Stock-Based Compensation and Warrants (Details 1) - Stock Option [Member] - USD ($)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options, Granted	3,159,177	3,861,425	3,781,666
Options, Exercised	(418,773)	(445,334)	(35,008)
Options, Expired	(667,628)	(338,529)	(483,332)
Options, Forfeited	(1,144,905)	(383,265)	(302,502)
Options, Ending Balance	12,564,098	11,636,227	8,941,930	5,981,106
Options, Exercisable	7,805,796
Weighted Average Exercise Price, Granted	$ 0.59	$ 0.98	$ 2.37
Weighted Average Exercise Price, Exercised	0.40	1.83	1.16
Weighted Average Exercise Price, Expired	2.21	1.96	2.48
Weighted Average Exercise Price, Forfeited	1.20	2.26	1.91
Weighted Average Exercise Price, Ending Balance	1.55	$ 1.77	$ 2.14	$ 2.01
Weighted Average Exercise Price, Exercisable	$ 1.96
Weighted Average Remaining Contractual Life, Balance Outstanding	4 years 7 months 6 days	5 years 5 months 26 days	5 years 8 months 1 day	5 years 9 months 18 days
Weighted Average Remaining Contractual Life, Exercisable	3 years 5 months 5 days
Aggregate Intrinsic Value, Exercised	$ 163,050	$ 137,488	$ 44,000
Aggregate Intrinsic Value, Ending Balance	1,800	194,355	$ 2,900,000	$ 685,000
Aggregate Intrinsic Value, Exercisable	1,800
Grant date fair value of options granted	$ 1,164,732	$ 3,091,000
Weighted average grant date fair value	$ 0.37	$ 0.8