Note 16 - Product Revenue by Product Group (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Orthobiologics [Member]
Product revenue	$ 73,247	$ 61,957	$ 55,956
Concentration Risk, Percentage	84.00%	82.00%	78.00%
Dermal [Member]
Product revenue	$ 2,266	$ 1,334	$ 1,817
Concentration Risk, Percentage	2.00%	2.00%	3.00%
Surgical [Member]
Product revenue	$ 5,812	$ 5,855	$ 5,446
Concentration Risk, Percentage	7.00%	8.00%	8.00%
Other [Member]
Product revenue	$ 6,371	$ 6,328	$ 8,555
Concentration Risk, Percentage	7.00%	8.00%	11.00%
Product revenue	$ 87,696	$ 75,474	$ 71,774
Concentration Risk, Percentage	100.00%	100.00%	100.00%