EXHIBIT 11.1

ENCHIRA BIOTECHNOLOGY CORPORATION

BASIC AND DILUTED EARNINGS PER SHARE COMPUTATION

YEAR ENDED DECEMBER 31, 1999

Weighted Average Shares Outstanding:
TOTAL SHARES		# DAYS OUTSTANDING
2,179,124	x	19	=	41,403,356
2,179,713	x	30	=	65,391,390
2,180,358	x	20	=	43,607,160
2,180,691	x	54	=	117,757,314
2,182,661	x	3	=	6,547,983
2,315,663	x	13	=	30,103,619
2,328,667	x	7	=	16,300,669
2,355,070	x	15	=	35,326,050
6,150,401	x	11	=	67,654,411
6,569,890	x	178	=	1,169,440,420
6,572,135	x	15	=	98,582,025
		365		1,692,114,397
				1,692,114,397		/365	=	4,635,930
Loss Per Share:
Net Loss plus dividend accrual plus accretion of offering costs				$	(8,259,546	)	=	$	(1.78	)
Weighted Avg. Shares				4,635,930

1

ENCHIRA BIOTECHNOLOGY CORPORATION

BASIC AND DILUTED EARNINGS PER SHARE COMPUTATION

YEAR ENDED DECEMBER 31, 2000

Weighted Average Shares Outstanding:
TOTAL SHARES		# DAYS OUTSTANDING
6,572,135	x	3	=	19,716,405
6,574,135	x	7	=	46,018,945
6,576,135	x	15	=	98,642,025
6,578,135	x	14	=	92,093,890
6,591,135	x	1	=	6,591,135
6,596,135	x	6	=	39,576,810
6,624,189	x	8	=	52,993,512
6,629,189	x	1	=	6,629,189
6,691,762	x	6	=	40,150,572
6,706,762	x	1	=	6,706,762
6,723,424	x	3	=	20,170,272
6,734,224	x	14	=	94,279,136
6,734,917	x	4	=	26,939,668
6,772,512	x	6	=	40,635,072
7,016,029	x	7	=	49,112,203
7,018,059	x	4	=	28,072,236
7,020,039	x	17	=	119,340,663
7,020,342	x	5	=	35,101,710
7,021,002	x	20	=	140,420,040
7,034,921	x	46	=	323,606,366
7,042,398	x	17	=	119,720,766
7,054,860	x	46	=	324,523,560
9,054,860	x	45	=	407,468,700
9,055,285	x	22	=	199,216,270
9,056,285	x	9	=	81,506,565
9,067,075	x	20	=	181,341,500
9,067,700	x	19	=	172,286,300
		366	=	2,772,860,272
				2,772,860,272		/ 366	=	7,576,121
Loss Per Share:
Net Loss plus dividend accrual plus accretion of offering costs				$	(8,336,096	)	=	$	(1.10	)
Weighted Avg. Shares				7,576,121

2

ENCHIRA BIOTECHNOLOGY CORPORATION

BASIC AND DILUTED EARNINGS PER SHARE COMPUTATION

YEAR ENDED DECEMBER 31, 2001

Weighted Average Shares Outstanding:
TOTAL SHARES		# DAYS OUTSTANDING
9,067,700	x	5	=	45,338,500
9,077,338	x	2	=	18,154,676
9,078,463	x	10	=	90,784,630
9,078,888	x	22		199,735,536
9,079,313	x	53	=	481,203,589
9,267,993	x	45	=	417,059,685
9,278,711	x	82	=	760,854,302
9,280,821	x	37	=	343,390,377
10,170,739	x	17	=	172,902,563
10,207,890	x	23	=	234,781,470
10,231,756	x	28	=	286,489,168
10,360,026	x	14	=	145,040,364
10,837,354	x	10	=	108,373,540
10,843,320	x	17	=	184,336,440
		365		3,488,444,840
				3,488,444,840		/365	=	9,557,383
Loss Per Share:
Net Loss plus dividend accrualplus accretion of offering costs				$	(9,027,019	)	=	$	(0.94	)
Weighted Avg. Shares				9,557,383

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