ENTREMED, INC.
9460 MEDICAL CENTER DRIVE
ROCKVILLE, MD 20850

September 17, 2007

VIA EDGAR

Mark Brunhofer
Senior Staff Accountant
Securities and Exchange Commission
100 F Street, N.E.
Washington, D.C. 20549

Re:	EntreMed, Inc.
	Form 10-K for Fiscal Year Ended December 31, 2006
	File No. 0-20713

Dear Mr. Brunhofer:

      Pursuant to our telephone call on September 14, 2007, this letter confirms that EntreMed, Inc. has requested an extension of twenty business days to respond to the Staff's comment letter dated August 31, 2007, until October 15, 2007.

      If you have any questions, please contact me at (240) 864-2651.

Sincerely,

/s/ Dane R. Saglio

Dane R. Saglio
Chief Financial Officer

Cc:    Jim B. Rosenberg