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Note 9 - Intangible Assets (Details Textual) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Dec. 31, 2018
Amortization of Intangible Assets, Total $ 200 $ 300 $ 500 $ 500  
Impairment of Intangible Assets, Finite-lived     281  
Intangible Assets, Net (Excluding Goodwill), Total 8,303   8,303   $ 9,191
HYALOSPINE Developed Technology Asset [Member]          
Impairment of Intangible Assets, Finite-lived 300        
MEROGEL INJECTIBLE Assets [Member]          
Intangible Assets, Net (Excluding Goodwill), Total $ 100   $ 100