Note 9 - Intangible Assets (Details Textual) - USD ($)	3 Months Ended
Mar. 31, 2019	Mar. 31, 2018	Dec. 31, 2018
Amortization of Intangible Assets, Total	$ 300,000
Impairment of Intangible Assets, Finite-lived	281,000
Intangible Assets, Net (Excluding Goodwill), Total	8,467,000		$ 9,191,000
HYALOSPINE Developed Technology Asset [Member]
Impairment of Intangible Assets, Finite-lived	300,000
MEROGEL INJECTIBLE Assets [Member]
Intangible Assets, Net (Excluding Goodwill), Total	$ 100,000

The aggregate expense charged against earnings to allocate the cost of intangible assets (nonphysical assets not used in production) in a systematic and rational manner to the periods expected to benefit from such assets. As a noncash expense, this element is added back to net income when calculating cash provided by or used in operations using the indirect method.

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The amount of impairment loss recognized in the period resulting from the write-down of the carrying amount of a finite-lived intangible asset to fair value.

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Sum of the carrying amounts of all intangible assets, excluding goodwill, as of the balance sheet date, net of accumulated amortization and impairment charges.

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