UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.   20549

SCHEDULE 13D

Under the Securities Exchange Act of 1934
Amendment No. 2

PATIENT INFOSYSTEMS, INC.
(Name of Issuer)

Common Stock
$.01 Par Value Per Share
(Title Class of Securities)

878190115
(CUSIP Number)

Mr. John Pappajohn
2116 Financial Center
Des Moines, Iowa 50309
515-244-5746
(Name, Address and Telephone Number of Person Authorized to
 Receive Notices and Communications)

June 6, 2001
(Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule
13G to report the acquisition which is the subject of this
Schedule 13D, and is filing this schedule because of Rule
13d-1(b)(3) or (4), check the following box:  /  /

Check the following box if a fee is being paid with this
statement: /  /


(1)    NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       John Pappajohn  ###-##-####

(2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

       (a)  /  /
       (b)  /  /

(3)    SEC USE ONLY

(4)    SOURCE OF FUNDS

       PF

(5)    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
       PURSUANT TO ITEMS 2(d) OR 2(e)

       /   /

(6)    CITIZENSHIP OR PLACE OR ORGANIZATION

       U.S.A.

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING
PERSON WITH:

(7)    SOLE VOTING POWER

       4,197,495

(8)    SHARED VOTING POWER

       0

(9)    SOLE DISPOSITIVE POWER

       4,197,495

(10)   SHARED DISPOSITIVE POWER

       0

(11)   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
       PERSON

       4,197,495

(12)   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       CERTAIN SHARES

       /  /

(13)   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

       36.85%

(14)   TYPE OF REPORTING PERSON

       IN


SCHEDULE 13D

This amends and supplements the Statement on Schedule 13D filed
with the Commission by John Pappajohn ("Pappajohn") with
respect to his ownership of Common Stock (the "Common Stock"), $.01
par value per share and Convertible Preferred Stock, Series C, no
par value per share ("Series C Preferred Stock") of Patient
Infosystems, Inc., a Delaware Corporation (the "Company"). Unless
otherwise defined herein, all capitalized items used herein shall
have the meaning ascribed to them in the Statement.


Item 5.     Interest in Securities of the Issuer

(a) As of the date of this statement, Mr. Pappajohn beneficially
owned 4,161,495 shares of Common Stock (assuming the conversion of
50,000 shares of Series C Preferred Stock into 400,000 shares of
Common Stock) and Options to purchase another 36,000 shares of
Common Stock. Such shares of Common Stock and options represent
36.85% of the Company's issued and outstanding shares, assuming
conversion of Pappajohn's Series C Preferred Stock and Options
into Common Stock

(b)  Mr. Pappajohn has sole power to vote or direct the vote
and sole power to dispose or direct the disposition of all shares
of Common Stock and Series C Preferred Stock that he owns.

(c) On June 6, 2001, Mr. Pappajohn was issued 2,189,015 shares of
common stock upon the exercise of his outstanding warrants and in
consideration of his direct loans to the Company and a personal
guarantee on the Company's Line of Credit. In association with
the above transaction, all of Mr. Pappajohn's outstanding
warrants were surrendered to the Company.

     (d - e)  Not applicable.


Item 6.     Contracts, Arrangements, Understandings or
            Relationships with Respect to Securities of Issuer

     Not applicable.


Item 7.     Material to be Filed as Exhibits

     Not applicable.


Item 8.  Certification and Signature:

After reasonable inquiry and to the best of my knowledge and
belief, the undersigned certifies that the information set forth
in this Statement is true, complete and correct.

Dated: June 15, 2001

/s/ John Pappajohn
- -------------------
John Pappajohn