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Fair Value of Financial Instruments - Additional Information (Detail) - USD ($)
$ in Millions
6 Months Ended
Jun. 30, 2017
Dec. 31, 2016
May 12, 2016
Fair Value of Financial Instruments [Line Items]      
Cash equivalents, money market funds $ 42.1 $ 20.5  
Warrants issued, fair value     $ 12.8
Fair value of the liability, percentage decrease 7.00%    
Minimum      
Fair Value of Financial Instruments [Line Items]      
Probabilities of meeting the milestones, percentage decrease 5.00%    
Fair value of the liability, percentage decrease 14.00%    
Maximum      
Fair Value of Financial Instruments [Line Items]      
Probabilities of meeting the milestones, percentage decrease 10.00%    
Fair value of the liability, percentage decrease 26.00%    
Milestone Rights Liability | Deerfield      
Fair Value of Financial Instruments [Line Items]      
Long term liability $ 8.9    
Milestone Rights Liability | Senior convertible notes due December 31, 2019 | Deerfield      
Fair Value of Financial Instruments [Line Items]      
Long term liability 7.2 8.9  
Warrant Liability      
Fair Value of Financial Instruments [Line Items]      
Fair value of warrants liability $ 0.6 $ 7.4  
Valuation technique Monte Carlo valuation pricing model    
Fair value assumption, risk-free rate 1.40%    
Warrant liability fair value assumptions, dividend yield 0.00%    
Warrant liability fair value assumptions, remaining term 10 months 25 days    
Fair value assumption, stock price volatility 112.00%    
Fair Value, Inputs, Level 3 | Milestone Rights Liability      
Fair Value of Financial Instruments [Line Items]      
Fair value of warrants liability $ 18.2    
Fair Value, Inputs, Level 3 | Market Approach Valuation Technique | 5.75% Senior convertible notes due August 15, 2018 | Senior Convertible Notes      
Fair Value of Financial Instruments [Line Items]      
Fair value assumption, risk-free rate 20.00%    
Fair value assumption, stock price volatility 100.00%    
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Senior convertible notes due December 31, 2019      
Fair Value of Financial Instruments [Line Items]      
Market discount rate 0.12%    
Fair Value, Inputs, Level 3 | Income Approach Valuation Technique | Milestone Rights Liability      
Fair Value of Financial Instruments [Line Items]      
Market discount rate 0.00%