Consolidated Statements of (Deficit) Equity - USD ($) $ in Thousands	Total	Common Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Noncontrolling Interest [Member]
Balance at Dec. 31, 2014	$ 9,556	$ 72	$ 110,526	$ (101,042)	$ 0
Balance (in shares) at Dec. 31, 2014		72,513,144
Stock-based compensation	3,198	$ 0	3,198	0	0
Issuance of common stock, net of issuance costs	42,643	$ 16	42,627	0	0
Issuance of common stock, net of issuance costs (in shares)		15,333,333
Stock issued for milestone payments	1,350	$ 2	1,348	0	0
Stock issued for milestone payments (in Shares)		2,005,321
Stock issued for exclusive channel collaboration agreement	3,000	$ 1	2,999	0	0
Stock issued for exclusive channel collaboration agreement (in shares)		937,500
Stock issued for exercise of stock options	41	$ 0	41	0	0
Stock issued for exercise of stock options (in shares)		35,006
Stock issued for cashless exercise of warrants	0	$ 0	0	0	0
Stock issued for cashless exercise of warrants (in shares)		2,448
Net Loss	(43,737)	$ 0	0	(43,737)	0
Non-controlling interest	(1,048)	0	0	0	(1,048)
Balance at Dec. 31, 2015	15,003	$ 91	160,739	(144,779)	(1,048)
Balance (in shares) at Dec. 31, 2015		90,826,752
Stock-based compensation	4,009	$ 0	4,009	0	0
Issuance of common stock, net of issuance costs	24,384	$ 25	24,359	0	0
Issuance of common stock, net of issuance costs (in shares)		25,000,000
Fair value of warrants issued with financing	(15,667)	$ 0	(15,667)	0	0
Stock issued under “at-the-market” offering	1,509	$ 1	1,508	0	0
Stock issued under “at-the-market” offering (in shares)		900,628
Stock issued for exercise of stock options	814	$ 0	814	0	0
Stock issued for exercise of stock options (in shares)		445,334
Net Loss	(27,255)	$ 0	0	(27,255)	0
Non-controlling interest	(548)	0	0	0	(548)
Balance at Dec. 31, 2016	2,249	$ 117	175,762	(172,034)	(1,596)
Balance (in shares) at Dec. 31, 2016		117,172,714
Stock-based compensation	3,409	$ 0	3,409	0	0
Stock issued under “at-the-market” offering	6,358	$ 12	6,346	0	0
Stock issued under “at-the-market” offering (in shares)		10,975,399
Stock issued for exercise of stock options	166	$ 0	166	0	0
Stock issued for exercise of stock options (in shares)		418,773
Series A preferred stock beneficial conversion feature discount	0	$ 0	6,889	(6,889)	0
Series A preferred stock issue costs	(27)	0	(27)	0	0
Series A preferred stock dividends	(73)	0	0	(73)	0
Net Loss	(15,174)	0	0	(15,174)	0
Non-controlling interest	(318)	0	0	0	(318)
Balance at Dec. 31, 2017	$ (3,410)	$ 129	$ 192,545	$ (194,170)	$ (1,914)
Balance (in shares) at Dec. 31, 2017		128,566,886