Description of Business and Basis of Presentation - Additional Information (Detail) (USD $)
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1 Months Ended | 6 Months Ended | 268 Months Ended | 1 Months Ended | 6 Months Ended | 1 Months Ended | 6 Months Ended | ||||||||||||||||||||
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Oct. 31, 2012
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Jun. 30, 2013
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Jun. 30, 2012
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Jun. 30, 2013
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Dec. 31, 2012
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May 17, 2012
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Mar. 31, 2012
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Feb. 28, 2012
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Dec. 31, 2011
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May 17, 2012
Other Than Equity
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Mar. 31, 2012
Other Than Equity
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Jun. 30, 2013
Maximum
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Mar. 18, 2013
Maximum
At Market Sales Agreement
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Jun. 30, 2013
Mann Group
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Oct. 31, 2012
Mann Group
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May 17, 2012
Mann Group
Forward Purchase Contracts
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Mar. 31, 2012
Mann Group
Forward Purchase Contracts
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Jun. 30, 2013
Mann Group
Forward Purchase Contracts
Equity Component
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May 17, 2012
Mann Group
Forward Purchase Contracts
Other Than Equity
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Mar. 31, 2012
Mann Group
Forward Purchase Contracts
Other Than Equity
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Jun. 30, 2013
Senior convertible notes due December 15, 2013
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Dec. 31, 2012
Senior convertible notes due December 15, 2013
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Dec. 12, 2006
Senior convertible notes due December 15, 2013
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Jul. 01, 2013
Notes 9.75% Due in 2019
First Tranche
Subsequent Event
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Jul. 01, 2013
Senior Notes Additional
First Tranche
Subsequent Event
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Jun. 30, 2013
Money market funds
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Dec. 31, 2012
Money market funds
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Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] | |||||||||||||||||||||||||||
Deficit accumulated during the development stage | $ 2,192,001,000 | $ 2,192,001,000 | $ 2,104,912,000 | ||||||||||||||||||||||||
Goodwill impairment | 151,428,000 | ||||||||||||||||||||||||||
Negative cash flow from operation since inception | 61,771,000 | 57,504,000 | 1,658,032,000 | ||||||||||||||||||||||||
Principal amount of convertible senior notes | 115,000,000 | 115,000,000 | 115,000,000 | ||||||||||||||||||||||||
Promissory note maturity date | Jan. 01, 2014 | Dec. 15, 2013 | |||||||||||||||||||||||||
Senior notes, effective interest rate | 3.75% | 3.75% | 9.75% | ||||||||||||||||||||||||
Cash and cash equivalents | 28,529,000 | 31,639,000 | 28,529,000 | 61,840,000 | 2,681,000 | ||||||||||||||||||||||
Available borrowings under loan agreement | 125,400,000 | 125,400,000 | |||||||||||||||||||||||||
Available borrowings date | Sep. 30, 2013 | ||||||||||||||||||||||||||
Warrants, expiration date | 2013-10 | 2013-10 | 2013-10 | ||||||||||||||||||||||||
Net proceeds from public offering | 86,300,000 | ||||||||||||||||||||||||||
Gross proceeds from public offering | 89,700,000 | ||||||||||||||||||||||||||
Proceeds from exercise warrants | 25,100,000 | ||||||||||||||||||||||||||
Warrants remained unexercised | 64,600,000 | 64,600,000 | 64,600,000 | ||||||||||||||||||||||||
Restricted Stock Agreed to be Purchased by Lender | 77,200,000 | 78,000,000 | 107,400,000 | ||||||||||||||||||||||||
Aggregate offering price of common stock under agreement | 50,000,000 | ||||||||||||||||||||||||||
Senior secured notes | 40,000,000 | 120,000,000 | |||||||||||||||||||||||||
Senior notes, Maturity Year | 2019 | ||||||||||||||||||||||||||
Maturity period of cash equivalents | 90 days or less at the time of purchase | ||||||||||||||||||||||||||
Cash and cash equivalents | 28,500,000 | 28,500,000 | 61,800,000 | 25,900,000 | 60,800,000 | ||||||||||||||||||||||
Capital stock authorized | 300,869,683 | 31,250,000 | 300,869,683 | 286,035,082 | 31,250,000 | 31,250,000 | |||||||||||||||||||||
Number of Shares that recorded the portion of the derivative instrument representing equity | 14,700,000 | ||||||||||||||||||||||||||
Number of Shares that recorded the portion of the derivative instrument representing outside of equity | 16,500,000 | ||||||||||||||||||||||||||
Change in fair value recognized in other income | $ 12,000,000 | $ (336,000) | |||||||||||||||||||||||||
Risk Free Interest Rate | 0.18% | 0.06% | 0.08% | 0.08% | |||||||||||||||||||||||
Discount for lack of marketability | 1.67% | 1.64% | 10.27% | 2.57% | |||||||||||||||||||||||
Valuation date stock price | $ 1.69 | $ 2.40 |