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Fair Value of Financial Instruments - Additional Information (Detail)
9 Months Ended
Sep. 30, 2018
USD ($)
Dec. 31, 2017
USD ($)
Fair Value of Financial Instruments [Line Items]    
Restricted cash $ 527,000 $ 4,409,000
Fair value of note payable to related party, description The fair value measurement of the note payable is sensitive to the change in yield. If the yield changes by approximately 1%, from 10% to 11%, the fair value of the note payable with the conversion feature would change from $83.6 million to $82.1 million, or $1.5 million and -1.8%. Similarly, if the yield changes by approximately 3% from 10% to 13%, the fair value of the note payable with the conversion feature would change from $83.6 million to $79.3 million, or $4.3 million and -5.1%. If the yield changes by approximately 4% from 10% to 14%, the fair value of the note payable with the conversion feature would change from $83.6 million to $78.0 million, or $5.6 million and -6.7%.  
Fair value of the liability, percentage decrease 7.00%  
Minimum    
Fair Value of Financial Instruments [Line Items]    
Probabilities of meeting the milestones, amount $ 50,000,000  
Probabilities of meeting the milestones, percentage decrease 5.00%  
Fair value of the liability, percentage decrease 13.00%  
Maximum    
Fair Value of Financial Instruments [Line Items]    
Probabilities of meeting the milestones, amount $ 200,000,000  
Probabilities of meeting the milestones, percentage decrease 10.00%  
Fair value of the liability, percentage decrease 25.00%  
Note Payable Yield Changes 1    
Fair Value of Financial Instruments [Line Items]    
Note payable, percentage of interest rate change 1.00%  
Change in fair value of note payable value due to change in interest rate percentage $ 1,500,000  
Change in fair value of note payable percentage due to change in interest rate percentage (1.80%)  
Note payable, percentage of yield 0.11 0.10
Note payable to related party, fair value $ 82,100,000 $ 83,600,000
Note Payable Yield Changes 2    
Fair Value of Financial Instruments [Line Items]    
Note payable, percentage of interest rate change 3.00%  
Change in fair value of note payable value due to change in interest rate percentage $ 4,300,000  
Change in fair value of note payable percentage due to change in interest rate percentage (5.10%)  
Note payable, percentage of yield 0.13 0.10
Note payable to related party, fair value $ 79,300,000 $ 83,600,000
Note Payable Yield Changes 3    
Fair Value of Financial Instruments [Line Items]    
Note payable, percentage of interest rate change 4.00%  
Change in fair value of note payable value due to change in interest rate percentage $ 5,600,000  
Change in fair value of note payable percentage due to change in interest rate percentage (6.70%)  
Note payable, percentage of yield 0.14 0.10
Note payable to related party, fair value $ 78,000,000 $ 83,600,000
Money Market Funds    
Fair Value of Financial Instruments [Line Items]    
Cash equivalents 10,400,000 48,400,000
Restricted cash $ 500,000 $ 4,400,000