Note 15 - Revenue by Product Group, by Significant Customer and by Geographic Region; Geographic Information

12 Months Ended

Dec. 31, 2014

Segment Reporting [Abstract]

Segment Reporting Disclosure [Text Block]

15. Revenue by Product Group, by Significant Customer and by Geographic Region; Geographic Information

Product revenue by product group is as follows:

	Years Ended December 31,
	2014					2013					2012
	Revenue		Percentage of Product Revenue			Revenue		Percentage of Product Revenue			Revenue		Percentage of Product Revenue
Orthobiologics	$	61,956,870		82	%	$	55,956,068		78	%	$	49,954,112		74	%
Dermal		1,334,295		2	%		1,816,602		3	%		1,384,403		2	%
Surgical		5,854,876		8	%		5,445,715		8	%		5,022,456		7	%
Ophthalmic		3,153,435		4	%		4,656,560		6	%		8,784,011		13	%
Veterinary		3,174,522		4	%		3,898,785		5	%		2,865,187		4	%
	$	75,473,998		100	%	$	71,773,730		100	%	$	68,010,169		100	%

Product revenue by significant customers as a percent of product revenues is as follows:

	Percentage of Product Revenue Years Ended December 31,
	2014			2013			2012
DePuy Mitek		72	%		63	%		61	%
Boehringer		4	%		5	%		4	%
Medtronic XoMEd		4	%		3	%		3	%
Bausch & Lomb		3	%		5	%		12	%
Nordic Pharma		2	%		2	%		1	%
		85	%		78	%		81	%

Total revenue by geographic location based on the location of the customer in total and as a percentage of total revenue are as follows:

	Years Ended December 31,
	2014					2013					2012
	Revenue		Percentage of Total Revenue			Revenue		Percentage of Total Revenue			Revenue		Percentage of Total Revenue
United States	$	92,259,139		87	%	$	58,490,142		78	%	$	57,976,667		81	%
Europe		6,214,441		6	%		7,411,568		10	%		6,218,890		9	%
Other		7,121,259		7	%		9,179,444		12	%		7,162,948		10	%
Total	$	105,594,839		100	%	$	75,081,154		100	%	$	71,358,505		100	%

The Company recorded licensing, milestone and contract revenue of $30,120,841, $3,307,424, and $3,348,336 for the years ended December 31, 2014, 2013, and 2012, respectively. Substantially all licensing, milestone, and contract revenue was derived in the United States for each year presented.

Net long-lived assets, consisting of net property and equipment, are subject to geographic risks because they are generally difficult to move and to effectively utilize in another geographic area in a reasonable time period and because they are relatively illiquid. Net tangible long-lived assets by principal geographic areas were as follows:

	Years Ended December 31,
	2014		2013
United States	$	31,058,617	$	31,999,468
Italy		610,266		939,243
Total	$	31,668,883	$	32,938,711