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Stock-Based Compensation and Warrants - Stock incentive plan and other information (Details) - USD ($)
12 Months Ended
Sep. 05, 2019
Nov. 02, 2010
Dec. 31, 2022
Dec. 31, 2021
Sep. 17, 2020
Mar. 20, 2007
Stock-Based Compensation and Warrants            
Unrecognized stock-based compensation expense     $ 997,000      
Proceeds from Stock Options Exercised     0 $ 0    
General and Administrative Expenses and Research and Development Expense | Employees            
Stock-Based Compensation and Warrants            
Allocated share-based compensation expense     $ 260,000 $ 204,000    
Employees And Directors            
Stock-Based Compensation and Warrants            
Share-based payment award, options, grants in period, gross     1,728,000 2,260,000    
Consultant | General and Administrative Expenses and Research and Development Expense            
Stock-Based Compensation and Warrants            
Allocated share-based compensation expense     $ 215,000 $ 212,000    
Employees | General and Administrative Expenses and Research and Development Expense            
Stock-Based Compensation and Warrants            
Allocated share-based compensation expense     $ 700,000 $ 500,000    
2007 Stock Plan            
Stock-Based Compensation and Warrants            
Share-based payment award, options, outstanding, number     515     7,143
2010 Stock Plan            
Stock-Based Compensation and Warrants            
Share-based payment award, options, outstanding, number   8,572        
Share-based compensation arrangement by share-based payment award, number of shares authorized 400,000          
Share-based compensation arrangement by share-based payment award, shares issued     0      
2010 Stock Plan | Board of Directors            
Stock-Based Compensation and Warrants            
Share-based payment award, options, outstanding, number     202,381      
2010 Stock Plan | Minimum            
Stock-Based Compensation and Warrants            
Share-based payment award, options, grants, expired period   5 years        
2010 Stock Plan | Maximum            
Stock-Based Compensation and Warrants            
Share-based payment award, options, grants, expired period   10 years        
2020 Stock Plan            
Stock-Based Compensation and Warrants            
Share-based payment award, options, outstanding, number     2,093,002   400,000  
Share-based compensation arrangement by share-based payment award, number of shares authorized     7,000,000