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Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Cash Flows From Operating Activities:    
Net Loss $ (12,358)us-gaap_ProfitLoss $ (3,838)us-gaap_ProfitLoss
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 827us-gaap_ShareBasedCompensation 362us-gaap_ShareBasedCompensation
Stock issued for milestone payments 350syn_StockIssuedForMilestonePayments 0syn_StockIssuedForMilestonePayments
Change in fair value of warrant liabilities 4,152us-gaap_FairValueAdjustmentOfWarrants 0us-gaap_FairValueAdjustmentOfWarrants
Depreciation 8us-gaap_Depreciation 3us-gaap_Depreciation
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (26)us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets 259us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
Deposits and other assets (12)syn_IncreaseDecreaseInDepositsAndOtherAssets (2)syn_IncreaseDecreaseInDepositsAndOtherAssets
Accounts payable 563us-gaap_IncreaseDecreaseInAccountsPayable 631us-gaap_IncreaseDecreaseInAccountsPayable
Accrued liabilities 1,348us-gaap_IncreaseDecreaseInAccruedLiabilities 0us-gaap_IncreaseDecreaseInAccruedLiabilities
Accrued employee benefits (310)us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities (885)us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities
Net Cash Used In Operating Activities (5,458)us-gaap_NetCashProvidedByUsedInOperatingActivities (3,470)us-gaap_NetCashProvidedByUsedInOperatingActivities
Cash Flows From Investing Activities:    
Purchases of property and equipment (18)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (4)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment
Net Cash Used In Investing Activities (18)us-gaap_NetCashProvidedByUsedInInvestingActivities (4)us-gaap_NetCashProvidedByUsedInInvestingActivities
Cash Flows From Financing Activities:    
Proceeds from issuance of common stock for stock option exercises 0syn_ProceedsFromIssuanceOfCommonStockForStockOptionAndWarrantsExercises 4syn_ProceedsFromIssuanceOfCommonStockForStockOptionAndWarrantsExercises
Net Cash Provided By Financing Activities 0us-gaap_NetCashProvidedByUsedInFinancingActivities 4us-gaap_NetCashProvidedByUsedInFinancingActivities
Net decrease in cash (5,476)us-gaap_CashPeriodIncreaseDecrease (3,470)us-gaap_CashPeriodIncreaseDecrease
Cash at beginning of period 17,525us-gaap_CashAndCashEquivalentsAtCarryingValue 14,625us-gaap_CashAndCashEquivalentsAtCarryingValue
Cash at end of period 12,049us-gaap_CashAndCashEquivalentsAtCarryingValue 11,155us-gaap_CashAndCashEquivalentsAtCarryingValue
Supplemental disclosures of cash flow information:    
Cash paid for interest 0us-gaap_InterestPaid 0us-gaap_InterestPaid
Cash paid for taxes $ 0us-gaap_IncomeTaxesPaid $ 0us-gaap_IncomeTaxesPaid