Stock-Based Compensation and Warrants (Details 3)	12 Months Ended
	Dec. 31, 2018 $ / shares shares
Range of Exercise Price 0.00-40.00 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options Outstanding, Range of Exercise Price Lower	$ 0.00
Options Outstanding, Range of Exercise Price Upper	$ 40.00
Options Outstanding, Options | shares	811,214
Options Outstanding, Weighted Average Exercise Price	$ 4.63
Options Outstanding, Weighted Average Remaining Contractual Life	6 years 7 months 13 days
Options Exercisable, Options | shares	94,094
Options Exercisable, Weighted Average Exercise Price	$ 24.55
Options Exercisable, Weighted Average Remaining Contractual Life	4 years 9 months 29 days
Range of Exercise Price 41.00-70.00 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options Outstanding, Range of Exercise Price Lower	$ 41.00
Options Outstanding, Range of Exercise Price Upper	$ 70.00
Options Outstanding, Options | shares	22,370
Options Outstanding, Weighted Average Exercise Price	$ 55.10
Options Outstanding, Weighted Average Remaining Contractual Life	2 years 3 months 18 days
Options Exercisable, Options | shares	22,291
Options Exercisable, Weighted Average Exercise Price	$ 55.13
Options Exercisable, Weighted Average Remaining Contractual Life	2 years 3 months 18 days
Range Of Exercise Price 71.09-102.00 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options Outstanding, Range of Exercise Price Lower	$ 71.00
Options Outstanding, Range of Exercise Price Upper	$ 102.00
Options Outstanding, Options | shares	105,398
Options Outstanding, Weighted Average Exercise Price	$ 87.84
Options Outstanding, Weighted Average Remaining Contractual Life	3 years 7 months 24 days
Options Exercisable, Options | shares	104,683
Options Exercisable, Weighted Average Exercise Price	$ 87.86
Options Exercisable, Weighted Average Remaining Contractual Life	3 years 7 months 24 days