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Non-controlling Interest and Related Party (Details) - USD ($)
3 Months Ended 6 Months Ended 9 Months Ended 12 Months Ended
Sep. 05, 2018
Sep. 30, 2022
Jun. 30, 2022
Jun. 30, 2022
Sep. 30, 2022
Dec. 31, 2022
Dec. 31, 2021
Noncontrolling Interest              
Net loss attributable to non-controlling interest           $ 0 $ (1,000)
Research and development expense   $ 2,570,000 $ 3,485,000 $ 6,082,000 $ 8,652,000 11,723,000 7,800,000
Stock Purchase Agreement              
Noncontrolling Interest              
Research and development expense           $ 0 $ 1,000
SYN Biomics              
Noncontrolling Interest              
Ownership percentage           100.00%  
SYN Biomics | SYN Biomics              
Noncontrolling Interest              
Ownership percentage 88.50%           100.00%
Cedars-Sinai Medical Center              
Noncontrolling Interest              
Expenses from transactions with related party $ 328,000            
Fair value of shares issued $ 285,000            
Cedars-Sinai Medical Center | Stock Purchase Agreement              
Noncontrolling Interest              
Number of common stock, shares to be issued 50,000            
Cedars-Sinai Medical Center | SYN Biomics | Stock Purchase Agreement              
Noncontrolling Interest              
Additional number of common stock, shares to be issued 2,420,000            
Number of common stock, shares to be held by related party 7,480,000            
Noncontrolling interest, ownership percentage by noncontrolling owners 17.00%