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Note 3 - Revenue by Product Group, by Significant Customer and by Geographic Location; Geographic Information (Tables)
 12 Months Ended
Dec. 31, 2018
Notes Tables  
Schedule of Segment Reporting Information, by Segment [Table Text Block]
    Years Ended December 31,
    2018   2017   2016
    Revenue   Percentage
of Product
Revenue		   Revenue   Percentage
of Product
Revenue		   Revenue   Percentage
of Product
Revenue
Orthobiologics   $
93,556
      
89
 %   $
93,816
      
87
 %   $
89,695
      
87
 %
Dermal    
396
      
0
 %    
2,755
      
3
 %    
2,759
      
3
 %
Surgical    
5,514
      
5
 %    
5,262
      
5
 %    
5,427
      
5
 %
Other    
6,065
      
6
 %    
5,950
      
5
 %    
5,051
      
5
 %
    $
105,531
      
100
 %   $
107,783
      
100
 %   $
102,932
      
100
 %
Schedule of Revenue and Operating Income by Geographical Areas [Table Text Block]
    Years Ended December 31,
    2018   2017   2016
    Total
Revenue		   Percentage of
Revenue		   Total
Revenue		   Percentage of
Revenue		   Total
Revenue		   Percentage of
Revenue
Geographic Location:                                                
United States   $
85,351
      
81
 %   $
92,905
      
82
 %   $
83,972
      
81
 %
Europe    
11,730
      
11
 %    
12,435
      
11
 %    
10,953
      
11
 %
Other    
8,474
      
8
 %    
8,080
      
7
 %    
8,454
      
8
 %
Total   $
105,555
      
100
 %   $
113,420
      
100
 %   $
103,379
      
100
 %
Schedule of Revenue from External Customers and Long-Lived Assets, by Geographical Areas [Table Text Block]
    Years Ended December 31,
    2018   2017
United States   $
51,385
     $
52,828
  
Italy    
2,726
      
3,355
  
Total   $
54,111
     $
56,183