Consolidated Statements of Equity - USD ($) $ in Thousands	Total	Common Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Noncontrolling Interest [Member]
Balance at Dec. 31, 2013	$ 15,230	$ 58	$ 96,430	$ (81,258)	$ 0
Balance (in shares) at Dec. 31, 2013		58,214,326
Stock-based compensation	2,459	$ 0	2,459	0	0
Issuance of common stock, net of issuance costs	11,647	$ 14	11,633	0	0
Issuance of common stock, net of issuance costs (in shares)		14,059,616
Issuance of common stock for exercise of stock options	4	$ 0	4	0	0
Issuance of common stock for exercise of stock options (in shares)		6,583
Issuance of common stock for cashless exercise of warrants	0	$ 0	0	0	0
Issuance of common stock for cashless exercise of warrants (in shares)		232,619
Net Loss	(19,784)	$ 0	0	(19,784)	0
Non-controlling interest	0
Balance at Dec. 31, 2014	9,556	$ 72	110,526	(101,042)	0
Balance (in shares) at Dec. 31, 2014		72,513,144
Stock-based compensation	3,198	$ 0	3,198	0	0
Issuance of common stock, net of issuance costs	42,643	$ 16	42,627	0	0
Issuance of common stock, net of issuance costs (in shares)		15,333,333
Stock issued for milestone payments	1,350	$ 2	1,348	0	0
Stock issued for milestone payments (in Shares)		2,005,321
Issuance of common stock for exclusive channel collaboration agreement	3,000	$ 1	2,999	0	0
Issuance of common stock for exclusive channel collaboration agreement (in shares)		937,500
Issuance of common stock for exercise of stock options	41	$ 0	41	0	0
Issuance of common stock for exercise of stock options (in shares)		35,006
Issuance of common stock for cashless exercise of warrants	0	$ 0	0	0	0
Issuance of common stock for cashless exercise of warrants (in shares)		2,446
Net Loss	(43,737)	$ 0	0	(43,737)	0
Non-controlling interest	(1,048)	0	0	0	(1,048)
Balance at Dec. 31, 2015	15,003	$ 91	160,739	(144,779)	(1,048)
Balance (in shares) at Dec. 31, 2015		90,826,752
Stock-based compensation	4,009	$ 0	4,009	0	0
Issuance of common stock, net of issuance costs	24,384	$ 25	24,359	0	0
Issuance of common stock, net of issuance costs (in shares)		25,000,000
Fair Value of warrants issued with common stock	(15,667)	$ 0	(15,667)	0	0
Stock issued under "at the market" offering	1,509	$ 1	1,508	0	0
Stock issued under "at the market" offering (in shares)		900,628
Issuance of common stock for exercise of stock options	814	$ 0	814	0	0
Issuance of common stock for exercise of stock options (in shares)		445,334
Net Loss	(27,255)	$ 0	0	(27,255)	0
Non-controlling interest	(548)	0	0	0	(548)
Balance at Dec. 31, 2016	$ 2,249	$ 117	$ 175,762	$ (172,034)	$ (1,596)
Balance (in shares) at Dec. 31, 2016		117,172,714