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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Isox1ckb1493O+0gKLLrYk57etLFOR8lMyb8Z8VY1Ih5aQiOQUS7fvgblKnIbCrj
 TKti8B2Iir39XntnP3sMkg==

<SEC-DOCUMENT>0001193805-05-002597.txt : 20051221
<SEC-HEADER>0001193805-05-002597.hdr.sgml : 20051221
<ACCEPTANCE-DATETIME>20051221130113
ACCESSION NUMBER:		0001193805-05-002597
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20051220
FILED AS OF DATE:		20051221
DATE AS OF CHANGE:		20051221

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			American Caresource Holdings, Inc.
		CENTRAL INDEX KEY:			0001316645
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MISC HEALTH & ALLIED SERVICES, NEC [8090]
		IRS NUMBER:				200428568
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		8080 TRISTAR DRIVE
		STREET 2:		SUITE 100
		CITY:			IRVING
		STATE:			TX
		ZIP:			75063
		BUSINESS PHONE:		972-871-7912

	MAIL ADDRESS:	
		STREET 1:		8080 TRISTAR DRIVE
		STREET 2:		SUITE 100
		CITY:			IRVING
		STATE:			TX
		ZIP:			75063

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	American Caresouce Holdings, Inc.
		DATE OF NAME CHANGE:	20050204

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			PAPPAJOHN JOHN
		CENTRAL INDEX KEY:			0000897464

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51603
		FILM NUMBER:		051277706

	BUSINESS ADDRESS:	
		STREET 1:		C/O EQUITY DYNAMICS
		STREET 2:		2116 FINANCIAL CENTER
		CITY:			DES MOINES
		STATE:			IA
		ZIP:			50309
		BUSINESS PHONE:		631-870-5100

	MAIL ADDRESS:	
		STREET 1:		1660 WALT WHITMAN ROAD
		STREET 2:		SUITE 105
		CITY:			MELVILLE
		STATE:			NY
		ZIP:			11747
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>e501303_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2005-12-20</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001316645</issuerCik>
        <issuerName>American Caresource Holdings, Inc.</issuerName>
        <issuerTradingSymbol>XXXX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000897464</rptOwnerCik>
            <rptOwnerName>PAPPAJOHN JOHN</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EQUITY DYNAMICS</rptOwnerStreet1>
            <rptOwnerStreet2>2116 FINANCIAL CENTER</rptOwnerStreet2>
            <rptOwnerCity>DES MOINES</rptOwnerCity>
            <rptOwnerState>IA</rptOwnerState>
            <rptOwnerZipCode>50309</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4141229</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Warrants</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.40</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2005-01-27</value>
            </exerciseDate>
            <expirationDate>
                <value>2010-01-27</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>653668</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Warrants</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.49</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2005-09-15</value>
            </exerciseDate>
            <expirationDate>
                <value>2010-09-15</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>320248</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Options</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.31</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2005-05-16</value>
            </exerciseDate>
            <expirationDate>
                <value>2015-05-16</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>56233</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The options vest 1/36th per month over a period of 3 years.  As of December 20, 2005, options to purchase 10,934 shares have
 vested.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ John Pappajohn</signatureName>
        <signatureDate>2005-12-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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