Exhibit 32.1


                                  CERTIFICATION


In connection with the Quarterly Report on Form 10-QSB of Integrated Surgical
Systems, Inc. (the "Company") for the period ended September 30, 2006, as filed
with the Securities and Exchange Commission on the date hereof (the "Report"),
I, Ramesh C. Trivedi, Chief Executive Officer of the Company, certify, pursuant
to 18 U.S.C. 1350, that:

     (1)  The Report fully complies with the requirements of Section 13(a) or
          15(d) of the Securities Exchange Act of 1934; and

     (2)  The information contained in the Report fairly presents, in all
          material respects, the financial condition and results of operations
          of the Company.


/s/ Ramesh C. Trivedi
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Ramesh C. Trivedi, Chief Executive Officer

April 13, 2007