June 2022

Preliminary Terms No. 5,454

Registration Statement Nos. 333-250103; 333-250103-01

Dated June 14, 2022

Filed pursuant to Rule 433

Morgan Stanley Finance LLC

Structured Investments

Opportunities in Commodities

Commodity-Linked Notes Based on the Performance of a Basket of Eight Commodities due December 27, 2024

Fully and Unconditionally Guaranteed by Morgan Stanley

The notes are unsecured obligations of Morgan Stanley Finance LLC (“MSFL”) and are fully and unconditionally guaranteed by Morgan Stanley.  The notes will pay no interest and have the terms described in the accompanying prospectus supplement and prospectus, as supplemented or modified by this document.  At maturity, we will pay per note the stated principal amount of $1,000 plus a supplemental redemption amount, if any, based on the performance of an equally-weighted basket of physical commodities.  The notes are for investors who are concerned about principal risk, but seek a commodity based-return and who are willing to forgo current income in exchange for the repayment of principal at maturity plus the potential to receive a supplemental redemption amount, if any.  The notes are notes issued as part of MSFL’s Series A Global Medium-Term Notes program.

All payments are subject to our credit risk.  If we default on our obligations, you could lose some or all of your investment.  These notes are not secured obligations and you will not have any security interest in, or otherwise have any access to, any underlying reference asset or assets.

SUMMARY TERMS
Issuer:	Morgan Stanley Finance LLC
Guarantor:	Morgan Stanley
Issue price:	$1,000 per note
Stated principal amount:	$1,000 per note
Pricing date:	June 21, 2022
Original issue date:	June 24, 2022 (3 business days after the pricing date)
Maturity date:	December 27, 2024
Aggregate principal amount:	$

Basket:	Basket commodity	Bloomberg ticker symbol*	Weighting	Initial basket commodity price
	West Texas Intermediate light sweet crude oil futures contracts (“WTI crude oil”)	CL1	12.50%	$
	Brent crude oil (“Brent crude oil”)	CO1	12.50%	$
	Natural gas (“Natural gas”)	NG1	12.50%	$
	Corn – CBOT (“corn”)	C 1	12.50%	¢
	Soybeans – CBOT (“soybeans”)	S 1	12.50%	¢
	Wheat – CBOT (“wheat”)	W 1	12.50%	¢
	Copper grade A (“copper”)	LOCADY	12.50%	$
	Zinc	LOZSDY	12.50%	$

* Bloomberg ticker symbols are being provided for reference purposes only.  The initial basket commodity price and the final basket commodity price for each basket commodity will be determined based on the values published by the relevant exchange and, notwithstanding the Bloomberg ticker symbols provided for reference purposes above, such prices (in the case of WTI crude oil, Brent crude oil, natural gas, corn, soybeans and wheat) may be based on the second nearby month futures contract, as further described under “Commodity price” on page 2.

Payment at maturity:	The payment at maturity per $1,000 stated principal amount will equal: $1,000 + supplemental redemption amount, if any In no event will the payment at maturity per $1,000 stated principal amount be less than $1,000.
Supplemental redemption amount:	$1,000 × participation rate × basket performance; provided that the supplemental redemption amount will not be less than zero.
Participation rate:	101%
Basket performance:	The sum of the commodity performance values of each of the basket commodities
Commodity performance value:	With respect to each basket commodity: [(final commodity price – initial commodity price) / initial commodity price] × weighting
Determination date:	In respect of each basket commodity, December 23, 2024, subject to adjustment for a non-trading day or a market disruption event in respect of the applicable basket commodity.
Interest:	None
CUSIP / ISIN:	61773QWD7 / US61773QWD77
No listing:	The notes will not be listed on any securities exchange.
Agent:	Morgan Stanley & Co. LLC (“MS & Co.”), an affiliate of MSFL and a wholly owned subsidiary of Morgan Stanley.  See “Supplemental information concerning plan of distribution; conflicts of interest.”
Estimated value on the pricing date:	Approximately $939.30 per note, or within $39.30 of that estimate.  See “Investment Summary” on page 3.
	Terms continued on the following page

Commissions and issue price:	Price to public	Agent’s commissions and fees	Proceeds to us(3)
Per security	$1,000	$25(1)
		$5(2)	$970
Total	$	$	$

(1) Selected dealers, including Morgan Stanley Wealth Management (an affiliate of the agent), and their financial advisors will collectively receive from the agent, MS & Co., a fixed sales commission of $25 for each note they sell. See “Supplemental information concerning plan of distribution; conflicts of interest.” For additional information, see “Plan of Distribution (Conflicts of Interest)” in the accompanying prospectus supplement.

(2) Reflects a structuring fee payable to Morgan Stanley Wealth Management by the agent or its affiliates of $5 for each note.

(3) See “Use of proceeds and hedging” on page 27.

The notes involve risks not associated with an investment in ordinary debt securities.  See “Risk Factors” beginning on page 10.

The Securities and Exchange Commission and state securities regulators have not approved or disapproved these securities, or determined if this document or the accompanying prospectus supplement and prospectus is truthful or complete.  Any representation to the contrary is a criminal offense.
The notes are not deposits or savings accounts and are not insured by the Federal Deposit Insurance Corporation or any other governmental agency or instrumentality, nor are they obligations of, or guaranteed by, a bank.
You should read this document together with the related prospectus supplement and prospectus, each of which can be accessed via the hyperlinks below.  Please also see “Additional Terms of the Notes” and “Additional Information About the Notes” at the end of this document.

As used in this document, “we,” “us” and “our” refer to Morgan Stanley or MSFL, or Morgan Stanley and MSFL collectively, as the context requires.

Prospectus Supplement for Commodity-Linked Notes dated November 16, 2020 Prospectus dated November 16, 2020

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Terms continued from previous page:
Commodity price:	For any trading day: WTI crude oil: the official settlement price per barrel of West Texas Intermediate light sweet crude oil on the relevant exchange of the first nearby month futures contract, stated in U.S. dollars, as made public by the relevant exchange on such date, provided that if such date falls on the last trading day of such futures contract (all pursuant to the rules of the relevant exchange), then the second nearby month futures contract on such date. Brent crude oil: the official settlement price per barrel of Brent blend crude oil on the relevant exchange of the first nearby month futures contract, stated in U.S. dollars, as made public by the relevant exchange on such date, provided that if such date falls on the last trading day of such futures contract (all pursuant to the rules of the relevant exchange), then the second nearby month futures contract on such date. Natural gas: the official settlement price per one million British thermal units of natural gas on the relevant exchange of the first nearby month futures contract, stated in U.S. dollars, as made public by the relevant exchange on such date, provided that if such date falls on the last trading day of such futures contract (all pursuant to the rules of the relevant exchange), then the second nearby month futures contract on such date. Corn: the official settlement price per bushel of deliverable-grade corn on the relevant exchange of the first nearby month futures contract (or, in the case of any trading day after the date of the last trade of the options contract (if there is more than one options contract, then the options contract with the latest date) pertaining to the first nearby month futures contract, the second nearby month futures contract), stated in U.S. cents, as made public by the relevant exchange on such date. Soybeans: the official settlement price per bushel of deliverable-grade soybeans on the relevant exchange of the first nearby month futures contract (or, in the case of any trading day after the date of the last trade of the options contract (if there is more than one options contract, then the options contract with the latest date) pertaining to the first nearby month futures contract, the second nearby month futures contract), stated in U.S. cents, as made public by relevant exchange on such date. Wheat: the official settlement price per bushel of deliverable-grade wheat on the relevant exchange of the first nearby month futures contract (or, in the case of any trading day after the date of the last trade of the options contract (if there is more than one options contract, then the options contract with the latest date) pertaining to the first nearby month futures contract, the second nearby month futures contract), stated in U.S. cents, as made public by the relevant exchange on such date. Copper: the official cash offer price per tonne of copper grade A on the relevant exchange for the spot market, stated in U.S. dollars, as determined by the relevant exchange on such date. Zinc: the official cash offer price per tonne of special high grade zinc on the relevant exchange for the spot market, stated in U.S. dollars, as determined by the relevant exchange on such date.
Relevant exchange:	WTI crude oil: the NYMEX Division, or its successor, of the NYMEX Brent crude oil: the ICE Futures Europe Natural gas: the NYMEX Division, or its successor, of the NYMEX Corn: the Chicago Board of Trade Soybeans: the Chicago Board of Trade Wheat: the Chicago Board of Trade Copper: the London Metal Exchange Zinc: the London Metal Exchange
Initial basket commodity price:	The commodity price for the applicable basket commodity on the pricing date, as set forth under “Basket—Initial basket commodity price” above.
Final basket commodity price:	The commodity price for the applicable basket commodity on the determination date, subject to adjustment for each basket commodity individually in the event of a market disruption event or a non-trading day.

June 2022 Page 2

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Investment Summary

The Commodity-Linked Notes due December 27, 2024 (the “notes”) offer 101% participation in the positive performance of the basket and provide investors:

§ an opportunity to gain exposure to the basket

§ the repayment of principal at maturity, subject to our credit risk

§ 101% participation in any appreciation of the basket over the term of the notes

§ no exposure to any decline of the basket if the notes are held to maturity

At maturity, if the basket has depreciated or has not appreciated at all, you will receive the stated principal amount of $1,000 per note, without any positive return on your investment.  All payments on the notes, including the repayment of principal at maturity, are subject to our credit risk.

Maturity:	Approximately 2.5 years
Participation rate:	101%
Maximum payment at maturity:	None
Basket weighting:	12.50% for each basket commodity
Interest:	None

The original issue price of each note is $1,000.  This price includes costs associated with issuing, selling, structuring and hedging the notes, which are borne by you, and, consequently, the estimated value of the notes on the pricing date will be less than $1,000.  We estimate that the value of each note on the pricing date will be approximately $939.30, or within $39.30 of that estimate.  Our estimate of the value of the notes as determined on the pricing date will be set forth in the final pricing supplement.

What goes into the estimated value on the pricing date?

In valuing the notes on the pricing date, we take into account that the notes comprise both a debt component and a performance-based component linked to the basket commodities.  The estimated value of the notes is determined using our own pricing and valuation models, market inputs and assumptions relating to the basket commodities, instruments based on the basket commodities, volatility and other factors including current and expected interest rates, as well as an interest rate related to our secondary market credit spread, which is the implied interest rate at which our conventional fixed rate debt trades in the secondary market.

What determines the economic terms of the notes?

In determining the economic terms of the notes, including the participation rate, we use an internal funding rate, which is likely to be lower than our secondary market credit spreads and therefore advantageous to us.  If the issuing, selling, structuring and hedging costs borne by you were lower or if the internal funding rate were higher, one or more of the economic terms of the notes would be more favorable to you.

What is the relationship between the estimated value on the pricing date and the secondary market price of the notes?

The price at which MS & Co. purchases the notes in the secondary market, absent changes in market conditions, including those related to the basket commodities, may vary from, and be lower than, the estimated value on the pricing date, because the secondary market price takes into account our secondary market credit spread as well as the bid-offer spread that MS & Co. would charge in a secondary market transaction of this type and other factors.

MS & Co. may, but is not obligated to, make a market in the notes and, if it once chooses to make a market, may cease doing so at any time.

June 2022 Page 3

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Key Investment Rationale

At maturity, we will pay per note the stated principal amount of $1,000 plus a supplemental redemption amount, if any, based on the performance of an equally-weighted basket of physical commodities.  The notes are for investors who are concerned about principal risk, but seek a commodity based-return and who are willing to forgo current income in exchange for the repayment of principal at maturity plus the potential to receive a supplemental redemption amount, if any.  All payments are subject to our credit risk.

Repayment of Principal	The notes offer investors 1.01-to-1 upside exposure to the performance of the basket while providing for the repayment of principal in full at maturity.
Upside Scenario	The basket increases in value and, at maturity, you receive an amount per note equal to the sum of (i) the stated principal amount of $1,000 and (ii) 101% of the increase in the value of the basket.
Par Scenario	The basket declines or does not appreciate in value and, at maturity, you receive only the stated principal amount of $1,000 per note.

June 2022 Page 4

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Key Investment Rationale

At maturity, for each $1,000 stated principal amount of notes that you hold, you will receive the stated principal amount of $1,000 plus a supplemental redemption amount, if any, calculated on the determination date as follows:

(i) $1,000 times (ii) the participation rate times (iii) the basket performance, provided that the supplemental redemption amount will not be less than zero.

The table below illustrates the payment at maturity for each note (including, where relevant, the supplemental redemption amount) for a hypothetical range of basket performances and does not cover the complete range of possible payouts at maturity.

Basket performance	Stated principal amount	Supplemental redemption amount	Payment at maturity	Percent return on $1,000 note
100%	$1,000	$1,010.00	$2,010.00	101.00%
90%	$1,000	$909.00	$1,909.00	90.90%
80%	$1,000	$808.00	$1,808.00	80.80%
70%	$1,000	$707.00	$1,707.00	70.70%
60%	$1,000	$606.00	$1,606.00	60.60%
50%	$1,000	$505.00	$1,505.00	50.50%
40%	$1,000	$404.00	$1,404.00	40.40%
30%	$1,000	$303.00	$1,303.00	30.30%
20%	$1,000	$202.00	$1,202.00	20.20%
15%	$1,000	$151.50	$1,151.50	15.15%
10%	$1,000	$101.00	$1,101.00	10.10%
5%	$1,000	$50.50	$1,050.50	5.05%
0%	$1,000	$0	$1,000	0%
-10%	$1,000	$0	$1,000	0%
-20%	$1,000	$0	$1,000	0%
-30%	$1,000	$0	$1,000	0%
-40%	$1,000	$0	$1,000	0%
-50%	$1,000	$0	$1,000	0%
-60%	$1,000	$0	$1,000	0%
-70%	$1,000	$0	$1,000	0%
-80%	$1,000	$0	$1,000	0%
-90%	$1,000	$0	$1,000	0%
-100%	$1,000	$0	$1,000	0%

How it works

§ Upside Scenario.  If the basket performance is positive, investors would receive the $1,000 stated principal amount per note plus 101% of the appreciation of the basket over the term of the notes.

§ For example, if the basket appreciates 10%, the investor would receive a 10.10% return, or $1,101 per note.

§ Par Scenario.  If the basket performance is less than or equal to 0%, investors would receive the $1,000 stated principal amount per note.

June 2022 Page 5

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Calculation of the Payment at Maturity

Basket Appreciation Example 1

Below is an example of how to calculate the payment at maturity if the basket has appreciated.  This example is based on the participation rate of 101% and the hypothetical data in the table below.  The initial and final basket commodity prices below are hypothetical and do not reflect the actual initial or final basket commodity price for any basket commodity.  The numbers appearing below may have been rounded for ease of analysis.  As the basket has appreciated in value, the basket performance is positive and the payment at maturity includes a supplemental redemption amount based on the performance of the basket.

Basket commodity	Weight in Basket	Hypothetical Initial basket commodity price	Hypothetical Final basket commodity price	Percentage Change
WTI crude oil	12.50%	$100	$120	20%
Brent crude oil	12.50%	$100	$90	-10%
Natural gas	12.50%	$7.00	$5.25	-25%
Corn	12.50%	800¢	880¢	10%
Soybeans	12.50%	1,600¢	1,520¢	-5%
Wheat	12.50%	1,000¢	1,400¢	40%
Copper	12.50%	$10,000	$11,000	10%
Zinc	12.50%	$2,000	$1,800	-10%

Basket performance = sum of the products of (x) the final basket commodity price for each basket commodity minus the initial basket commodity price for such basket commodity divided by the initial basket commodity price of such basket commodity and (y) the basket commodity weighting for such basket commodity:

[(final WTI crude oil price – initial WTI crude oil price) / initial WTI crude oil price]  ×  12.50%; plus 

[(final Brent crude oil price – initial Brent crude oil price) / initial Brent crude oil price]  ×  12.50%; plus 

[(final natural gas price – initial natural gas price) / initial natural gas price]  ×  12.50%; plus 

[(final corn price – initial corn price) / initial corn price]  ×  12.50%; plus 

[(final soybeans price – initial soybeans price) / initial soybeans price]  ×  12.50%; plus 

[(final wheat price – initial wheat price) / initial wheat price]  ×  12.50%; plus 

[(final copper price – initial copper price) / initial copper price]  ×  12.50%; plus 

[(final zinc price – initial zinc price) / initial zinc price]  ×  12.50%

So, using the final basket commodity prices above:

WTI crude oil =  [($120 - $100) / $100]  ×  12.50%  =  2.50%; plus 

Brent crude oil =  [($90 - $100) / $100]  ×  12.50%  =  -1.25%; plus 

Natural gas =  [($5.25 - $7.00) / $7.00]  ×  12.50%  =  -3.125%; plus 

corn =  [(880¢ - 800¢) / 800¢]  ×  12.50%  =  1.25%; plus 

soybeans =  [(1,520¢ - 1,600¢) / 1,600¢]  ×  12.50%  =  -0.625%; plus 

wheat =  [(1,400¢ - 1,000¢) / 1,000¢]  ×  12.50%  =  5.00%; plus 

copper =  [($11,000 - $10,000) / $10,000]  ×  12.50%  =  1.25%; plus 

zinc =  [($1,800 – $2,000) / $2,000]  ×  12.50%  =  -1.25%

which equals

basket performance =   3.75%

The payment at maturity will equal $1,000 plus the supplemental redemption amount.  The supplemental redemption amount will equal (i) $1,000 times (ii) the participation rate times (iii) the basket performance, or:

$1,000   ×   101.00%   ×   3.75%   =   $37.875

The payment at maturity will equal $1,000 plus the supplemental redemption amount, or:

$1,000   +   $37.875   =   $1,037.875

June 2022 Page 6

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Basket Appreciation Example 2

Below is an example of how to calculate the payment at maturity if the basket has appreciated.  This example is based on the participation rate of 101% and the hypothetical data in the table below.  The initial and final basket commodity prices below are hypothetical and do not reflect the actual initial or final basket commodity price for any basket commodity.  The numbers appearing below may have been rounded for ease of analysis.  In this example, although six basket components have depreciated or remained unchanged over the term of the notes, the appreciation of the other two components is great enough to mean that the basket has appreciated in value.  As a result, the basket performance is positive and the payment at maturity includes a supplemental redemption amount based on the performance of the basket.

Basket commodity	Weight in Basket	Hypothetical Initial basket commodity price	Hypothetical Final basket commodity price	Percentage Change
WTI crude oil	12.50%	$100	$95	-5%
Brent crude oil	12.50%	$100	$95	-5%
Natural gas	12.50%	$7.00	$6.65	-5%
Corn	12.50%	800¢	800¢	0%
Soybeans	12.50%	1,600¢	1,520¢	-5%
Wheat	12.50%	1,000¢	1,400¢	40%
Copper	12.50%	$10,000	$16,000	60%
Zinc	12.50%	$2,000	$1,800	-10%

Basket performance = sum of the products of (x) the final basket commodity price for each basket commodity minus the initial basket commodity price for such basket commodity divided by the initial basket commodity price of such basket commodity and (y) the basket commodity weighting for such basket commodity:

[(final WTI crude oil price – initial WTI crude oil price) / initial WTI crude oil price]  × 12.50%; plus 

[(final Brent crude oil price – initial Brent crude oil price) / initial Brent crude oil price]  × 12.50%; plus

[(final natural gas price – initial natural gas price) / initial natural gas price]  × 12.50%; plus

[(final corn price – initial corn price) / initial corn price]  × 12.50%; plus

[(final soybeans price – initial soybeans price) / initial soybeans price]  × 12.50%; plus

[(final wheat price – initial wheat price) / initial wheat price]  × 12.50%; plus

[(final copper price – initial copper price) / initial copper price]  × 12.50%; plus

[(final zinc price – initial zinc price) / initial zinc price]  × 12.50%

So, using the final basket commodity prices above:

WTI crude oil =  [($95 - $100) / $100] × 12.50%  =  -0.625%; plus 

Brent crude oil =  [($95 - $100) / $100] × 12.50%  =  -0.625%; plus 

Natural gas =  [($6.65 - $7.00) / $7.00] × 12.50%  =  -0.625%; plus 

corn =  [(800¢ - 800¢) / 800¢] × 12.50%  =  0%; plus 

soybeans =  [(1,520¢ - 1,600¢) / 1,600¢] × 12.50%  =  -0.625%; plus 

wheat =  [(1,400¢ - 1,000¢) / 1,000¢] × 12.50%  =  5.00%; plus

copper =  [($16,000 - $10,000) / $10,000] × 12.50%  =  7.50%; plus

zinc =  [($1,800 – $2,000) / $2,000] × 12.50%  =  -1.25%

which equals

basket performance =   8.75%

June 2022 Page 7

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

In the above example, the final basket commodity price of each of the basket components except for wheat and copper is lower than its respective initial basket commodity price.  Accordingly, although the final basket commodity prices of 75% of the basket commodities (by weight) have decreased in value over their respective initial basket commodity prices, the final basket commodity prices of the other 25% (by weight) of the basket have increased and, because they have increased significantly, their increase more than offsets the declines in the other basket commodities and, consequently, the basket performance is positive.  The payment at maturity per note will equal $1,000 plus the supplemental redemption amount; or:

The payment at maturity will equal $1,000 plus the supplemental redemption amount.  The supplemental redemption amount will equal (i) $1,000 times (ii) the participation rate times (iii) the basket performance, or:

$1,000   ×   101.00%   ×   8.75%   =   $88.375

The payment at maturity will equal $1,000 plus the supplemental redemption amount, or:

$1,000   +   $88.375   =   $1,088.375

Par Example

If the basket performance is less than or equal to 0%, the payment at maturity will equal only the stated principal amount.  Below is an example of a scenario in which the basket performance is less than 0% based on the hypothetical data in the table below.  The initial and final basket commodity prices below are hypothetical and do not reflect the actual initial or final basket commodity price for any basket commodity.  The numbers appearing below may have been rounded for ease of analysis.

Basket commodity	Weight in Basket	Hypothetical Initial basket commodity price	Hypothetical Final basket commodity price	Percentage Change
WTI crude oil	12.50%	$100	$90	-10%
Brent crude oil	12.50%	$100	$90	-10%
Natural gas	12.50%	$7	$5.60	-20%
Corn	12.50%	800¢	600¢	-25%
Soybeans	12.50%	1,600¢	1,440¢	-10%
Wheat	12.50%	1,000¢	850¢	-15%
Copper	12.50%	$10,000	$9,000	-10%
Zinc	12.50%	$2,000	$1,800	-10%

Basket performance = sum of the products of (x) the final basket commodity price for each basket commodity minus the initial basket commodity price for such basket commodity divided by the initial basket commodity price of such basket commodity and (y) the basket commodity weighting for such basket commodity:

[(final WTI crude oil price – initial WTI crude oil price) / initial WTI crude oil price]  × 12.50%; plus

[(final Brent crude oil price – initial Brent crude oil price) / initial Brent crude oil price]  × 12.50%; plus

[(final natural gas price – initial natural gas price) / initial natural gas price]  × 12.50%; plus

[(final corn price – initial corn price) / initial corn price]  × 12.50%; plus

[(final soybeans price – initial soybeans price) / initial soybeans price]  × 12.50%; plus

[(final wheat price – initial wheat price) / initial wheat price]  × 12.50%; plus

[(final copper price – initial copper price) / initial copper price]  × 12.50%; plus

[(final zinc price – initial zinc price) / initial zinc price]  × 12.50%

June 2022 Page 8

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

So, using the final basket commodity prices above:

WTI crude oil =  [($90 - $100) / $100] × 12.50%  =  -1.25%; plus 

Brent crude oil =  [($90 - $100) / $100] × 12.50%  =  -1.25%; plus

Natural gas =  [($5.60 - $7.00) / $7.00] × 12.50%  =  -2.50%; plus

corn =  [(600¢ - 800¢) / 800¢] × 12.50%  =  -3.125%; plus

soybeans =  [(1,440¢ - 1,600¢) / 1,600¢] × 12.50%  =  -1.25%; plus

wheat =  [(850¢ - 1,000¢) / 1,000¢] × 12.50%  =  -1.875%; plus

copper =  [($9,000 - $10,000) / $10,000] × 12.50%  =  -1.25%; plus

zinc =  [($1,800 – $2,000) / $2,000] × 12.50%  =  -1.25%

which equals

basket performance   =   -13.75%

In the above example, the final commodity price of each of the basket components is lower than its respective initial basket commodity price and the basket performance is negative.  The payment at maturity will equal $1,000.

June 2022 Page 9

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Risk Factors

This section describes the material risks relating to the notes.  For further discussion of these and other risks, you should read the section entitled “Risk Factors” in the accompanying prospectus supplement and prospectus.  We also urge you to consult your investment, legal, tax, accounting and other advisers in connection with your investment in the notes.

Risks Relating to an Investment in the Notes

§ The notes do not pay interest and may not pay more than the stated principal amount at maturity.  If the basket performance is less than or equal to 0%, you will receive only the stated principal amount of $1,000 for each note you hold at maturity.  As the notes do not pay any interest, if the basket does not appreciate sufficiently over the term of the notes, the overall return on the notes (the effective yield to maturity) may be less than the amount that would be paid on a conventional debt security of ours of comparable maturity. The notes are for investors who are concerned about principal risk, but seek a commodity based-return and who are willing to forgo current income in exchange for the repayment of principal at maturity plus the potential to receive a supplemental redemption amount, if any.

§ The market price of the notes may be influenced by many unpredictable factors. Several factors, many of which are beyond our control, will influence the value of the notes in the secondary market and the price at which we or certain of our affiliates, including Morgan Stanley & Co. LLC (“MS & Co.”), may be willing to purchase or sell the notes in the secondary market, including: the price of each of the basket commodities at any time and, in particular, on the valuation date, the volatility (frequency and magnitude of changes in value) of each of the basket commodities, interest and yield rates in the market, geopolitical conditions and economic, financial, political, regulatory or judicial events that affect the basket commodities or commodities markets in general and which may affect the final basket commodity prices of the basket commodities, trends of supply and demand for the basket commodities, as well as the effects of speculation or any government activity that could affect the commodities markets, the time remaining until the notes mature and any actual or anticipated changes in our credit ratings or credit spreads. In addition, the commodities markets are subject to temporary distortions or other disruptions due to various factors, including lack of liquidity, participation of speculators and government intervention. As a result, the market value of the notes will vary and may be less than the original issue price at any time prior to maturity and sale of the notes prior to maturity may result in a loss.

§ The notes are subject to our credit risk, and any actual or anticipated changes to our credit ratings or credit spreads may adversely affect the market value of the notes.  You are dependent on our ability to pay all amounts due on the notes at maturity and therefore you are subject to our credit risk.  If we default on our obligations under the notes, your investment would be at risk and you could lose some or all of your investment. As a result, the market value of the notes prior to maturity will be affected by changes in the market’s view of our creditworthiness. Any actual or anticipated decline in our credit ratings or increase in the credit spreads charged by the market for taking our credit risk is likely to adversely affect the market value of the notes.

§ As a finance subsidiary, MSFL has no independent operations and will have no independent assets.  As a finance subsidiary, MSFL has no independent operations beyond the issuance and administration of its securities and will have no independent assets available for distributions to holders of MSFL securities if they make claims in respect of such securities in a bankruptcy, resolution or similar proceeding.  Accordingly, any recoveries by such holders will be limited to those available under the related guarantee by Morgan Stanley and that guarantee will rank pari passu with all other unsecured, unsubordinated obligations of Morgan Stanley.  Holders will have recourse only to a single claim against Morgan Stanley and its assets under the guarantee.  Holders of securities issued by MSFL should accordingly assume that in any such proceedings they would not have any priority over and should be treated pari passu with the claims of other unsecured, unsubordinated creditors of Morgan Stanley, including holders of Morgan Stanley-issued securities.

§ The amount payable on the notes is not linked to the price of the basket commodities at any time other than the determination date.  The final basket commodity price for each basket commodity will be the commodity price for such basket commodity on the determination date, subject to postponement for non-trading days and certain market disruption events.  Even if the prices of the basket commodities appreciate prior to the determination date but then drop by the determination date, the payment at maturity will be less, and may be significantly less, than it would have

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been had the payment at maturity been linked to the price of the basket commodities prior to such drop.  Although the actual prices of the basket commodities on the stated maturity date or at other times during the term of the notes may be higher than the final commodity prices, the payment at maturity will be based solely on the commodity prices on the determination date.

§ The rate we are willing to pay for securities of this type, maturity and issuance size is likely to be lower than the rate implied by our secondary market credit spreads and advantageous to us.  Both the lower rate and the inclusion of costs associated with issuing, selling, structuring and hedging the notes in the original issue price reduce the economic terms of the notes, cause the estimated value of the notes to be less than the original issue price and will adversely affect secondary market prices.  Assuming no change in market conditions or any other relevant factors, the prices, if any, at which dealers, including MS & Co., may be willing to purchase the notes in secondary market transactions will likely be significantly lower than the original issue price, because secondary market prices will exclude the issuing, selling, structuring and hedging-related costs that are included in the original issue price and borne by you and because the secondary market prices will reflect our secondary market credit spreads and the bid-offer spread that any dealer would charge in a secondary market transaction of this type as well as other factors.

The inclusion of the costs of issuing, selling, structuring and hedging the notes in the original issue price and the lower rate we are willing to pay as issuer make the economic terms of the notes less favorable to you than they otherwise would be.

§ The estimated value of the notes is determined by reference to our pricing and valuation models, which may differ from those of other dealers and is not a maximum or minimum secondary market price.  These pricing and valuation models are proprietary and rely in part on subjective views of certain market inputs and certain assumptions about future events, which may prove to be incorrect.  As a result, because there is no market-standard way to value these types of securities, our models may yield a higher estimated value of the notes than those generated by others, including other dealers in the market, if they attempted to value the notes.  In addition, the estimated value on the pricing date does not represent a minimum or maximum price at which dealers, including MS & Co., would be willing to purchase your notes in the secondary market (if any exists) at any time. The value of your notes at any time after the date of this document will vary based on many factors that cannot be predicted with accuracy, including our creditworthiness and changes in market conditions.  See also “The market price will be influenced by many unpredictable factors” above.

§ Investing in the notes is not equivalent to investing in the basket commodities or in futures contracts or forward contracts on the basket commodities.  By purchasing the notes, you do not purchase any entitlement to any of the basket commodities or futures contracts or forward contracts on any of the basket commodities.  Further, by purchasing the notes, you are taking credit risk to us and not to any counter-party to futures contracts or forward contracts on the basket commodities.

§ The notes will not be listed on any securities exchange and secondary trading may be limited. Accordingly, you should be willing to hold your notes for the entire term of the notes.  The notes will not be listed on any securities exchange.  Therefore, there may be little or no secondary market for the notes.  MS & Co. may, but is not obligated to, make a market in the notes and, if it once chooses to make a market, may cease doing so at any time. When it does make a market, it will generally do so for transactions of routine secondary market size at prices based on its estimate of the current value of the notes, taking into account its bid/offer spread, our credit spreads, market volatility, the notional size of the proposed sale, the cost of unwinding any related hedging positions, the time remaining to maturity and the likelihood that it will be able to resell the notes.  Even if there is a secondary market, it may not provide enough liquidity to allow you to trade or sell the notes easily.  Since other broker-dealers may not participate significantly in the secondary market for the notes, the price at which you may be able to trade your notes is likely to depend on the price, if any, at which MS & Co. is willing to transact.  If, at any time, MS & Co. were to cease making a market in the notes, it is likely that there would be no secondary market for the notes.  Accordingly, you should be willing to hold your notes to maturity.

§ The calculation agent, which is a subsidiary of Morgan Stanley and an affiliate of MSFL, will make determinations with respect to the notes.  As calculation agent, Morgan Stanley Capital Group Inc. (“MSCG”) will determine the initial basket commodity price, the final basket commodity price and the commodity performance value for each basket commodity, the basket performance, the supplemental redemption amount, if any, and whether a market disruption event has occurred.  Additionally, the calculation agent will calculate the amount of cash you will

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receive at maturity.  Moreover, certain determinations made by MSCG, in its capacity as calculation agent, may require it to exercise discretion and make subjective judgments, such as with respect to the occurrence or non-occurrence of market disruption events or calculation of any commodity price in the event of a market disruption event. These potentially subjective determinations may adversely affect the payout to you at maturity.  For further information regarding these types of determinations, see “Payment at Maturity—Calculation Agent and Calculations” and “—Alternate Exchange Calculation in the Case of an Event of Default” and related definitions in the accompanying prospectus supplement.  In addition, MS & Co. has determined the estimated value of the notes on the pricing date.

§ Hedging and trading activity by our affiliates could potentially adversely affect the value of the notes.  One or more of our affiliates and/or third-party dealers expect to carry out hedging activities related to the notes (and possibly to other instruments related or linked to the basket commodities), including trading in the basket commodities or futures contracts or forward contracts on the basket commodities.  As a result, these entities may be unwinding or adjusting hedge positions during the term of the notes, and the hedging strategy may involve greater and more frequent dynamic adjustments to the hedge as the determination date approaches.  Some of our affiliates also trade the basket commodities on a regular basis as part of their general broker-dealer, commodity trading, proprietary trading and other businesses.

Any of these hedging or trading activities on or prior to the pricing date could potentially increase the initial basket commodity prices and, therefore, could increase the prices at or above which the basket commodities must close on the determination date before you would receive at maturity a payment that exceeds the stated principal amount of the notes.  Additionally, such hedging or trading activities during the term of the notes, including on the determination date, could adversely affect the basket commodity prices on the determination date and, accordingly, the amount of cash you will receive at maturity.

Risks Relating to the Basket Components

§ Changes in the price of one or more of the basket commodities may offset each other.  Price movements in the basket commodities may not correlate with each other.  At a time when the price of one basket commodity increases, the price of the other basket commodities may not increase as much, or may even decline.  Therefore, in calculating the performance of the basket commodities on the determination date, increases in the price of one basket commodity may be moderated, or wholly offset, by lesser increases or declines in the price of the other basket commodities.  

§ Specific commodities’ prices are volatile and are affected by numerous factors specific to each market.  Investments, such as the notes, linked to the prices of commodities, such as the basket commodities, are subject to sharp fluctuations in the prices of commodities over short periods of time for a variety of factors, including the principal factors set out below:

WTI crude oil.  Demand for refined petroleum products by consumers, as well as by the agricultural, manufacturing and transportation industries, affects the price of crude oil.  Crude oil’s end-use as a refined product is often as transport fuel, industrial fuel and in-home heating fuel.  Potential for substitution in most areas exists, although considerations including relative cost often limit substitution levels.  Because the precursors of demand for petroleum products are linked to economic activity, demand will tend to reflect economic conditions.  Demand is also influenced by government regulations, such as environmental or consumption policies.  In addition to general economic activity and demand, prices for crude oil are affected by political events, labor activity, developments in production technology such as fracking and, in particular, direct government intervention (such as embargos) or supply disruptions in major oil producing regions of the world.  Such events tend to affect oil prices worldwide, regardless of the location of the event.  Supply for crude oil may increase or decrease depending on many factors.  These include production decisions by the Organization of the Petroleum Exporting Countries and other crude oil producers.  In the event of sudden disruptions in the supplies of oil, such as those caused by war, natural events, accidents, acts of terrorism or cyberattacks, prices of oil futures contracts could become extremely volatile and unpredictable.  Also, sudden and dramatic changes in the futures market may occur, for example, upon a cessation of hostilities that may exist in countries producing oil, the introduction of new or previously withheld supplies into the market or the introduction of substitute products or commodities.  WTI crude oil is also subject to the risk that it has demonstrated a lack of correlation with world crude oil prices due to structural differences

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between the U.S. market for crude oil and the international market for crude oil.  As a result, the price of WTI crude oil may be more volatile than world crude oil prices generally.

In addition, the prices of WTI crude oil futures contracts may be near zero, zero or negative, which can occur rapidly and unexpectedly.  For example, in April 2020, a collapse of demand for fuel contributed to an oversupply of crude oil that rapidly filled most available oil storage facilities.  Storage shortages meant that market participants that had contracted to buy and take delivery of crude oil were at risk of default under the terms of the May 2020 NYMEX WTI crude oil futures contract.  The scarcity of storage resulted in some market participants selling their futures contracts at a negative price (effectively paying another market participant to accept delivery of the crude oil referenced by the relevant contracts).  As a result, for the first time in history, crude oil futures contracts traded below zero.  On April 20, 2020, the last trading day before expiration of the May 2020 WTI crude oil futures contract, prices of that contract fell to negative $37.63. See “Basket Overview.”

Brent crude oil. Demand for refined petroleum products by consumers, as well as by the agricultural, manufacturing and transportation industries, affects the price of crude oil.  Crude oil’s end-use as a refined product is often as transport fuel, industrial fuel and in-home heating fuel.  Potential for substitution in most areas exists, although considerations including relative cost often limit substitution levels.  Because the precursors of demand for petroleum products are linked to economic activity, demand will tend to reflect economic conditions.  Demand is also influenced by government regulations, such as environmental or consumption policies.  In addition to general economic activity and demand, prices for crude oil are affected by political events, labor activity, developments in production technology such as fracking and, in particular, direct government intervention (such as embargos) or supply disruptions in major oil producing regions of the world.  Such events tend to affect oil prices worldwide, regardless of the location of the event.  Supply for crude oil may increase or decrease depending on many factors.  These include production decisions by the Organization of the Petroleum Exporting Countries and other crude oil producers.  In the event of sudden disruptions in the supplies of oil, such as those caused by war, natural events, accidents, acts of terrorism or cyberattacks, prices of oil futures contracts could become extremely volatile and unpredictable.  Also, sudden and dramatic changes in the futures market may occur, for example, upon a cessation of hostilities that may exist in countries producing oil, the introduction of new or previously withheld supplies into the market or the introduction of substitute products or commodities.  The price of Brent crude oil futures has experienced very severe price fluctuations over the recent past and there can be no assurance that this extreme price volatility will not continue in the future. See “Basket Overview.”

Natural gas. Natural gas is used primarily for residential and commercial heating and in the production of electricity. Natural gas has also become an increasingly popular source of energy in the United States, both for consumers and industry. However, because natural gas can be used as a substitute for coal and oil in certain circumstances, the price of coal and oil influence the price of natural gas. The level of global industrial activity influences the demand for natural gas. The demand for natural gas has traditionally been cyclical, with higher demand during the winter months and lower demand during relatively warmer summer months. Seasonal temperatures in countries throughout the world can also heavily influence the demand for natural gas. The world’s supply of natural gas is concentrated in the former Soviet Union, the Middle East, Europe and Africa. In general, the supply of natural gas is based on competitive market forces. Inadequate supply at any one time leads to price increases, which signal to production companies the need to increase the supply of natural gas to the market. The ability of production companies to supply natural gas, however, is dependent on a number of factors. Factors that affect the short term supply of natural gas include the availability of skilled workers and equipment, permitting and well development, as well as weather and delivery disruptions (e.g., hurricanes, labor strikes and wars). In addition, production companies face more general barriers to their ability to increase the supply of natural gas, including access to land, the expansion of pipelines and the financial environment. These factors, which are not exhaustive, are interrelated and can have complex and unpredictable effects on the supply for, and the price of, natural gas.

Corn. The demand for corn is in part linked to the development of industrial and energy uses for corn. This includes the use of corn in the production of ethanol. The demand for corn is also affected by the production and profitability of the pork and poultry sectors, which use corn for feed. Negative developments in those industries may lessen the demand for corn. For example, if avian flu were to have a negative effect on world poultry markets, the demand for corn might decrease. The supply of corn is dependent on many factors including weather patterns, government regulation, the price of fuel and fertilizers and the current and previous price of corn. The United States is the world’s largest supplier of corn, followed by China and Brazil. The supply of corn is particularly

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sensitive to weather patterns in the United States and China. In addition, technological advances could lead to increases in worldwide production of corn and corresponding decreases in the price of corn.

Soybeans. Demand for soybeans is in part linked to the development of agricultural, industrial and energy uses for soybeans. In addition, prices for soybeans are affected by governmental programs and policies regarding agriculture and trade specifically, and trade, fiscal and monetary issues, more generally. Soybean prices are also affected by extrinsic factors such as weather, crop yields, natural disasters, pestilence, technological developments, wars and political and civil upheavals. Soy biodiesel, animal agriculture, vegetable oil, edible soybean oil and new industrial uses are examples of major areas that may impact worldwide soybean demand. In addition, substitution of other commodities for soybeans could also impact the price of soybeans. The supply of soybeans is particularly sensitive to weather patterns such as floods, drought and freezing conditions, planting decisions and the price of fuel, seeds and fertilizers. In addition, technological advances and scientific developments could lead to increases in worldwide production of soybeans and corresponding decreases in the price of soybeans. The United States, Argentina and Brazil are the three largest suppliers of soybean crops.

Wheat. Wheat prices are primarily affected by weather and crop growing conditions generally and the global demand for and supply of grain, which are driven by global grain production, population growth and economic activity. Demand for wheat is in part linked to the development of agricultural, industrial and energy uses for wheat including the use of wheat for the production of animal feed and bioethanol, which may have a major impact on worldwide demand for wheat. In addition, prices for wheat are affected by governmental and intergovernmental programs and policies regarding trade, agriculture, and energy and, more generally, regarding fiscal and monetary issues. Wheat prices may also be influenced by or dependent on retail prices, social trends, lifestyle changes and market power. Substitution of other commodities for wheat could also impact the price of wheat. The supply of wheat is particularly sensitive to weather patterns such as floods, drought and freezing conditions, planting decisions, the price of fuel, seeds and fertilizers and the current and previous price of wheat. In addition, technological advances and scientific developments could lead to increases in worldwide production of wheat and corresponding decreases in the price of wheat. Extrinsic factors affecting wheat prices include natural disasters, pestilence, wars and political and civil upheavals. China, India and the United States are the three largest suppliers of wheat crops.

Copper.  Demand for copper is significantly influenced by the level of global industrial economic activity.  Industrial sectors which are particularly important to demand for copper include the electrical and construction sectors.  In recent years demand has been supported by strong consumption from newly industrializing countries due to their copper-intensive economic growth and infrastructure development.  An additional, but highly volatile, component of demand is adjustments to inventory in response to changes in economic activity and/or pricing levels.  There are substitutes for copper in various applications.  Their availability and price will also affect demand for copper.  The main sources of copper are mines in Latin America and Eastern Europe and copper is refined mainly in Latin America, Australia and Asia.  The supply of copper is also affected by current and previous price levels, which will influence investment decisions in new smelters.  In previous years, copper supply has been affected by strikes, financial problems and terrorist activity.  It is not possible to predict the aggregate effect of all or any combination of these factors.  See “Basket Overview.”

Zinc. Demand for zinc is significantly influenced by the level of global industrial economic activity. The galvanized steel industrial sector is particularly important to demand for zinc given that the use of zinc in the manufacture of galvanized steel accounts for a significant percentage of worldwide zinc demand. The galvanized steel sector is in turn heavily dependent on the automobile and construction sectors. Growth in the production of galvanized steel will drive zinc demand. An additional, but highly volatile, component of demand is adjustments to inventory in response to changes in economic activity and/or pricing levels. The supply of zinc concentrate (the raw material) is dominated by Australia, North America and Latin America. The supply of zinc is also affected by current and previous price levels, which will influence investment decisions in new mines and smelters.

Additionally, recently, prior to and since Russia’s further invasion of Ukraine, the prices of oil and wheat, including the prices of WTI crude oil futures contracts, Brent crude oil futures contracts and wheat futures contracts, have been volatile and increased significantly. This conflict has led to disruptions in the supply of oil and the supply of wheat and caused fluctuations in the price of oil and the price of wheat, and changing geopolitical conditions and political events in Europe, the Middle East and elsewhere are likely to cause continued volatility in the price of oil and the price of wheat. In addition, on March 8, 2022, the U.S. Government issued an executive order banning the

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import of Russian oil to the United States. The U.S. Congress has also passed legislation to ban imports of Russian oil. These actions, and similar governmental, regulatory or legislative actions in the United States or in other jurisdictions, including, without limitation, sanctions-related actions by the U.S. or foreign governments, could cause prices of oil futures contracts and wheat futures contracts to become even more volatile and unpredictable. Any of these developments could adversely affect the price of WTI crude oil futures, Brent crude oil futures and wheat futures, and, therefore, the value of the notes and the payment at maturity.

§ Suspensions or disruptions of market trading in commodity and related futures markets may adversely affect the price of the notes.  The commodity markets are subject to temporary distortions or other disruptions due to various factors, including the lack of liquidity in the markets, the participation of speculators and government regulation and intervention.  In addition, U.S. futures exchanges and some foreign exchanges have regulations that limit the amount of fluctuation in futures contract prices which may occur during a single business day.  These limits are generally referred to as “daily price fluctuation limits” and the maximum or minimum price of a contract on any given day as a result of these limits is referred to as a “limit price.”  Once the limit price has been reached in a particular contract, no trades may be made at a different price.  Limit prices have the effect of precluding trading in a particular contract or forcing the liquidation of contracts at disadvantageous times or prices.  These circumstances could adversely affect the prices of some of the basket commodities and, therefore, the value of the notes.

§ There are risks relating to the trading of metals on the London Metal Exchange.  The official cash offer price of copper is determined by reference to the per unit U.S. dollar cash offer prices of contracts traded on the London Metal Exchange, which we refer to as the LME.  The LME is a principals’ market which operates in a manner more closely analogous to the over-the-counter physical commodity markets than regulated futures markets.  For example, there are no daily price limits on the LME, which would otherwise restrict the extent of daily fluctuations in the prices of LME contracts.  In a declining market, therefore, it is possible that prices would continue to decline without limitation within a trading day or over a period of trading days.  In addition, a contract may be entered into on the LME calling for delivery on any day from one day to three months following the date of such contract and for monthly delivery in any of the next 16 to 24 months (depending on the commodity) following such third month, in contrast to trading on futures exchanges, which call for delivery in stated delivery months.  As a result, there may be a greater risk of a concentration of positions in LME contracts on particular delivery dates, which in turn could cause temporary aberrations in the prices of LME contracts for certain delivery dates.  If such aberrations occur on any determination date, the per unit U.S. dollar cash offer prices used to determine the official cash offer price of copper, and consequently, your payment at maturity, if any, could be adversely affected.

§ An investment linked to commodity futures contracts is not equivalent to an investment linked to the spot prices of physical commodities.  The notes have returns based on the change in price of futures contracts on WTI crude oil, Brent crude oil, natural gas, corn, soybeans and wheat, not the change in the spot price of actual physical commodities to which such futures contracts relate.  The price of a futures contract reflects the expected value of the commodity upon delivery in the future, whereas the price of a physical commodity reflects the value of such commodity upon immediate delivery, which is referred to as the spot price.  Several factors can result in differences between the price of a commodity futures contract and the spot price of a commodity, including the cost of storing such commodity for the length of the futures contract, interest costs related to financing the purchase of such commodity and expectations of supply and demand for such commodity.  While the changes in the price of a futures contract are usually correlated with the changes in the spot price, such correlation is not exact.  In some cases, the performance of a commodity futures contract can deviate significantly from the spot price performance of the related underlying commodity, especially over longer periods of time.  Accordingly, investments linked to the return of commodities futures contracts may underperform similar investments that reflect the spot price return on physical commodities.

§ Differences between futures prices and the spot prices of the physical commodities which, in part, compose the basket may decrease the amount payable at maturity.  The commodity prices that are used to determine the initial basket commodity prices and the final basket commodity prices for the physical commodities which, in part, compose the basket and, therefore, the payment at maturity on the notes are determined by reference to the settlement prices of the first nearby month futures contract for each such commodity on the pricing date and determination date, respectively, provided that if such date falls on the last trading day of such futures contract, then the second nearby month futures contract on such date, and will not therefore reflect the spot prices of such physical commodities on such dates. The market for futures contracts on the basket commodities has experienced periods of backwardation, in which futures prices are lower than the spot price, and periods of contango, in which futures prices

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are higher than the spot price.  If the contract for any basket commodity is in contango on the pricing date or in backwardation on the determination date, the payment at maturity payable, if any, on the maturity date, may be less than if the initial commodity price or the final commodity price for such basket commodity, respectively, were determined with reference to the spot price.

§ Legal and regulatory changes could adversely affect the return on and value of the notes.  Futures contracts and options on futures contracts, including those related to the basket commodities, are subject to extensive statutes, regulations, and margin requirements.  The Commodity Futures Trading Commission, commonly referred to as the “CFTC,” and the exchanges on which such futures contracts trade, are authorized to take extraordinary actions in the event of a market emergency, including, for example, the retroactive implementation of speculative position limits or higher margin requirements, the establishment of daily limits and the suspension of trading.  Furthermore, certain exchanges have regulations that limit the amount of fluctuations in futures contract prices that may occur during a single five-minute trading period.  These limits could adversely affect the market prices of relevant futures and options contracts and forward contracts.  The regulation of commodity transactions in the U.S. is subject to ongoing modification by government and judicial action.  In addition, various non-U.S. governments have expressed concern regarding the disruptive effects of speculative trading in the commodity markets and the need to regulate the derivative markets in general.  The effect on the value of the notes of any future regulatory change is impossible to predict, but could be substantial and adverse to the interests of holders of the notes.

For example, the Dodd-Frank Act, which was enacted on July 21, 2010, requires the CFTC to establish limits on the amount of positions that may be held by any person in certain commodity futures contracts and swaps, futures and options that are economically equivalent to such contracts.  While the effects of these or other regulatory developments are difficult to predict, when adopted, such rules may have the effect of making the markets for commodities, commodity futures contracts, options on futures contracts and other related derivatives more volatile and over time potentially less liquid.  Such restrictions may force market participants, including us and our affiliates, or such market participants may decide, to sell their positions in such futures contracts and other instruments subject to the limits.  If this broad market selling were to occur, it would likely lead to declines, possibly significant declines, in commodity prices, in the price of such commodity futures contracts or instruments and potentially, the value of the notes.

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Basket Overview

The basket is an equally-weighted basket composed of eight commodities.

Basket commodity information as of June 10, 2022
Basket Commodity	Bloomberg Ticker Symbol*	Current Price	52 Weeks Ago	52 Week High	52 Week Low	Weighting
WTI crude oil	CL1	$120.67	$70.29	$123.70 (on 3/8/2022)	$62.32 (on 8/20/2021)	12.50%
Brent crude oil	CO1	$122.01	$72.52	$127.98 (on 3/8/2022)	$65.18 (on 8/20/2021)	12.50%
Natural gas	NG1	$8.8500	$3.1490	$9.3220 (on 6/6/2022)	$3.1490 (on 6/10/2021)	12.50%
Corn	C 1	773.25¢	699.00¢	818.25¢ (on 4/29/2022)	495.75¢ (on 9/7/2021)	12.50%
Soybeans	S 1	1,745.50¢	1,544.00¢	1,769.00¢ (on 6/9/2022)	1,178.00¢ (on 11/8/2021)	12.50%
Wheat	W 1	1,070.75¢	683.75¢	1,425.25¢ (on 3/7/2022)	608.50¢ (on 7/9/2021)	12.50%
Copper	LOCADY	$9,537.00	$9,808.50	$10,730.00 (on 3/7/2022)	$8,775.50 (on 8/19/2021)	12.50%
Zinc	LOZSDY	$3,755.00	$2,965.50	$4,530.00 (on 4/19/2022)	$2,832.00 (on 6/21/2021)	12.50%

* Bloomberg ticker symbols are being provided for reference purposes only.  The initial basket commodity price and the final basket commodity price for each basket commodity will be determined based on the values published by the relevant exchange and, notwithstanding the Bloomberg ticker symbols provided for reference purposes above, such prices (in the case of WTI crude oil, Brent crude oil, natural gas, corn, soybeans and wheat) may be based on the second nearby month futures contract, as further described under “Commodity price” on page 2.

The following graph is calculated to show the performance of the basket during the period from January 1, 2017 through June 10, 2022, assuming the basket commodities are weighted as set out above, and illustrates the effect of the offset and/or correlation among the basket commodities during such period.  The graph does not attempt to show your expected return on an investment in the notes.  You cannot predict the future performance of any basket commodity or of the basket as a whole, or whether increases in the price of any basket commodity will be offset by decreases in the prices of the other basket commodities.  The historical performance of the basket and the degree of correlation between the price trends of the basket commodities (or lack thereof) should not be taken as an indication of its future performance.

Historical Basket Performance 

January 1, 2017 through June 10, 2022

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Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

The following graphs set forth the daily prices for each of the basket commodities for each quarter in the period from January 1, 2017 through June 10, 2022.  The related tables set forth the published high and low, as well as end-of-quarter, prices for each respective basket commodity for the same period.  The commodity prices on June 10, 2022 were, in the case of WTI crude oil, $120.67, in the case of Brent crude oil, $122.01, in the case of Natural gas, $8.8500, in the case of Corn – CBOT, 773.25¢, in the case of Soybeans – CBOT 1,745.50¢, in the case of Wheat – CBOT, 1,070.75¢, in the case of copper, $9,537.00 and in the case of Zinc, $3,755.00.  We obtained the information in the graphs and tables from Bloomberg Financial Markets, without independent verification.  The historical prices and historical performance of the basket commodities should not be taken as an indication of future performance.  

Daily Prices of WTI Crude OilJanuary 1, 2017 to June 10, 2022

WTI Crude Oil (in U.S. dollars)	High ($)	Low($)	Period End ($)
2017
First Quarter	54.45	47.34	50.60
Second Quarter	53.40	42.53	46.04
Third Quarter	52.22	44.23	51.67
Fourth Quarter	60.42	49.29	60.42
2018
First Quarter	66.14	59.19	64.94
Second Quarter	74.15	62.06	74.15
Third Quarter	74.14	65.01	73.25
Fourth Quarter	76.41	42.53	45.41
2019
First Quarter	60.14	46.54	60.14
Second Quarter	66.30	51.14	58.47
Third Quarter	62.90	51.09	54.07
Fourth Quarter	61.72	52.45	61.06
2020
First Quarter	63.27	20.09	20.48
Second Quarter	40.46	-37.63	39.27
Third Quarter	43.39	36.76	40.22
Fourth Quarter	49.10	35.79	48.52
2021
First Quarter	66.09	47.62	59.16
Second Quarter	74.05	58.65	73.47
Third Quarter	75.45	62.32	75.03
Fourth Quarter	84.65	65.57	75.21
2022
First Quarter	123.70	76.08	100.28
Second Quarter (through June 10, 2022)	122.11	94.29	120.67

The prices of WTI crude oil futures contracts may be near zero, zero or negative, which can occur rapidly and unexpectedly.  In April 2020, crude oil futures contracts traded below zero.  See “Risk Factors—Specific commodities’ prices are volatile and are affected by numerous factors specific to each market—WTI crude oil.”

June 2022 Page 18

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Daily Prices of Brent Crude Oil
January 1, 2017 to June 10, 2022

Brent Crude Oil (in U.S. dollars)	High ($)	Low ($)	Period End ($)
2017
First Quarter	57.10	50.56	52.83
Second Quarter	56.23	44.82	47.92
Third Quarter	59.02	46.71	57.54
Fourth Quarter	67.02	55.62	66.87
2018
First Quarter	70.53	62.59	70.27
Second Quarter	79.80	67.11	79.44
Third Quarter	82.72	70.76	82.72
Fourth Quarter	86.29	50.47	53.80
2019
First Quarter	68.50	54.91	68.39
Second Quarter	74.57	59.97	66.55
Third Quarter	69.02	56.23	60.78
Fourth Quarter	68.44	57.69	66.00
2020
First Quarter	68.91	22.74	22.74
Second Quarter	43.08	19.33	41.15
Third Quarter	45.86	39.61	40.95
Fourth Quarter	52.26	37.46	51.80
2021
First Quarter	69.63	51.09	63.54
Second Quarter	76.18	62.15	75.13
Third Quarter	79.53	65.18	78.52
Fourth Quarter	86.40	68.87	77.78
2022
First Quarter	127.98	78.98	107.91
Second Quarter (through June 10, 2022)	123.58	98.48	122.01

June 2022 Page 19

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Daily Prices of Natural Gas
January 1, 2017 to June 10, 2022

Natural Gas (in U.S. dollars)	High ($)	Low ($)	Period End ($)
2017
First Quarter	3.4190	2.5640	3.1900
Second Quarter	3.4240	2.8930	3.0350
Third Quarter	3.1460	2.7740	3.0070
Fourth Quarter	3.2130	2.5980	2.9530
2018
First Quarter	3.6310	2.5520	2.7330
Second Quarter	3.0220	2.6560	2.9240
Third Quarter	3.0820	2.7210	3.0080
Fourth Quarter	4.8370	2.9400	2.9400
2019
First Quarter	3.5910	2.5510	2.6620
Second Quarter	2.7080	2.1850	2.3080
Third Quarter	2.6810	2.0700	2.3300
Fourth Quarter	2.8620	2.1580	2.1890
2020
First Quarter	2.2020	1.6020	1.6400
Second Quarter	2.1340	1.4820	1.7510
Third Quarter	2.6570	1.6410	2.5270
Fourth Quarter	3.3540	2.3050	2.5390
2021
First Quarter	3.2190	2.4460	2.6080
Second Quarter	3.6500	2.4560	3.6500
Third Quarter	5.8670	3.5960	5.8670
Fourth Quarter	6.3120	3.5610	3.7300
2022
First Quarter	6.2650	3.7170	5.6420
Second Quarter (through June 10, 2022)	9.3220	5.7120	8.8500

June 2022 Page 20

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Daily Prices of Corn
January 1, 2017 to June 10, 2022

Corn (in U.S. cents)	High (¢)	Low (¢)	Period End (¢)
2017
First Quarter	378.75	353.75	364.25
Second Quarter	387.75	356.75	370.50
Third Quarter	392.25	329.50	355.25
Fourth Quarter	353.75	335.75	350.75
2018
First Quarter	387.75	346.25	387.75
Second Quarter	408.50	345.00	350.25
Third Quarter	372.25	330.25	356.25
Fourth Quarter	385.50	356.00	375.00
2019
First Quarter	383.00	352.50	356.50
Second Quarter	454.75	342.50	420.25
Third Quarter	449.50	340.75	388.00
Fourth Quarter	397.75	357.75	387.75
2020
First Quarter	393.75	335.25	340.75
Second Quarter	338.50	302.75	338.50
Third Quarter	379.00	307.75	379.00
Fourth Quarter	484.00	379.50	484.00
2021
First Quarter	565.00	483.75	564.25
Second Quarter	772.75	553.25	720.00
Third Quarter	719.75	495.75	536.75
Fourth Quarter	614.75	512.25	593.25
2022
First Quarter	764.50	587.50	748.75
Second Quarter (through June 10, 2022)	818.25	727.00	773.25

June 2022 Page 21

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Daily Prices of Soybeans
January 1, 2017 to June 10, 2022

Soybeans (in U.S. cents)	High (¢)	Low (¢)	Period End (¢)
2017
First Quarter	1,075.00	946.00	946.00
Second Quarter	976.25	904.00	942.25
Third Quarter	1,025.25	921.75	968.25
Fourth Quarter	1,008.50	945.75	951.75
2018
First Quarter	1,066.75	940.50	1,044.75
Second Quarter	1,060.75	858.50	858.50
Third Quarter	903.75	814.00	845.50
Fourth Quarter	920.00	833.50	882.50
2019
First Quarter	925.25	877.75	884.25
Second Quarter	915.50	791.00	899.75
Third Quarter	906.75	843.25	906.00
Fourth Quarter	943.00	870.50	943.00
2020
First Quarter	944.25	821.75	886.00
Second Quarter	884.25	826.00	884.25
Third Quarter	1,043.50	870.25	1,023.50
Fourth Quarter	1,315.25	1,020.75	1,315.25
2021
First Quarter	1,441.25	1,311.75	1,436.75
Second Quarter	1,660.50	1,329.75	1,450.00
Third Quarter	1,467.75	1,256.00	1,256.00
Fourth Quarter	1,362.50	1,178.00	1,328.75
2022
First Quarter	1,718.75	1,344.00	1,618.25
Second Quarter (through June 10, 2022)	1,769.00	1,582.75	1,745.50

June 2022 Page 22

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Daily Prices of Wheat
January 1, 2017 to June 10, 2022

Wheat (in U.S. cents)	High (¢)	Low (¢)	Period End (¢)
2017
First Quarter	454.75	406.50	426.50
Second Quarter	511.00	402.50	511.00
Third Quarter	539.25	400.00	448.25
Fourth Quarter	448.00	387.25	427.00
2018
First Quarter	505.50	416.50	451.00
Second Quarter	543.00	446.25	497.50
Third Quarter	574.50	469.75	509.00
Fourth Quarter	535.25	487.25	503.25
2019
First Quarter	527.25	422.25	457.75
Second Quarter	547.50	418.50	528.00
Third Quarter	536.25	447.25	495.75
Fourth Quarter	558.75	488.75	558.75
2020
First Quarter	581.50	498.00	568.75
Second Quarter	556.50	474.00	490.00
Third Quarter	578.00	489.50	578.00
Fourth Quarter	640.75	563.75	640.50
2021
First Quarter	680.25	601.75	618.00
Second Quarter	773.50	611.00	671.50
Third Quarter	762.25	608.50	725.50
Fourth Quarter	856.00	718.75	770.75
2022
First Quarter	1,425.25	741.50	1,006.00
Second Quarter (through June 10, 2022)	1,277.50	984.50	1,070.75

June 2022 Page 23

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Daily Prices of Copper
January 1, 2017 to June 10, 2022

Copper (in U.S. dollars)	High ($)	Low ($)	Period End ($)
2017
First Quarter	6,145.00	5,500.50	5,849.00
Second Quarter	5,907.50	5,466.00	5,907.50
Third Quarter	6,904.00	5,780.00	6,485.00
Fourth Quarter	7,216.00	6,447.00	7,157.00
2018
First Quarter	7,202.50	6,500.00	6,685.00
Second Quarter	7,262.50	6,625.00	6,646.00
Third Quarter	6,595.00	5,823.00	6,180.00
Fourth Quarter	6,325.00	5,931.50	5,965.00
2019
First Quarter	6,572.00	5,811.00	6,485.00
Second Quarter	6,509.00	5,756.00	5,972.00
Third Quarter	6,066.00	5,537.00	5,728.00
Fourth Quarter	6,211.00	5,599.00	6,156.00
2020
First Quarter	6,300.50	4,617.50	4,797.00
Second Quarter	6,038.00	4,772.00	6,038.00
Third Quarter	6,837.00	6,016.50	6,610.00
Fourth Quarter	7,964.00	6,409.50	7,741.50
2021
First Quarter	9,614.50	7,755.50	8,850.50
Second Quarter	773.50	611.00	671.50
Third Quarter	9,781.00	8,775.50	9,041.00
Fourth Quarter	10,652.00	9,091.50	9,692.00
2022
First Quarter	10,730.00	9,565.00	10,337.00
Second Quarter (through June 10, 2022)	10,426.00	9,018.50	9,537.00

June 2022 Page 24

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Daily Prices of Zinc
January 1, 2017 to June 10, 2022

Zinc (in U.S. dollars)	High ($)	Low ($)	Period End ($)
2017
First Quarter	2,971.00	2,530.00	2,782.50
Second Quarter	2,777.00	2,434.50	2,754.00
Third Quarter	3,217.00	2,737.00	3,217.00
Fourth Quarter	3,370.00	3,094.00	3,309.00
2018
First Quarter	3,618.00	3,215.00	3,332.00
Second Quarter	3,284.50	2,895.00	2,948.00
Third Quarter	2,915.00	2,287.00	2,573.00
Fourth Quarter	2,740.00	2,506.00	2,510.50
2019
First Quarter	3,000.00	2,462.00	3,000.00
Second Quarter	3,018.00	2,518.00	2,580.50
Third Quarter	2,546.00	2,211.00	2,377.00
Fourth Quarter	2,595.00	2,221.50	2,293.00
2020
First Quarter	2,466.50	1,773.50	1,867.50
Second Quarter	2,073.00	1,843.00	2,056.50
Third Quarter	2,554.00	2,007.50	2,413.00
Fourth Quarter	2,841.50	2,298.00	2,723.50
2021
First Quarter	2,894.50	2,539.00	2,795.00
Second Quarter	3,063.50	2,754.50	2,945.50
Third Quarter	3,110.00	2,912.00	3,015.00
Fourth Quarter	3,815.00	2,999.00	3,630.00
2022
First Quarter	4,260.00	3,535.00	4,260.00
Second Quarter (through June 10, 2022)	4,530.00	3,500.00	3,755.00

June 2022 Page 25

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Additional Terms of the Notes

Please read this information in conjunction with the summary terms on the front cover of this document.

Additional Terms:
If the terms described herein are inconsistent with those described in the accompanying prospectus supplement or prospectus, the terms described herein shall control.
Postponement of maturity date:	If, due to a market disruption event or otherwise, the date for determining the final basket commodity price of any basket commodity is postponed so that it falls less than two business days prior to the scheduled maturity date, the maturity date will be postponed to the second business day following the final date by which the final basket commodity price for all basket commodities has been determined.
Denominations:	$1,000 per note and integral multiples thereof
Interest:	None
Trustee:	The Bank of New York Mellon
Calculation agent:	Morgan Stanley Capital Group Inc. (“MSCG”) and its successors
Issuer notice to registered security holders, the trustee and the depositary:	In the event that the maturity date is postponed due to a market disruption event with respect to any basket commodity on the scheduled determination date or otherwise, the issuer shall give notice of such postponement and, once it has been determined, of the date to which the maturity date has been rescheduled (i) to each registered holder of the notes by mailing notice of such postponement by first class mail, postage prepaid, to such registered holder’s last address as it shall appear upon the registry books, (ii) to the trustee by facsimile confirmed by mailing such notice to the trustee by first class mail, postage prepaid, at its New York office and (iii) to The Depository Trust Company (the “depositary”) by telephone or facsimile, confirmed by mailing such notice to the depositary by first class mail, postage prepaid.  Any notice that is mailed to a registered holder of the notes in the manner herein provided shall be conclusively presumed to have been duly given to such registered holder, whether or not such registered holder receives the notice.  The issuer shall give such notice as promptly as possible, and in no case later than (i) with respect to notice of postponement of the maturity date, the business day immediately preceding the scheduled maturity date, and (ii) with respect to notice of the date to which the maturity date has been rescheduled, the business day immediately following the actual date by which the final basket commodity price for each basket commodity has been determined. The issuer shall, or shall cause the calculation agent to, (i) provide written notice to the trustee, on which notice the trustee may conclusively rely, and to the depositary of the amount of cash, if any, to be delivered with respect to the notes, on or prior to 10:30 a.m. (New York City time) on the business day preceding the maturity date, and (ii) deliver the aggregate cash amount due with respect to the notes, if any, to the trustee for delivery to the depositary, as holder of the notes, on the maturity date.

June 2022 Page 26

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

Additional Information About the Notes

Additional provisions:
Minimum ticketing size:	$1,000 / 1 note
Tax considerations:	In the opinion of our counsel, Davis Polk & Wardwell LLP, the notes should be treated as “contingent payment debt instruments” for U.S. federal income tax purposes, as described in the section of the accompanying prospectus supplement called “United States Federal Taxation—Tax Consequences to U.S. Holders.” Under this treatment, if you are a U.S. taxable investor, you generally will be subject to annual income tax based on the “comparable yield” (as defined in the accompanying prospectus supplement) of the notes, adjusted upward or downward to reflect the difference, if any, between the actual and projected amount of the payments on the notes.  The comparable yield will be determined on the pricing date and may be significantly higher or lower than the comparable yield if the notes were priced on the date hereof.  The comparable yield and the projected payment schedule (or information about how to obtain them) will be provided in the final pricing supplement.  In addition, any gain recognized by U.S. taxable investors on the sale or exchange, or at maturity, of the notes generally will be treated as ordinary income.     You should read the discussion under “United States Federal Taxation” in the accompanying prospectus supplement concerning the U.S. federal income tax consequences of an investment in the notes.   The comparable yield and the projected payment schedule will not be provided for any purpose other than the determination of U.S. Holders’ accruals of interest income and adjustments thereto in respect of the notes for U.S. federal income tax purposes, and we make no representation regarding the actual amount of the payments that will be made on the notes.   If you are a non-U.S. investor, please also read the section of the accompanying prospectus supplement called “United States Federal Taxation—Tax Consequences to Non-U.S. Holders.” In addition, Section 871(m) of the Internal Revenue Code of 1986, as amended (the “Code”), and Treasury regulations promulgated thereunder (“Section 871(m)”) generally impose a 30% (or a lower applicable treaty rate) withholding tax on dividend equivalents paid or deemed paid to Non-U.S. Holders with respect to certain financial instruments linked to U.S. equities or indices that include U.S. equities (each, an “Underlying Security”).  Because the notes reference a basket of commodities, and neither the basket nor any of the commodities is treated for U.S. federal income tax purposes as an Underlying Security, payment on the notes to Non-U.S. Holders should not be subject to Section 871(m). You should consult your tax adviser regarding all aspects of the U.S. federal income tax consequences of an investment in the notes, as well as any tax consequences arising under the laws of any state, local or non-U.S. taxing jurisdiction.   The discussion in the preceding paragraphs under “Tax considerations” and the discussion contained in the section entitled “United States Federal Taxation” in the accompanying prospectus supplement, insofar as they purport to describe provisions of U.S. federal income tax laws or legal conclusions with respect thereto, constitute the full opinion of Davis Polk & Wardwell LLP regarding the material U.S. federal tax consequences of an investment in the notes.
Use of proceeds and hedging:	The proceeds we receive from the sale of the notes will be used for general corporate purposes.  We will receive, in aggregate, $1,000 per note issued, because, when we enter into hedging transactions in order to meet our obligations under the notes, our hedging counterparty will reimburse the cost of the agent’s commissions.  The costs of the notes borne by you and described on page 3 above comprise the agent’s commissions and the cost of issuing, structuring and hedging the notes. On or prior to the pricing date, we will hedge our anticipated exposure in connection with the notes, by entering into hedging transactions with our subsidiaries and/or third-party dealers.  We expect our hedging counterparties to take positions in any of the basket commodities, in futures or options contracts on any of the basket commodities listed on major securities markets or positions in any other available securities or instruments that they may wish to use in connection with such hedging.  Such purchase activity could increase the initial basket commodity prices of the basket commodities and, therefore, could increase the price at or above which the basket commodities must close on the determination date before you would receive at maturity a payment that exceeds the stated principal amount of the notes.  Additionally, such hedging or trading activities during the term of the notes, including on the determination date, could potentially affect whether the basket performance is positive and, accordingly, the amount of cash you will receive at maturity.  For further information on our use of proceeds and hedging, see “Use of Proceeds and Hedging” in the accompanying prospectus supplement.
Additional considerations:	Client accounts over which Morgan Stanley, Morgan Stanley Wealth Management or any of their respective subsidiaries have investment discretion are not permitted to purchase the notes, either directly or indirectly.
Supplemental information	The agent may distribute the notes through Morgan Stanley Smith Barney LLC (“Morgan Stanley Wealth

June 2022 Page 27

Morgan Stanley Finance LLC

Commodity-Linked Notes due December 27, 2024 

Based on the Performance of a Basket Consisting of Eight Commodities

concerning plan of distribution; conflicts of interest:

Management”), as selected dealer, or other dealers, which may include Morgan Stanley & Co. International plc (“MSIP”) and Bank Morgan Stanley AG. Morgan Stanley Wealth Management, MSIP and Bank Morgan Stanley AG are affiliates of ours. Selected dealers, including Morgan Stanley Wealth Management, and their financial advisors will collectively receive from the agent, Morgan Stanley & Co. LLC, a fixed sales commission of $25 for each note they sell. In addition, Morgan Stanley Wealth Management will receive a structuring fee of $5 for each note. The costs included in the original issue price of the notes will include a fee paid by MS & Co. to LFT Securities, LLC, an entity in which an affiliate of Morgan Stanley Wealth Management has an ownership interest, for providing certain electronic platform services with respect to this offering. MS & Co. is an affiliate of MSFL and a wholly owned subsidiary of Morgan Stanley, and it and other affiliates of ours expect to make a profit by selling, structuring and, when applicable, hedging the notes. When MS & Co. prices this offering of notes, it will determine the economic terms of the notes such that for each security the estimated value on the pricing date will be no lower than the minimum level described in “Investment Summary” beginning on page 3. MS & Co. will conduct this offering in compliance with the requirements of FINRA Rule 5121 of the Financial Industry Regulatory Authority, Inc., which is commonly referred to as FINRA, regarding a FINRA member firm’s distribution of the notes of an affiliate and related conflicts of interest. MS & Co. or any of our other affiliates may not make sales in this offering to any discretionary account. See “Plan of Distribution (Conflicts of Interest)” and “Use of Proceeds and Hedging” in the accompanying prospectus supplement.

Where you can find more information:

Morgan Stanley and MSFL have filed a registration statement (including a prospectus, as supplemented by the prospectus supplement for commodity-linked notes) with the Securities and Exchange Commission, or SEC, for the offering to which this communication relates.  You should read the prospectus in that registration statement, the prospectus supplement for commodity-linked notes and any other documents relating to this offering that Morgan Stanley and MSFL have filed with the SEC for more complete information about Morgan Stanley, MSFL and this offering.  You may get these documents without cost by visiting EDGAR on the SEC web site at www.sec.gov.  Alternatively, Morgan Stanley, MSFL, any underwriter or any dealer participating in this offering will arrange to send you the prospectus supplement for commodity-linked notes and prospectus if you so request by calling toll-free 800-584-6837. You may access these documents on the SEC web site at www.sec.gov as follows: Prospectus Supplement for Commodity-Linked Notes dated November 16, 2020 Prospectus dated November 16, 2020

June 2022 Page 28