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License, Collaborative and Employment Agreements and Commitments - Maturity analysis of operating leases (Details) - USD ($)
$ in Thousands
Dec. 31, 2021
Dec. 31, 2020
Commitments and Contingencies    
2022 $ 247  
2023 327  
2024 337  
2025 347  
2026 357  
2027 368  
Total 1,983  
Discount factor (456)  
Lease liability 1,527  
Lease liability - current (124) $ (287)
Lease liability - long term $ 1,403 $ 186
Operating Lease, Liability, Statement of Financial Position [Extensible List] Lease liability - current, Lease liability - long term