Stock-Based Compensation and Warrants (Tables)

12 Months Ended

Dec. 31, 2018

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Share-based Compensation Arrangement by Share-based Payment Award Options and Warrants Vested and Expected to Vest Outstanding and Exercisable [Table Text Block]

	Year ended December 31,
	2018			2017
Exercise price	$	0.69		$	18.2 – $30.45
Expected dividends		0	%		0	%
Expected volatility		86	%		83% – 96	%
Risk free interest rate		2.75	%		1.67% – 2.28	%
Expected life of option		4  years			4-7 years

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

A summary of stock option activities for the years ended December 31, 2018 and 2017, is as follows:

	Options			Weighted   Average Exercise  Price		Weighted Average Remaining Contractual Life		Aggregate Intrinsic   Value
Balance - December 31, 2016		332,561		$	61.87		5.49 years	$	194,355
Granted		90,286		$	20.12
Exercised		(11,966	)	$	13.89			$	163,050
Expired		(19,091	)	$	77.46
Forfeited		(32,714	)	$	42.21
Balance - December 31, 2017		359,076		$	53.93		4.60 years	$	1,800
Granted		671,500		$	0.69
Exercised		-		$	-			$	-
Expired		(78,667	)	$	67.02
Forfeited		(12,927	)	$	23.72
Balance -December 31, 2018 - outstanding		938,982		$	15.18		6.19 years	$	-
Balance -  December 31, 2018 - exercisable		221,068		$	57.61		4.01 years	$	-
Grant date fair value of options granted -  December 31, 2018				$	301,000
Weighted average grant date fair value - December 31, 2018				$	0.45
Grant date fair value of options granted - December 31, 2017				$	1,164,732
Weighted average grant date fair value - December 31, 2017				$	0.37

Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding and Exercisable [Table Text Block]

The options outstanding and exercisable at December 31, 2018 are as follows:

Options Outstanding								Options Exercisable
Range of Exercise Price		Options		Weighted Average Exercise Price		Weighted Average Remaining Contractual Life		Options		Weighted Average Exercise Price		Weighted Average Remaining Contractual Life
$	0.00 – $40.00		811,214	$	4.63		6.62 years		94,094	$	24.55		4.83 years
	41.00 – $70.00		22,370		55.10		2.30 years		22,291		55.13		2.30 years
$	71.00 – $102.00		105,398	$	87.84		3.65 years		104,683	$	87.86		3.65 years

Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]

The assumptions used by the Company are summarized in the following table:

	Issuance Date
Closing stock price	$	0.88
Expected dividends		0	%
Expected volatility		90	%
Risk free interest rate		3.01	%
Expected life of warrant (years)		5.00

The assumptions used by the Company are summarized in the following table:

				Series A						Series B
	December 31, 2018			December 31, 2017			November 18,  2016			November 18, 2016
Closing stock price	$	0.56		$	17.85		$	31.15		$	31.15
Expected dividends		0	%		0	%		0	%		0	%
Expected volatility		92.5	%		80	%		85	%		85	%
Risk free interest rate		2.50	%		1.97	%		1.58	%		0.81	%
Expected life of warrant		1.9 years			2.9 years			4.0 years			1.1 years

	December 31, 2018			December 31, 2017			October 10, 2014
Closing stock price	$	0.56		$	17.85		$	61.25
Expected dividends		0	%		0	%		0	%
Expected volatility		110	%		80	%		95	%
Risk free interest rate		2.60	%		1.86	%		1.39	%
Expected life of warrant		.79 years			1.79 years			5.0 years

The assumptions used by the Company are summarized in the following table:

Closing stock price	$	18.55
Expected dividends		0	%
Expected volatility		85	%
Risk free interest rate		2.42	%
Expected life of warrant (years)		4.92

Schedule Of Estimated Fair Value Of The Warrant Liability [Table Text Block]

The following table summarizes the estimated fair value of the warrant liability (in thousands):

Balance at December 31, 2016	$	14,821
Change in fair value of warrant liability		(10,738	)
Balance at December 31, 2017		4,083
Change in fair value of warrant liability		(4,083	)
Balance at December 31, 2018	$	0

Schedule of Warrant Activity [Table Text Block]

A summary of all warrant activity for the Company for the years ended December 31, 2018 and 2017 is as follows:

	Number of Warrants			Weighted Average Exercise Price
Balance at December 31, 2016		1,638,333		$	56.00
Granted		-			-
Exercised		-			-
Forfeited		(723,195	)		60.20
Balance at December 31, 2017		915,138			52.50
Granted		18,000,713			1.38
Exercised		-			-
Forfeited		-			-
Balance at December 31, 2018		18,915,851		$	3.85

Schedule of Warrant Outstanding and Exercisable [Table Text Block]

A summary of all outstanding and exercisable warrants as of December 31, 2018 is as follows:

Exercise Price		Warrants Outstanding		Warrants Exercisable		Weighted Average Remaining Contractual Life
$	1.38		17,999,999		17,999,999		4.78 years
	18.20		714		714		3.99 years
	50.05		714,286		714,286		1.88 years
	61.25		200,852		200,852		0.78 years
$	52.48		18,915,851		18,915,851		4.63 years