Note 13 - Revenue and Geographic Information (Tables)

12 Months Ended

Dec. 31, 2021

Notes Tables

Revenue from External Customers by Products and Services [Table Text Block]

	Years Ended December 31,
	2021		2020		2019
Product revenue	$	147,794	$	130,457	$	114,512
Licensing, milestone and contract revenue		-		-		98
Total revenue	$	147,794	$	130,457	$	114,610

	Years Ended December 31,
	2021					2020					2019
	Revenue		Percentage of Product Revenue			Revenue		Percentage of Product Revenue			Revenue		Percentage of Product Revenue
OA Pain Management	$	89,503		61	%	$	83,029		64	%	$	103,466		90	%
Joint Preservation and Restoration		48,588		33	%		39,368		30	%		2,070		2	%
Non-Orthopedic		9,703		6	%		8,060		6	%		8,976		8	%
Total	$	147,794		100	%	$	130,457		100	%	$	114,512		100	%

Schedule of Revenue and Operating Income by Geographical Areas [Table Text Block]

	Years Ended December 31,
	2021					2020					2019
	Total		Percentage of			Total		Percentage of			Total		Percentage of
	Revenue		Revenue			Revenue		Revenue			Revenue		Revenue
Geographic Location:
United States	$	113,833		77	%	$	103,182		79	%	$	90,302		79	%
Europe		19,580		13	%		14,179		11	%		14,744		13	%
Other		14,381		10	%		13,096		10	%		9,564		8	%
Total	$	147,794		100	%	$	130,457		100	%	$	114,610		100	%

Schedule of Revenue from External Customers and Long-Lived Assets, by Geographical Areas [Table Text Block]

	Years Ended December 31,
	2021		2020
United States	$	46,068	$	48,611
Italy		1,534		2,002
Total	$	47,602	$	50,613