Anika 13G

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No. 6 )*

ANIKA THERAPEUTICS, INC.

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

035255108

(CUSIP Number)

October 31, 2006

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

X Rule 13d-1(b)

____ Rule 13d-1(c)

____ Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

SEC 1745 (1-06)

Page 1 of 15 pages

CUSIP No. 035255108
____________________________________________________________________________

Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Federated Investors, Inc.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

(b)

SEC Use Only

Citizenship or Place of Organization: Pennsylvania

Number of

Sole Voting Power 490,300

Shares Bene-

ficially

Shared Voting Power

Owned by Each

Reporting

Sole Dispositive Power 490,300
Person With:

Shared Dispositive Power

Aggregate Amount Beneficially Owned by Each Reporting Person 490,300

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)

11.

Percent of Class Represented by Amount in Row (9) 4.61%

12.

Type of Reporting Person (See Instructions) HC

Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Voting Shares Irrevocable Trust

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

(b)

SEC Use Only

Citizenship or Place of Organization: Pennsylvania

Number of

Sole Voting Power 490,300

Shares Bene-

ficially

Shared Voting Power

Owned by Each

Reporting

Sole Dispositive Power 490,300
Person With:

Shared Dispositive Power

Aggregate Amount Beneficially Owned by Each Reporting Person 490,300

Page 2 of 15 pages

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)

11.

Percent of Class Represented by Amount in Row (9) 4.61%

12.

Type of Reporting Person (See Instructions) OO

Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

John F. Donahue

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

(b)

SEC Use Only

Citizenship or Place of Organization: United States

Number of

Sole Voting Power

Shares Bene-

ficially

Shared Voting Power 490,300

Owned by Each

Reporting

Sole Dispositive Power
Person With:

Shared Dispositive Power 490,300

Aggregate Amount Beneficially Owned by Each Reporting Person 490,300

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)

11.

Percent of Class Represented by Amount in Row (9) 4.61%

12.

Type of Reporting Person (See Instructions) IN

Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Rhodora J. Donahue

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

(b)

SEC Use Only

Citizenship or Place of Organization: United States

Number of

Sole Voting Power

Shares Bene-

ficially

Shared Voting Power 490,300

Owned by Each

Reporting

Sole Dispositive Power
Person With:

Shared Dispositive Power 490,300

Aggregate Amount Beneficially Owned by Each Reporting Person 490,300

Page 3 of 15 pages

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)

11.

Percent of Class Represented by Amount in Row (9) 4.61%

12.

Type of Reporting Person (See Instructions) IN

Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

J. Christopher Donahue

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)

(b)

SEC Use Only

Citizenship or Place of Organization: United States

Number of

Sole Voting Power

Shares Bene-

ficially

Shared Voting Power 490,300

Owned by Each

Reporting

Sole Dispositive Power
Person With:

Shared Dispositive Power 490,300

Aggregate Amount Beneficially Owned by Each Reporting Person 490,300

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)

11.

Percent of Class Represented by Amount in Row (9) 4.61%

12.

Type of Reporting Person (See Instructions) IN

Page 4 of 15 pages

INSTRUCTIONS FOR SCHEDULE 13G

Instructions for Cover Page

(l)

Names and I.R.S. Identification Numbers of Reporting Persons—Furnish the full legal name of each person for whom the report is filed—i.e., each person required to sign the schedule itself—including each member of a group. Do not include the name of a person required to be identified in the report but who is not a reporting person. Reporting persons that are entities are also requested to furnish their I.R.S. identification numbers, although disclosure of such numbers is voluntary, not mandatory (see “SPECIAL INSTRUCTIONS FOR COMPLYING WITH SCHEDULE 13G” below).

(2)

If any of the shares beneficially owned by a reporting person are held as a member of a group and that membership is expressly affirmed, please check row 2(a). If the reporting person disclaims membership in a group or describes a relationship with other persons but does not affirm the existence of a group, please check row 2(b) [unless it is a joint filing pursuant to Rule 13d-1(k)(1) in which case it may not be necessary to check row 2(b)].

(3)

The third row is for SEC internal use; please leave blank.

(4)

Citizenship or Place of Organization—Furnish citizenship if the named reporting person is a natural person. Otherwise, furnish place of organization.

(5)-(9), (11) Aggregate Amount Beneficially Owned By Each Reporting Person, Etc.—Rows (5) through (9) inclusive, and (11) are to be completed in accordance with the provisions of Item 4 of Schedule 13G. All percentages are to be rounded off to the nearest tenth (one place after decimal point).

(10)

Check if the aggregate amount reported as beneficially owned in row (9) does not include shares as to which beneficial ownership is disclaimed pursuant to Rule 13d-4 (17 CFR 240.13d-4] under the Securities Exchange Act of 1934.

(12)

Type of Reporting Person—Please classify each “reporting person” according to the following breakdown (see Item 3 of Schedule 13G) and place the appropriate symbol on the form:

Category

Symbol

Broker Dealer

Bank

Insurance Company

Investment Company

Investment Adviser

Employee Benefit Plan, Pension Fund,

or Endowment Fund

Parent Holding Company/Control Person

Savings Association

Church Plan

Corporation

Partnership

Individual

Other

Notes:

Attach as many copies of the second part of the cover page as are needed, one reporting person per page.

Page 5 of 15 pages

Filing persons may, in order to avoid unnecessary duplication, answer items on the schedules (Schedule 13D, 13G or 14D-1) by appropriate cross references to an item or items on the cover page(s). This approach may only be used where the cover page item or items provide all the disclosure required by the schedule item. Moreover, such a use of a cover page item will result in the item becoming a part of the schedule and accordingly being considered as “filed” for purposes of Section 18 of the Securities Exchange Act or otherwise subject to the liabilities of that section of the Act.

Reporting persons may comply with their cover page filing requirements by filing either completed copies of the blank forms available from the Commission, printed or typed facsimiles, or computer printed facsimiles, provided the documents filed have identical formats to the forms prescribed in the Commission’s regulations and meet existing Securities Exchange Act rules as to such matters as clarity and size (Securities Exchange Act Rule 12b-12).

SPECIAL INSTRUCTIONS FOR COMPLYING WITH SCHEDULE 13G

Under Sections 13(d), 13(g), and 23 of the Securities Exchange Act of 1934 and the rules and regulations thereunder, the Commission is authorized to solicit the information required to be supplied by this schedule by certain security holders of certain issuers.

Disclosure of the information specified in this schedule is mandatory, except for I.R.S. identification numbers, disclosure of which is voluntary. The information will be used for the primary purpose of determining and disclosing the holdings of certain beneficial owners of certain equity securities. This statement will be made a matter of public record. Therefore, any information given will be available for inspection by any member of the public.

Because of the public nature of the information, the Commission can use it for a variety of purposes, including referral to other governmental authorities or securities self-regulatory organizations for investigatory purposes or in connection with litigation involving the Federal securities laws or other civil, criminal or regulatory statutes or provisions. I.R.S. identification numbers, if furnished, will assist the Commission in identifying security holders and, therefore, in promptly processing statements of beneficial ownership of securities.

Failure to disclose the information requested by this schedule, except for I.R.S. identification numbers, may result in civil or criminal action against the persons involved for violation of the Federal securities laws and rules promulgated thereunder.

GENERAL INSTRUCTIONS

Statements filed pursuant to Rule 13d-1(b) containing the information required by this schedule shall be filed not later than February 14 following the calendar year covered by the statement or within the time specified in Rules 13d-1(b)(2) and 13d-2(c). Statements filed pursuant to Rule 13d-1(c) shall be filed within the time specified in Rules 13d-1(c), 13d-2(b) and 13d-2(d). Statements filed pursuant to Rule 13d-1(d) shall be filed not later than February 14 following the calendar year covered by the statement pursuant to Rules 13d-1(d) and 13d-2(b).

Information contained in a form which is required to be filed by rules under section 13(f) (15 U.S.C. 78m(f)) for the same calendar year as that covered by a statement on this schedule may be incorporated by reference in response to any of the items of this schedule. If such information is incorporated by reference in this schedule, copies of the relevant pages of such form shall be filed as an exhibit to this schedule.

The item numbers and captions of the items shall be included but the text of the items is to be omitted. The answers to the items shall be so prepared as to indicate clearly the coverage of the items without referring to the text of the items. Answer every item. If an item is inapplicable or the answer is in the negative, so state.

Item 1.

Page 6 of 15 pages

(a)

Name of Issuer

ANIKA THERAPEUTICS, INC.

(b)

Address of Issuer’s Principal Executive Offices

160 New Boston Street

Woburn, MA 01801

Item 2.

(a)

Name of Person Filing

(b)

Address of Principal Business Office or, if none, Residence

Federated Investors Tower, Pittsburgh, PA 15222-3779

(c)

Citizenship

(d)

Title of Class of Securities

Common Stock

(e)

CUSIP Number

035255108

Item 3. If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a)

____

Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).

(b)

____

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

(c)

____

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).

(d)

____

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8).

(e)

____

An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);

(f)

____

An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);

(g)

__X__

A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);

(h)

____

A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i)

____

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j)

____

Group, in accordance with §240.13d-1(b)(1)(ii)(J).

Item 4. Ownership.

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

A. Federated Investors, Inc. (See Footnote 1, next page)

(a)

Amount beneficially owned: 490,300

(b)

Percent of class: 4.61%

(c)

Number of shares as to which the person has:

Page 7 of 15 pages

(i)

Sole power to vote or to direct the vote 490,300

(ii)

Shared power to vote or to direct the vote -0-

(iii)

Sole power to dispose or to direct the disposition of 490,300

(iv)

Shared power to dispose or to direct the disposition of -0-

B. Voting Shares Irrevocable Trust

(a)

Amount beneficially owned: 490,300

(b)

Percent of class: 4.61%

(c)

Number of shares as to which the person has:

(i)

Sole power to vote or to direct the vote 490,300

(ii)

Shared power to vote or to direct the vote -0-

(iii)

Sole power to dispose or to direct the disposition of 490,300

(iv)

Shared power to dispose or to direct the disposition of -0-

C. John F. Donahue

(a)

Amount beneficially owned: 490,300

(b)

Percent of class: 4.61%

(c)

Number of shares as to which the person has:

(i)

Sole power to vote or to direct the vote -0-

(ii)

Shared power to vote or to direct the vote 490,300

(iii)

Sole power to dispose or to direct the disposition of -0-

(iv)

Shared power to dispose or to direct the disposition of 490,300

D. Rhodora J. Donahue

(a)

Amount beneficially owned: 490,300

(b)

Percent of class: 4.61%

(c)

Number of shares as to which the person has:

(i)

Sole power to vote or to direct the vote -0-

(ii)

Shared power to vote or to direct the vote 490,300

(iii)

Sole power to dispose or to direct the disposition of -0-

(iv)

Shared power to dispose or to direct the disposition of 490,300

E. J. Christopher Donahue

(a)

Amount beneficially owned: 490,300

(b)

Percent of class: 4.61%

(c)

Number of shares as to which the person has:

(i)

Sole power to vote or to direct the vote -0-

(ii)

Shared power to vote or to direct the vote 490,300

(iii)

Sole power to dispose or to direct the disposition of -0-

(iv)

Shared power to dispose or to direct the disposition of 490,300

Page 8 of 15 pages

Instruction. For computations regarding securities which represent a right to acquire an underlying security see §240.13d-3(d)(1).

Item 5. Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following _X_.

Instruction: Dissolution of a group requires a response to this item.

Item 6. Ownership of More than Five Percent on Behalf of Another Person. NOT APPLICABLE

Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company See Exhibit “1” Attached

Item 8. Identification and Classification of Members of the Group NOT APPLICABLE

Item 9. Notice of Dissolution of Group NOT APPLICABLE

Item 10. Certification

(a)

The following certification shall be included if the statement is filed pursuant to §240.13d-1(b):

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

(b)

The following certification shall be included if the statement is filed pursuant to §240.13d-1(c):

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: November 9, 2006

By: /s/J. Christopher Donahue

Name/Title: J. Christopher Donahue, as President of Federated Investors, Inc.

Date: November 9, 2006

By: /s/John F. Donahue, individually and as Trustee of Voting Shares Irrevocable Trust, by

J. Christopher Donahue, as attorney-in-fact

Date: November 9, 2006

By: /s/Rhodora J. Donahue, individually and as Trustee of Voting Shares Irrevocable Trust, by

J. Christopher Donahue, as attorney-in-fact

Date: November 9, 2006

Page 9 of 15 pages

By: /s/J. Christopher Donahue

Name/Title: J. Christopher Donahue, individually and as Trustee of Voting Shares Irrevocable Trust

The original statement shall be signed by each person on whose behalf the statement is filed or his authorized representative. If the statement is signed on behalf of a person by his authorized representative other than an executive officer or general partner of the filing person, evidence of the representative’s authority to sign on behalf of such person shall be filed with the statement, provided, however, that a power of attorney for this purpose which is already on file with the Commission may be incorporated by reference. The name and any title of each person who signs the statement shall be typed or printed beneath his signature.

NOTE: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See §240.13d-7 for other parties for whom copies are to be sent.

Attention: Intentional misstatements or omissions of fact constitute Federal criminal violations (See 18 U.S.C. 1001)

Page 10 of 15 pages

EXHIBIT “1”

ITEM 3 CLASSIFICATION OF

REPORTING PERSONS

Identity and Classification of Each Reporting Person

IDENTITY

CLASSIFICATION UNDER ITEM 3

Federated Equity Funds

(d) Investment company registered under

section 8 of the Investment Company Act

of 1940 (15 U.S.C. 80a-8).

Federated Insurance Series

(d) Investment company registered under

section 8 of the Investment Company Act

of 1940 (15 U.S.C. 80a-8).

Federated Equity Management Company

(e) Investment Adviser registered under

of Pennsylvania

section 203 of the Investment Advisers

Act of 1940

Federated Global Investment

(e) Investment Adviser registered under

Management Corp.

section 203 of the Investment Advisers

Act of 1940

Federated Investors, Inc.