EXHIBIT 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Hollis-Eden Pharmaceuticals, Inc.

San Diego, California

We hereby consent to the incorporation by reference in the Prospectus constituting a part of the Registration Statement on Form S-3 of our reports dated March 31, 2009, relating to the financial statements of Hollis-Eden Pharmaceuticals, Inc. and schedules of Hollis-Eden Pharmaceuticals, Inc.’s appearing in the Company’s Annual Report on Form 10-K for the year ended December 31, 2008.

We also consent to the reference to us under the caption “Experts” in the Prospectus.

/s/    BDO Seidman, LLP         

BDO Seidman, LLP

San Diego, CA

January 6, 2010