License, Collaborative and Employment Agreements and Commitments (Details Textual) - USD ($)						1 Months Ended									12 Months Ended
	Dec. 04, 2017	Dec. 04, 2015	Aug. 10, 2015	Dec. 05, 2013	Oct. 05, 2012	Nov. 30, 2017	Jan. 17, 2017	Aug. 31, 2015	Aug. 29, 2015	Apr. 28, 2015	Apr. 17, 2014	Dec. 19, 2012	Nov. 28, 2012	Feb. 29, 2012	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2012
License, Collaborative and Employment Agreements and Commitments [Line Items]
Line of Credit Facility, Periodic Payment, Interest															$ 381,150
Research and Development Expense															18,784,000	$ 29,109,000	$ 32,906,000
Operating Leases, Rent Expense															199,000	145,000	108,000
Officers Compensation											$ 385,000			$ 348,000			385,000
Operating Leases, Future Minimum Payments Due, Next Twelve Months															$ 292,000
Payments for Fees						$ 5,500,000
Payments to Acquire in Process Research and Development																643,000	$ 424,000
Exchange percentage of unregistered common stock															50.00%
Proceeds from (Repurchase of) Equity, Total															$ 3,000,000	3,000,000
Options To Be Received Common Stock Shares															2,000,000
Operating Annual Lease Payments																$ 285,843
Stock Purchase Agreement [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Conversion of Stock, Shares Converted									1,350,000
Conversion of Stock, Shares Issued								1,350,000	1,350,000
Channel Collaboration Agreement [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Shares, Issued			937,500
Stock Issued			$ 3,000,000
Mark Pimentel [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Common stock Outstanding Percentage															0.00%
Licensing Agreements [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Payments for Fees				$ 150,000
Stock Issued During Period, Shares, New Issues				334,911
Patents [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Payments for Fees				$ 220,000
Riley Employment Agreement [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Officers Compensation	$ 200,000
Deferred Compensation Arrangement with Individual, Compensation Expense		$ 550,000					$ 385,000								$ 188,927
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage		75.00%					75.00%
Shallcross Employment Agreement [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Cash Payment for License Agreement															8,000
Deferred Compensation Arrangement with Individual, Compensation Expense										$ 315,000
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage										75.00%
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross										900,000
Jeffrey Riley [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value														1,700,000
Officers Compensation														$ 750,000
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage																	75.00%
Steven A. Shallcross [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value																	$ 1,900,000
Deferred Compensation Arrangement with Individual, Compensation Expense															346,500
Intrexon [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Research and Development Expense																		$ 7,800,000
Milestone Payment			27,000,000
Stock Issued During Period, Shares, Acquisitions					3,552,210
Shares Issued, Price Per Share					$ 0.001
Milestone Payment upon First Dosing			$ 2,000,000												2,000,000
Intrexon [Member] | Minimum [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Royalty Revenue, Total															100,000,000
Intrexon [Member] | Maximum [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Royalty Revenue, Total															$ 750,000,000
Prev Abr Llc [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Additional Cash Payment for License Agreement													$ 235,000
Unregistered Shares Issued to License Agreement													625,000
Additional Consideration Payable													50% in cash and 50% in our stock
Options To Be Received Common Stock Shares																	655,321
Cedars-Sinai Medical Center [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Common stock Outstanding Percentage															0.00%
Office Space In Ann Arbor [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Operating Leases, Future Minimum Payments Due, Next Twelve Months																		40,000
Office Space In Rockville [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Operating Annual Lease Payments																		$ 142,172
December 31, 2014 [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Operating Leases, Future Minimum Payments Due, Next Twelve Months												$ 50,000
December 31, 2015 [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Operating Leases, Future Minimum Payments Due, Next Twelve Months												25,000
Phase I Clinical Trials [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Milestone Payment												50,000
Phase III Clinical Trials [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Milestone Payment												100,000
NDA Submission In US [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Milestone Payment												250,000			$ 2,500,000
European Medicines Agency Approval [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Milestone Payment												100,000
Regulatory Approval In Asian Country [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Milestone Payment												100,000
First Year [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Research Agreement Fixed Fee												303,287
Second Year [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Research Agreement Fixed Fee												316,438
Third Year [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items]
Research Agreement Fixed Fee												$ 328,758