Exhibit 99.1

Company Contact:

Rose Alinaya

SVP, Finance

661-775-5300

ralinaya@mannkindcorp.com

MannKind Corporation Reports 2016 Fourth Quarter and Full Year Financial Results

Conference Call to Begin Today at 5:00 PM ET

VALENCIA, Calif., March 16, 2017 (GLOBE NEWSWIRE) — MannKind Corporation (NASDAQ:MNKD) (TASE:MNKD) today reported financial results for the fourth quarter and full year ended December 31, 2016. Key results include:

• Total revenue for the quarter of $12.4 million, including $10.2 million from insulin sales to Sanofi, and net income for the fourth quarter of $54.0 million including $72.0 million from the extinguishment of debt owed to Sanofi

• Total revenue for 2016 of $174.8 million, including $172.0 million in revenue previously deferred from the collaboration with Sanofi, and net income for 2016 of $125.7 million, compared with a net loss of $368.4 million for 2015

• Finished 2016 with $22.9 million of cash and cash equivalents, not including $30.6 million subsequently received from Sanofi and $16.7 million subsequently received from sale of surplus building

Fourth Quarter Results

For the fourth quarter of 2016, total net revenue of $12.4 million was comprised primarily of $10.2 million from the sale of bulk insulin to Sanofi under the terms of the settlement agreement, in addition to $1.3 million of recognized Afrezza product sales as dispensed to patients. As of December 31, 2016, deferred net revenue included $1.7 million of Afrezza product shipped to the third-party logistics provider and wholesale distributors, but not yet recognized as revenue.

Research and development expenses were $1.6 million for the fourth quarter of 2016 compared to $6.2 million in the fourth quarter of 2015, a decrease of 74.2%, primarily due to $1.9 million in decreased collaboration development work and $1.6 million in decreased consulting support for research and development projects.

Selling, general and administrative expenses were $15.3 million for the fourth quarter of 2016 compared to $8.3 million for the same quarter of 2015, an increase of 84.3%, primarily due to $8.8 million in sales and marketing expense associated with the commercialization of Afrezza, offset by a $1.8 million decrease in general and administrative costs, mainly due to the effects of the 2015 and 2016 reductions in force.

Full Year 2016 Results

Total net revenue for 2016 of $174.8 million is comprised primarily of $172.0 million net revenue previously deferred from the collaboration with Sanofi. Net revenue from commercial product sales by the Company was $1.9 million, after giving effect to gross to net adjustments on gross revenue of $2.7 million of Afrezza product dispensed to patients. Commercial product sales commenced in August 2016, after Afrezza transitioned from Sanofi to MannKind. During 2015, there was no recognition of revenue or cost of revenue related to the collaboration.

Research and development costs for 2016 were $14.9 million compared to $29.7 million for 2015, a decrease of 49.8%, primarily due to $6.2 million of reduced expenses associated with the reductions in force, $3.3 million of decreased facility spending, $3.1 million in lower project costs, and $2.1 million of reduced clinical trial costs. These decreases were partially offset by the FDA filing fee of $1.0 million for the supplemental new drug application submitted in 2016.

Selling, general and administrative expenses for 2016 were $46.9 million compared to $41.0 million for 2015, an increase of 14.4%, primarily due to increased costs for the sales and marketing of Afrezza, offset by decreased general and administrative expenses. Sales and marketing expenses were $19.8 million for 2016 compared to $1.6 million for 2015. General and administrative expenses for 2016 were $27.1 million compared to $39.4 million in 2015, a decrease of 31.2%, primarily due to decreased costs associated with the effects of the reductions in force of $9.0 million, $1.7 million in decreased professional fees and $1.7 million in reduced facility spending.

The $72.0 million gain from extinguishment of debt in 2016 resulted from the forgiveness of the full outstanding loan balance of the Sanofi Loan Facility as part of the settlement agreement with Sanofi.

Net income for 2016 was $125.7 million, or $1.37 net income per share, compared to the net loss of $368.4 million, or $4.54 net loss per share in 2015.

On March 1, 2017, following stockholder approval of the Reverse Split Proposal, the Company’s board of directors approved a reverse stock split of the Company’s common stock at a ratio of 1-for-5. On March 1, 2017, the Company filed with the Secretary of State of the State of Delaware a Certificate of Amendment of its Amended and Restated Certificate to (i) implement a one-for-five reverse stock split of the Company’s outstanding common stock and (ii) reduce the authorized number of shares of the Company’s common stock from 700 million to 140 million shares. As a result, all common stock share amounts included in this release were retroactively reduced by a factor of five and all common stock per share amounts were increased by a factor of five.

Cash and cash equivalents at December 31, 2016 were $22.9 million, compared to $35.5 million at the end of the third quarter of 2016. During the fourth quarter of 2016, cash receipts were $10.2 million from the sale of insulin to Sanofi, $4.8 million from shipments of Afrezza, $2.2 million from sales of insulin to a third party and $1.1 million from the collaboration with Receptor. Currently, $30.1 million remains available to borrow under the amended loan arrangement with The Mann Group.

Conference Call

MannKind will host a conference call and presentation webcast to discuss these results today at 5:00 p.m. Eastern Time. To view and listen to the earnings call webcast, visit MannKind’s website at http://www.mannkindcorp.com and click on the “Q4 2016 MannKind Earnings Conference Call” link in the Webcast section of News & Events. To participate in the live call by telephone, please dial (888) 771-4371 or (847) 585-4405 and use the participant passcode: 44096370.

A telephone replay will be accessible for approximately 14 days following completion of the call by dialing (888) 843-7419 or (630) 652-3042 and use the participant passcode: 4409 6370#. A replay will also be available on MannKind’s website for 14 days.

About MannKind Corporation

MannKind Corporation (NASDAQ and TASE: MNKD) focuses on the discovery, development and commercialization of therapeutic products for patients with diseases such as diabetes. MannKind maintains a website at http://www.mannkindcorp.com to which MannKind regularly posts copies of its press releases as well as additional information about MannKind. Interested persons can subscribe on the MannKind website to e-mail alerts that are sent automatically when MannKind issues press releases, files its reports with the Securities and Exchange Commission or posts certain other information to the website.

Forward-Looking Statements

This press release contains forward-looking statements that involve risks and uncertainties, including statements regarding MannKind’s ability to directly commercialize pharmaceutical products. Words such as “believes”, “anticipates”, “plans”, “expects”, “intend”, “will”, “goal”, “potential” and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based upon the MannKind’s current expectations. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, the ability to generate significant product sales for MannKind, MannKind’s ability to manage its existing cash resources or raise additional cash resources, stock price volatility and other risks detailed in MannKind’s filings with the Securities and Exchange Commission, including the

Annual Report on Form 10-K for the year ended December 31, 2016 and subsequent periodic reports on Form 10-Q and current reports on Form 8-K. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. All forward-looking statements are qualified in their entirety by this cautionary statement, and MannKind undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date of this press release.

MannKind Corporation

Condensed Consolidated Statements of Operations

(Unaudited)

(In thousands, except per share amounts)

	Three months ended December 31,						Twelve months ended December 31,
	2016			2015			2016			2015
Revenue:
Net revenue – collaboration	$	10,184		$	—		$	171,965		$	—
Net revenue – commercial product sales		1,322			—			1,895			—
Revenue – bulk insulin sales		898			—			898			—
Total net revenue		12,404			—			174,758			—
Expenses:
Cost of revenue — collaboration		10,230			—			32,971			—
Cost of goods sold		1,553			49,057			17,121			64,745
Research and development		1,559			6,218			14,917			29,674
Selling, general and administrative		15,333			8,311			46,928			40,960
Property and equipment impairment		1,259			140,412			1,259			140,412
(Gain) loss on foreign currency translation		(3,433	)		2,697			(3,433	)		2,697
(Gain) loss on purchase commitments		(2,265	)		66,167			(2,265	)		66,167
Total expenses		24,236			272,862			107,498			344,655
Income (loss) from operations		(11,832	)		(272,862	)		67,260			(344,655	)
Other income (expense):
Change in fair value of warrant liability		(2,510	)		—			5,369			—
Interest income		15			10			85			18
Interest expense on notes		(3,010	)		(3,331	)		(15,576	)		(21,231	)
Interest expense on note payable to principal stockholder		(729	)		(729	)		(2,901	)		(2,894	)
Gain (loss) on extinguishment of debt		72,024			—			72,024			(1,049	)
Other income (expense)		18			(106	)		(597	)		1,366
Net income (loss)	$	53,976		$	(277,018	)	$	125,664		$	(368,445	)
Net income (loss) per share — basic	$	0.56		$	(3.30	)	$	1.37		$	(4.54	)
Net income (loss) per share — diluted	$	0.56		$	(3.30	)	$	1.36		$	(4.54	)
Shares used to compute basic net income (loss) per share		95,676			83,862			92,053			81,233
Shares used to compute diluted net income (loss) per share		96,510			83,862			92,085			81,233

MannKind Corporation

Condensed Consolidated Balance Sheets

(Unaudited)

(In thousands)

	December 31, 2016			December 31, 2015
Assets
Current assets:
Cash and cash equivalents	$	22,895		$	59,074
Accounts receivable		302			—
Receivable from Sanofi		30,557			23
Inventory		2,331			—
Asset held for sale		16,730			—
Deferred costs from commercial product sales		309			—
Deferred costs from collaboration		—			13,539
Prepaid expenses and other current assets		4,364			4,018
Total current assets		77,488			76,654
Property and equipment — net		28,927			48,749
Other assets		648			1,009
Total assets	$	107,063		$	126,412
Liabilities and Stockholders’ Deficit
Current liabilities
Accounts payable	$	3,263		$	15,599
Accrued expenses and other current liabilities		7,937			7,929
Facility financing obligation		71,339			74,582
Deferred revenue — net		3,419			—
Deferred payments from collaboration		1,000			140,231
Deferred sales from collaboration		—			17,503
Recognized loss on purchase commitments — current		5,093			12,475
Total current liabilities		92,051			268,319
Note payable to principal stockholder		49,521			49,521
Accrued interest — note payable to principal stockholder		9,281			6,380
Senior convertible notes		27,635			27,613
Sanofi loan facility and loss share obligation		—			62,371
Recognized loss on purchase commitments — long term		95,942			53,692
Warrant liability		7,381			—
Milestone rights liability and other liabilities		8,845			8,845
Total liabilities		290,656			476,741
Total stockholders’ deficit		(183,593	)		(350,329	)
Total liabilities and stockholders’ deficit	$	107,063		$	126,412

***