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Schedule of Revenue from Collaborations and Services (Detail) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services $ 23,280 $ 15,114 $ 40,716 $ 31,349
Collaborations and services        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services 13,304 8,129 22,641 16,364
Collaborations and services | License Agreement | United Therapeutics Corporation        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services 12,163 7,978 21,163 15,956
Collaborations and services | Co-Promotion Agreement | Vertice Pharma LLC        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services 856   1,147  
Collaborations and services | Collaboration and License Agreement | Receptor CLA        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services 165 63 175 125
Collaborations and services | License and Distribution Agreement | Cipla Ltd        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services 37 35 73 72
Collaborations and services | Research Agreement | United Therapeutics Corporation        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services   $ 53   $ 211
Collaborations and services | Other        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services $ 83   $ 83