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Description of Business and Basis of Presentation - Additional Information (Detail) (USD $)
1 Months Ended 6 Months Ended 268 Months Ended 1 Months Ended 6 Months Ended 1 Months Ended 6 Months Ended
Oct. 31, 2012
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2013
Dec. 31, 2012
May 17, 2012
Mar. 31, 2012
Feb. 28, 2012
Dec. 31, 2011
May 17, 2012
Other Than Equity
Mar. 31, 2012
Other Than Equity
Jun. 30, 2013
Maximum
Mar. 18, 2013
Maximum
At Market Sales Agreement
Jun. 30, 2013
Mann Group
Oct. 31, 2012
Mann Group
May 17, 2012
Mann Group
Forward Purchase Contracts
Mar. 31, 2012
Mann Group
Forward Purchase Contracts
Jun. 30, 2013
Mann Group
Forward Purchase Contracts
Equity Component
May 17, 2012
Mann Group
Forward Purchase Contracts
Other Than Equity
Mar. 31, 2012
Mann Group
Forward Purchase Contracts
Other Than Equity
Jun. 30, 2013
Senior convertible notes due December 15, 2013
Dec. 31, 2012
Senior convertible notes due December 15, 2013
Dec. 12, 2006
Senior convertible notes due December 15, 2013
Jul. 01, 2013
Notes 9.75% Due in 2019
First Tranche
Subsequent Event
Jul. 01, 2013
Senior Notes Additional
First Tranche
Subsequent Event
Jun. 30, 2013
Money market funds
Dec. 31, 2012
Money market funds
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]                                                      
Deficit accumulated during the development stage   $ 2,192,001,000   $ 2,192,001,000 $ 2,104,912,000                                            
Goodwill impairment       151,428,000                                              
Negative cash flow from operation since inception   61,771,000 57,504,000 1,658,032,000                                              
Principal amount of convertible senior notes                                         115,000,000 115,000,000 115,000,000        
Promissory note maturity date   Jan. 01, 2014                                     Dec. 15, 2013            
Senior notes, effective interest rate                                         3.75%   3.75% 9.75%      
Cash and cash equivalents   28,529,000 31,639,000 28,529,000 61,840,000       2,681,000                                    
Available borrowings under loan agreement   125,400,000   125,400,000                                              
Available borrowings date                       Sep. 30, 2013                              
Warrants, expiration date 2013-10 2013-10   2013-10                                              
Net proceeds from public offering 86,300,000                                                    
Gross proceeds from public offering   89,700,000                                                  
Proceeds from exercise warrants   25,100,000                                                  
Warrants remained unexercised   64,600,000   64,600,000                   64,600,000                          
Restricted Stock Agreed to be Purchased by Lender               77,200,000           78,000,000 107,400,000                        
Aggregate offering price of common stock under agreement                         50,000,000                            
Senior secured notes                                               40,000,000 120,000,000    
Senior notes, Maturity Year                                               2019      
Maturity period of cash equivalents   90 days or less at the time of purchase                                                  
Cash and cash equivalents   28,500,000   28,500,000 61,800,000                                         25,900,000 60,800,000
Capital stock authorized   300,869,683 31,250,000 300,869,683 286,035,082     31,250,000           31,250,000                          
Number of Shares that recorded the portion of the derivative instrument representing equity                                   14,700,000                  
Number of Shares that recorded the portion of the derivative instrument representing outside of equity                           16,500,000                          
Change in fair value recognized in other income     $ 12,000,000       $ (336,000)                                        
Risk Free Interest Rate                   0.18% 0.06%               0.08% 0.08%              
Discount for lack of marketability           1.67% 1.64%                 10.27% 2.57%                    
Valuation date stock price                   $ 1.69                 $ 2.40