Exhibit 32.2

CERTIFICATION OF CHIEF FINANCIAL OFFICER

IN ACCORDANCE WITH SECTION 906 OF THE SARBANES-OXLEY ACT

In connection with the quarterly report of Sharps Compliance Corp. (the “Company”) on Form 10-Q for the three  months ended September 30, 2009, as filed with the Securities and Exchange Commission on the date hereof, I, David P. Tusa, Executive Vice President, Chief Financial Officer, Business Development and Corporate Secretary of the Company, certify, pursuant to 18 U.S.C. §1350, as adopted pursuant to §906 of the Sarbanes-Oxley Act of 2002, to the best of my knowledge that:

(1)   The Form 10-Q report for the three months ended September 30, 2009, filed with the Securities and Exchange Commission on October 30, 2009 fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2)   The information contained in the Form 10-Q report for the three months ended September 30, 2009 fairly presents, in all material respects, the financial condition and results of operations of Sharps Compliance Corp.

By: /s/ DAVID P. TUSA                                                                                                             Date: October 30, 2009

David P. Tusa

Executive Vice President

Chief Financial Officer,

Business Development and

Corporate Secretary