<SEC-DOCUMENT>0001144204-18-025776-index.html : 20180507
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<ACCEPTANCE-DATETIME>20180507172851
ACCESSION NUMBER:		0001144204-18-025776
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		11
FILED AS OF DATE:		20180507
DATE AS OF CHANGE:		20180507

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Synthetic Biologics, Inc.
		CENTRAL INDEX KEY:			0000894158
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				133808303
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-224728
		FILM NUMBER:		18812317

	BUSINESS ADDRESS:	
		STREET 1:		617 DETROIT STREET, SUITE 100
		CITY:			ANN ARBOR
		STATE:			MI
		ZIP:			48104
		BUSINESS PHONE:		(734) 332-7800

	MAIL ADDRESS:	
		STREET 1:		9605 MEDICAL CENTER DRIVE
		STREET 2:		SUITE 270
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADEONA PHARMACEUTICALS, INC.
		DATE OF NAME CHANGE:	20081027

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PIPEX PHARMACEUTICALS, INC.
		DATE OF NAME CHANGE:	20061214

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SHEFFIELD PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19970730
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Document 1 - file: tv493141_s3.htm

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<DOCUMENT>
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<FILENAME>tv493141_ex4-2.htm
<DESCRIPTION>EXHIBIT 4.2
<TEXT>
Document 2 - file: tv493141_ex4-2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.3
<SEQUENCE>3
<FILENAME>tv493141_ex4-3.htm
<DESCRIPTION>EXHIBIT 4.3
<TEXT>
Document 3 - file: tv493141_ex4-3.htm

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<FILENAME>tv493141_ex5-1a.htm
<DESCRIPTION>EXHIBIT 5.1(A)
<TEXT>
Document 4 - file: tv493141_ex5-1a.htm

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<TYPE>EX-5.1B
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<FILENAME>tv493141_ex5-1b.htm
<DESCRIPTION>EXHIBIT 5.1(B)
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Document 5 - file: tv493141_ex5-1b.htm

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<FILENAME>tv493141_ex12-1.htm
<DESCRIPTION>EXHIBIT 12.1
<TEXT>
Document 6 - file: tv493141_ex12-1.htm

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<SEQUENCE>7
<FILENAME>tv493141_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 7 - file: tv493141_ex23-1.htm

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Document 9 - file: tv493141_img02.jpg

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Document 10 - file: tv493141_logo01.jpg

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