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Note 15 - Revenue by Product Group, by Significant Customer and by Geographic Location; Geographic Information (Tables)
 12 Months Ended
Dec. 31, 2016
Notes Tables  
Schedule of Segment Reporting Information, by Segment [Table Text Block]
    Years Ended December 31,
    2016   2015   2014
    Revenue   Percentage
of Product
Revenue		   Revenue   Percentage
of Product
Revenue		   Revenue   Percentage
of Product
Revenue
Orthobiologics   $
89,695
      
87
 %   $
73,247
      
84
 %   $
61,957
      
82
 %
Dermal    
2,759
      
3
 %    
2,266
      
2
 %    
1,334
      
2
 %
Surgical    
5,427
      
5
 %    
5,812
      
7
 %    
5,855
      
8
 %
Other    
5,051
      
5
 %    
6,371
      
7
 %    
6,328
      
8
 %
    $
102,932
      
100
 %   $
87,696
      
100
 %   $
75,474
      
100
 %
Schedule of Revenue and Operating Income by Geographical Areas [Table Text Block]
    Years Ended December 31,
    2016   2015   2014
    Total
Revenue		   Percentage of
Revenue		   Total
Revenue		   Percentage of
Revenue		   Total
Revenue		   Percentage of
Revenue
Geographic Location:                                                
United States   $
83,972
      
81
 %   $
76,621
      
82
 %   $
92,259
      
87
 %
Europe    
10,953
      
11
 %    
8,756
      
9
 %    
6,215
      
6
 %
Other    
8,454
      
8
 %    
7,622
      
9
 %    
7,121
      
7
 %
Total   $
103,379
      
100
 %   $
92,999
      
100
 %   $
105,595
      
100
 %
Schedule of Revenue from External Customers and Long-Lived Assets, by Geographical Areas [Table Text Block]
    Years Ended December 31,
    2016   2015
United States   $
49,140
     $
39,732
  
Italy    
3,156
      
376
  
Total   $
52,296
     $
40,108