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Stock-Based Compensation (Details 1) - Stock Option [Member] - USD ($)
3 Months Ended 12 Months Ended
Mar. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Options, Beginning Balance 938,982 359,076  
Options, Granted 0 671,500  
Options, Exercised 0 0  
Options, Expired (16,954) (78,667)  
Options, Forfeited (28,661) (12,927)  
Options, Ending Balance 893,367 938,982 359,076
Options, Exercisable 265,619    
Weighted Average Exercise Price, Beginning Balance $ 15.18 $ 53.93  
Weighted Average Exercise Price, Granted 0 0.69  
Weighted Average Exercise Price, Exercised 0 0  
Weighted Average Exercise Price, Expired 91.53 67.02  
Weighted Average Exercise Price, Forfeited 11.40 23.72  
Weighted Average Exercise Price, Ending Balance 13.85 $ 15.18 $ 53.93
Weighted Average Exercise Price, Exercisable $ 42.91    
Weighted Average Remaining Contractual Life, Balance Outstanding 5 years 10 months 24 days 6 years 2 months 8 days 4 years 7 months 6 days
Weighted Average Remaining Contractual Life, Exercisable 4 years 1 month 27 days    
Aggregate Intrinsic Value, Exercised $ 0 $ 0  
Aggregate Intrinsic Value, Ending Balance 0 0 $ 1,800
Aggregate Intrinsic Value, Exercisable   0  
Grant date fair value of options granted $ 0 $ 301,000  
Weighted average grant date fair value $ 0 $ 0.45