Number of operating segment | Segment         1      
Convertible Promissory Note | Thirona Bio, Inc.                
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]                
Investment securities $ 5,000.0 $ 3,000.0     $ 6,900,000 3,000,000.0    
Proceeds from investment securities $ 5,000.0 $ 3,000.0            
Maturity date   2023-12            
Interest rate   6.00%            
Insulin                
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]                
Loss on purchase commitments         $ 79,300,000 82,800,000    
Loss on purchase commitments, number of new contracts recognized | Contract         0      
Maximum | AFREZZA product sales                
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]                
Sales return right following product expiration in months         12 months      
Minimum | AFREZZA product sales                
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]                
Sales return right following product expiration in months         6 months      
MidCap Credit Facility                
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]                
Principal amount [1]         $ 40,000,000.0 $ 40,000,000.0    
Principal amount             $ 100,000,000.0  
Amount outstanding         40,000,000.0      
Principal prepayment against outstanding term loans     $ 10,000,000.0          
Milestone Rights Liability | Deerfield Management Company Lp                
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]                
Contingent liability remain payable         $ 65,000,000.0     $ 65,000,000.0
Milestone Rights Liability | Maximum | Deerfield Management Company Lp                
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]                
Contingent liability for milestone payments               $ 90,000,000.0
[1]

In April 2021, the Company prepaid $10.0 million principal balance and amended the MidCap credit facility. The interest rate prior to the amendment was one-month LIBOR (2% floor) plus 6.75% and the maturity date was in August 2024.