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Schedule of Revenue from Collaborations and Services (Detail) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2020
Jun. 30, 2019
Jun. 30, 2020
Jun. 30, 2019
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services $ 15,114 $ 15,002 $ 31,349 $ 32,450
Collaborations and services        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services 8,129 8,937 16,364 21,309
Collaborations and services | License Agreement | United Therapeutics Corporation        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services 7,978 7,779 15,956 15,394
Collaborations and services | Research Agreement | United Therapeutics Corporation        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services 53 1,058 211 5,716
Collaborations and services | Collaboration and License Agreement | Receptor CLA        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services 63 63 125 125
Collaborations and services | Distribution Agreement | Cipla Distribution Agreement        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Total revenue from collaborations and services $ 35 $ 37 $ 72 $ 74