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Fair Value of Financial Instruments - Fair Value of Financial Instruments (Detail) - USD ($)
$ in Thousands
Mar. 31, 2023
Dec. 31, 2022
Carrying Amount | MidCap Credit Facility    
Financial liabilities:    
Total financial liabilities fair value $ 39,371 $ 39,371
Carrying Amount | Senior Convertible Notes    
Financial liabilities:    
Total financial liabilities fair value 225,761 225,761
Carrying Amount | Mann Group Convertible Note    
Financial liabilities:    
Total financial liabilities fair value 8,829 8,829
Carrying Amount | Milestone Rights Liability    
Financial liabilities:    
Total financial liabilities fair value 4,838 4,838
Carrying Amount | Contingent Milestone Liability    
Financial liabilities:    
Total financial liabilities fair value 610 610
Carrying Amount | Financing Liability    
Financial liabilities:    
Total financial liabilities fair value 104,067 104,077
Estimate of Fair Value Measurement | Fair Value, Inputs, Level 3 | MidCap Credit Facility    
Financial liabilities:    
Total financial liabilities fair value 41,394 41,070
Estimate of Fair Value Measurement | Senior Convertible Notes | Fair Value, Inputs, Level 3    
Financial liabilities:    
Total financial liabilities fair value 239,283 253,864
Estimate of Fair Value Measurement | Mann Group Convertible Note | Fair Value, Inputs, Level 3    
Financial liabilities:    
Total financial liabilities fair value 16,354 20,836
Estimate of Fair Value Measurement | Milestone Rights Liability | Fair Value, Inputs, Level 3    
Financial liabilities:    
Total financial liabilities fair value 12,700 12,600
Estimate of Fair Value Measurement | Contingent Milestone Liability | Fair Value, Inputs, Level 3    
Financial liabilities:    
Total financial liabilities fair value 1,010 960
Estimate of Fair Value Measurement | Financing Liability | Fair Value, Inputs, Level 3    
Financial liabilities:    
Total financial liabilities fair value $ 103,221 $ 103,239