Consolidated Statements of Equity - USD ($) $ in Thousands	Total	Common Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Noncontrolling Interest [Member]
Balance at Dec. 31, 2012	$ 13,028	$ 44	$ 81,925	$ (68,941)	$ 0
Balance (in shares) at Dec. 31, 2012		44,362,748
Stock-based compensation	1,669	$ 0	1,669	0	0
Issuance of common stock, net of issuance costs	12,193	$ 13	12,180	0	0
Issuance of common stock, net of issuance costs (in shares)		13,225,000
Issuance of common stock for exercise of stock options	232	$ 1	231	0	0
Issuance of common stock for exercise of stock options (in shares)		291,667
Issuance of common stock for license agreement	425	$ 0	425	0	0
Issuance of common stock for license agreement (in shares)		334,911
Issuance of stock	1	$ 0	0	0	1
Issuance of stock (in shares)		0
Net loss	(12,317)	$ 0	0	(12,317)	(1)
Non-controlling interest	(1)
Balance at Dec. 31, 2013	15,230	$ 58	96,430	(81,258)	0
Balance (in shares) at Dec. 31, 2013		58,214,326
Stock-based compensation	2,459	$ 0	2,459	0	0
Issuance of common stock, net of issuance costs	11,647	$ 14	11,633	0	0
Issuance of common stock, net of issuance costs (in shares)		14,059,616
Issuance of common stock for exercise of stock options	4	$ 0	4	0	0
Issuance of common stock for exercise of stock options (in shares)		6,583
Issuance of common stock for cashless exercise of warrants	0	$ 0	0	0	0
Issuance of common stock for cashless exercise of warrants (in shares)		232,619
Net loss	(19,784)	$ 0	0	(19,784)	0
Non-controlling interest	0
Balance at Dec. 31, 2014	9,556	$ 72	110,526	(101,042)	0
Balance (in shares) at Dec. 31, 2014		72,513,144
Stock-based compensation	3,198	$ 0	3,198	0	0
Issuance of common stock, net of issuance costs	42,643	$ 16	42,627	0	0
Issuance of common stock, net of issuance costs (in shares)		15,333,333
Stock issued for milestone payments	1,350	$ 2	1,348	0	0
Stock issued for milestone payments (in Shares)		2,005,321
Issuance of common stock for exclusive channel collaboration agreement	3,000	$ 1	2,999	0	0
Issuance of common stock for exclusive channel collaboration agreement (in shares)		937,500
Issuance of common stock for exercise of stock options	41	$ 0	41	0	0
Issuance of common stock for exercise of stock options (in shares)		35,008
Issuance of common stock for cashless exercise of warrants	0	$ 0	0	0	0
Issuance of common stock for cashless exercise of warrants (in shares)		2,446
Net loss	(43,737)	$ 0	0	(43,737)	0
Non-controlling interest	(1,048)	0	0	0	(1,048)
Balance at Dec. 31, 2015	$ 15,003	$ 91	$ 160,739	$ (144,779)	$ (1,048)
Balance (in shares) at Dec. 31, 2015		90,826,752