Exhibit 32.1

CERTIFICATION OF CHIEF EXECUTIVE OFFICER

IN ACCORDANCE WITH SECTION 906 OF THE SARBANES-OXLEY ACT

In connection with the quarterly report of Sharps Compliance Corp. (the “Company”) on Form 10-Q for the three and nine months ended March 31, 2009, as filed with the Securities and Exchange Commission on the date hereof, I, Dr. Burton J. Kunik, Chairman of the Board, Chief Executive Officer and President of the Company, certify, pursuant to 18 U.S.C. §1350, as adopted pursuant to §906 of the Sarbanes-Oxley Act of 2002, to the best of my knowledge that:

(1)   The Form 10-Q report for the three and nine months ended March 31, 2009, filed with the Securities and Exchange Commission on May 14, 2009, fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2)   The information contained in the Form 10-Q report for the three and nine months ended March 31, 2009 fairly presents, in all material respects, the financial condition and results of operations of Sharps Compliance Corp.

By:  /s/ DR. BURTON J. KUNIK	Date: May 14, 2009
Dr. Burton J. Kunik
Chairman of the Board of Directors,
and Chief Executive Officer