Summary of Significant Accounting Policies - Additional Information (Details) - USD ($)		1 Months Ended	12 Months Ended
	Nov. 16, 2020	Dec. 31, 2020	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2018	Sep. 05, 2018
Summary of Significant Accounting Policies [Line Items]
Depreciation, Depletion and Amortization			$ 87,000	$ 201,000
Cash and Cash Equivalents, at Carrying Value.		$ 6,227,000	$ 67,325,000	6,227,000
Equity Method Investment, Ownership Percentage			83.00%
Accrued Liabilities			$ 700,000
Prepaid Expense		500,000	500,000	500,000
Effect of Warrant exercise price adjustment		900,000	0	880,000
Net Loss Attributable to Non-controlling Interest			$ (1,000)	$ (73,000)
Preferred Stock Shares Converted	1.38		3,973	3,665
Right of use asset		279,000	$ 1,383,000	$ 279,000
Operating Lease Liability		287,000	124,000	287,000
Preferred stock price adjustment			7,402,000	$ 0
Series A and Series B Preferred Stock [Member]
Summary of Significant Accounting Policies [Line Items]
Net Loss Attributable to Non-controlling Interest			100,000
Series B Preferred Stock [Member]
Summary of Significant Accounting Policies [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount				3,454,783
Preferred stock accrued dividends			1,496,000	$ 1,380,000
Accretion of preferred discount	$ 900,000	1,400,000	1,500,000	$ 1,400,000
Series A Preferred Stock [Member]
Summary of Significant Accounting Policies [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount				678,258
Preferred stock accrued dividends			24,000	$ 254,000
Effect of Warrant exercise price adjustment				1,000,000.0
Accretion of Preferred Stock Deemed Dividend				300,000
Accretion of preferred discount			100,000		$ 6,900,000
Preferred stock price adjustment			$ 7,402,000	$ 0
Warrant [Member]
Summary of Significant Accounting Policies [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount			6,344,966	18,000,713
Options [Member]
Summary of Significant Accounting Policies [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount			6,255,275	3,997,418
Money Market Accounts [Member]
Summary of Significant Accounting Policies [Line Items]
Cash and Cash Equivalents, at Carrying Value.		$ 114,000,000	$ 193,000,000	$ 114,000,000
SYN Biomics [Member]
Summary of Significant Accounting Policies [Line Items]
Equity Method Investment, Ownership Percentage			100.00%			88.50%
Noncontrolling Interest, Ownership Percentage by Parent						11.50%
Net Loss Attributable to Non-controlling Interest				$ 2,800,000