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Stock-Based Compensation and Warrants - Summary of stock option activity (Details) - USD ($)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Stock-Based Compensation and Warrants      
Options, Exercised 0    
Stock Option      
Stock-Based Compensation and Warrants      
Options, Beginning balance 625,565 399,779  
Options, Granted 1,728,000 226,000  
Options, Expired (43,126) (214)  
Options, Forfeited (14,541)    
Options, Ending balance 2,295,898 625,565 399,779
Options, Exercisable 429,736    
Weighted Average Exercise Price, Beginning balance $ 16.12 $ 23.50  
Weighted Average Exercise Price, Granted 0.58 3.30  
Weighted Average Exercise Price, Expired 67.81 431.50  
Weighted Average Exercise Price, Forfeited 3.61    
Weighted Average Exercise Price, Ending balance 3.53 $ 16.12 $ 23.50
Weighted Average Exercise Price, Exercisable $ 15.40    
Weighted Average Remaining Contractual Life, Outstanding 6 years 5 months 8 days 5 years 6 months 29 days 6 years 1 month 2 days
Weighted Average Remaining Contractual Life, Exercisable 4 years 6 months 25 days    
Aggregate Intrinsic Value, Beginning Balance $ 0    
Aggregate Intrinsic Value, Ending Balance 0 $ 0  
Aggregate Intrinsic Value, Exercisable 0    
Grant date fair value of options granted $ 706,264 $ 50,100  
Weighted average grant date fair value $ 0.41 $ 2.20