Note 12 - Equity Incentive Plan - Stock Options (Details) $ / shares in Units, $ in Thousands	9 Months Ended
	Sep. 30, 2022 USD ($) $ / shares shares
Outstanding, shares (in shares) | shares	1,175,993
Outstanding, Weighted Average Exercise (in dollars per share) | $ / shares	$ 39.56
Granted, shares (in shares) | shares	486,901
Granted, Weighted Average Exercise Price (in dollars per share) | $ / shares	$ 27.60
Exercised, shares (in shares) | shares	(437)
Exercised, Weighted Average Exercise Price (in dollars per share) | $ / shares	$ 9.10
Exercised, Aggregate Intrinsic Value | $	$ 10
Forfeited and canceled, shares (in shares) | shares	(156,672)
Forfeited and canceled, Weighted Average Exercise Price (in dollars per share) | $ / shares	$ 44.08
Outstanding, shares (in shares) | shares	1,505,785
Outstanding, Weighted Average Exercise Price (in dollars per share) | $ / shares	$ 35.21
Outstanding, Weighted Average Remaining Contractual Term (Year)	8 years 3 months 18 days
Outstanding, Aggregate Intrinsic Value | $	$ 78
Vested, shares (in shares) | shares	499,617
Vested, Weighted Average Exercise Price (in dollars per share) | $ / shares	$ 40.00
Vested, Weighted Average Remaining Contractual Term (Year)	7 years 3 months 18 days
Vested, Aggregate Intrinsic Value | $	$ 8
Vested and expected to vest, shares (in shares) | shares	1,505,785
Vested and expected to vest, Weighted Average Exercise Price (in dollars per share) | $ / shares	$ 35.21
Vested and expected to vest, Weighted Average Remaining Contractual Term (Year)	8 years 3 months 18 days
Vested and expected to vest, Aggregate Intrinsic Value | $	$ 78