-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001017813-05-000049.txt : 20050611
<SEC-HEADER>0001017813-05-000049.hdr.sgml : 20050611
<ACCEPTANCE-DATETIME>20050609141931
ACCESSION NUMBER:		0001017813-05-000049
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050516
FILED AS OF DATE:		20050609
DATE AS OF CHANGE:		20050609

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PATIENT INFOSYSTEMS INC
		CENTRAL INDEX KEY:			0001017813
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MISC HEALTH & ALLIED SERVICES, NEC [8090]
		IRS NUMBER:				161476509
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		46 PRINCE ST
		CITY:			ROCHESTER
		STATE:			NY
		ZIP:			14607
		BUSINESS PHONE:		5852427200

	MAIL ADDRESS:	
		STREET 1:		46 PRINCE ST
		CITY:			ROCHESTER
		STATE:			NY
		ZIP:			14607

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			PAPPAJOHN JOHN
		CENTRAL INDEX KEY:			0000897464

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-22319
		FILM NUMBER:		05887186

	BUSINESS ADDRESS:	
		STREET 1:		C/O EQUITY DYNAMICS
		STREET 2:		2116 FINANCIAL CENTER
		CITY:			DES MOINES
		STATE:			IA
		ZIP:			50309
		BUSINESS PHONE:		631-870-5100

	MAIL ADDRESS:	
		STREET 1:		1660 WALT WHITMAN ROAD
		STREET 2:		SUITE 105
		CITY:			MELVILLE
		STATE:			NY
		ZIP:			11747
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>form4_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-05-16</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001017813</issuerCik>
        <issuerName>PATIENT INFOSYSTEMS INC</issuerName>
        <issuerTradingSymbol>PATY</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000897464</rptOwnerCik>
            <rptOwnerName>PAPPAJOHN JOHN</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EQUITY DYNAMICS</rptOwnerStreet1>
            <rptOwnerStreet2>2116 FINANCIAL CENTER</rptOwnerStreet2>
            <rptOwnerCity>DES MOINES</rptOwnerCity>
            <rptOwnerState>IA</rptOwnerState>
            <rptOwnerZipCode>50309</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2005-05-16</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>X</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>567212</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1.68</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3419772</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Series D Preferred Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2005-05-16</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>X</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>23089</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>10</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>447322</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Net-share exercise of a warrant to purchase 816,667 shares of the Company's common stock using the market price of $5.50 per
share.</footnote>
        <footnote id="F2">Net-share exercise of a warrant to purchase 28,220 shares of the Company's series D preferred stock using the market price of
$5.50 per common equivilent share.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>John Pappajohn</signatureName>
        <signatureDate>2005-06-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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