Exhibit 32.1


                                  CERTIFICATION


In connection with the Quarterly Report on Form 10-QSB of Integrated Surgical
Systems, Inc. (the "Company") for the period ended June 30, 2006, as filed with
the Securities and Exchange Commission on the date hereof (the "Report"), I,
Ramesh C. Trivedi, Chief Executive Officer of the Company, certify, pursuant to
18 U.S.C. 1350, that:

     (1)  The Report fully complies with the requirements of Section 13(a) or
          15(d) of the Securities Exchange Act of 1934; and

     (2)  The information contained in the Report fairly presents, in all
          material respects, the financial condition and results of operations
          of the Company.


/s/ Ramesh C. Trivedi
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Ramesh C. Trivedi, Chief Executive Officer

April 13, 2007