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Note 9 - Accrued Expenses (Tables)
9 Months Ended
Sep. 30, 2013
Payables and Accruals [Abstract]  
Schedule of Accrued Liabilities [Table Text Block]
   
September 30,
2013
   
December 31,
2012
 
Payroll and benefits
  $ 2,558,293     $ 2,477,833  
Professional fees
    389,672       642,853  
Clinical trial costs
    190,362       102,414  
Restructuring costs
    208,207       933,732  
Other
    1,881,865       1,680,212  
Total
  $ 5,228,399     $ 5,837,044