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Selected Quarterly Financial Data (Unaudited) (Tables)
 12 Months Ended
Dec. 31, 2015
Quarterly Financial Information Disclosure [Abstract]  
Schedule of Quarterly Financial Information [Table Text Block]
 
Quarter Ended
  
 
March 31,
2015
 
June 30,
2015
 
September 30,
2015
 
December 31,
2015
Loss from operations
 
$
(8,207
) 
 
$
(9,730
) 
 
$
(11,650
) 
 
$
(11,393
) 
Net loss
 
$
(12,359
) 
 
$
(13,623
) 
 
$
(7,507
) 
 
$
(11,296
) 
Net loss per share – basic
 
$
(0.17
) 
 
$
(0.19
) 
 
$
(0.08
) 
 
$
(0.12
) 
Net loss per share – dilutive
 
$
(0.17
) 
 
$
(0.19
) 
 
$
(0.12
) 
 
$
(0.12
) 
Weighted average common share – basic
 
 
72,673,959
 
 
 
72,736,829
 
 
 
85,974,751
 
 
 
90,810,629
 
Weighted average common share – dilutive
 
 
72,673,959
 
 
 
72,736,829
 
 
 
87,585,103
 
 
 
90,810,629
 
 
 
 
Quarter Ended
  
 
March 31,
2014
 
June 30,
2014
 
September 30,
2014
 
December 31,
2014
Loss from operations
 
$
(3,839
) 
 
$
(4,651
) 
 
$
(4,911
) 
 
$
(7,101
) 
Net loss
 
$
(3,838
) 
 
$
(4,556
) 
 
$
(4,910
) 
 
$
(6,480
) 
Net loss per share – basic and dilutive
 
$
(0.07
) 
 
$
(0.08
) 
 
$
(0.08
) 
 
$
(0.10
) 
Weighted average common share – basic and dilutive
 
 
58,324,260
 
 
 
58,543,528
 
 
 
58,543,528
 
 
 
65,483,336