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Consolidated Statements of Operations (USD $)
In Thousands, except Share data, unless otherwise specified
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Operating Costs and Expenses:      
General and administrative $ 6,013us-gaap_GeneralAndAdministrativeExpense $ 5,832us-gaap_GeneralAndAdministrativeExpense $ 5,012us-gaap_GeneralAndAdministrativeExpense
Research and development 14,489us-gaap_ResearchAndDevelopmentExpense 6,507us-gaap_ResearchAndDevelopmentExpense 12,287us-gaap_ResearchAndDevelopmentExpense
Total Operating Costs and Expenses 20,502us-gaap_OperatingExpenses 12,339us-gaap_OperatingExpenses 17,299us-gaap_OperatingExpenses
Loss from Operations (20,502)us-gaap_OperatingIncomeLoss (12,339)us-gaap_OperatingIncomeLoss (17,299)us-gaap_OperatingIncomeLoss
Other Income (Expense):      
Change in fair value of warrant liability 620us-gaap_FairValueAdjustmentOfWarrants 0us-gaap_FairValueAdjustmentOfWarrants 0us-gaap_FairValueAdjustmentOfWarrants
Other income (expense) 95us-gaap_OtherNonoperatingIncomeExpense (12)us-gaap_OtherNonoperatingIncomeExpense (18)us-gaap_OtherNonoperatingIncomeExpense
Interest income 3us-gaap_InvestmentIncomeInterest 33us-gaap_InvestmentIncomeInterest 33us-gaap_InvestmentIncomeInterest
Total Other Income 718us-gaap_NonoperatingIncomeExpense 21us-gaap_NonoperatingIncomeExpense 15us-gaap_NonoperatingIncomeExpense
Loss from Continuing Operations (19,784)us-gaap_IncomeLossFromContinuingOperations (12,318)us-gaap_IncomeLossFromContinuingOperations (17,284)us-gaap_IncomeLossFromContinuingOperations
Income from Discontinued Operations 0us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity 0us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity 216us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity
Net Loss (19,784)us-gaap_ProfitLoss (12,318)us-gaap_ProfitLoss (17,068)us-gaap_ProfitLoss
Net Loss Attributable to Non-controlling Interest 0us-gaap_NetIncomeLossAttributableToNoncontrollingInterest (1)us-gaap_NetIncomeLossAttributableToNoncontrollingInterest 0us-gaap_NetIncomeLossAttributableToNoncontrollingInterest
Net Loss Attributable to Synthetic Biologics, Inc. and Subsidiaries $ (19,784)us-gaap_NetIncomeLoss $ (12,317)us-gaap_NetIncomeLoss $ (17,068)us-gaap_NetIncomeLoss
Net Income (Loss) Per Share - Basic and Dilutive      
Continuing operations (in dollars per share) $ (0.32)us-gaap_IncomeLossFromContinuingOperationsPerBasicAndDilutedShare $ (0.27)us-gaap_IncomeLossFromContinuingOperationsPerBasicAndDilutedShare $ (0.50)us-gaap_IncomeLossFromContinuingOperationsPerBasicAndDilutedShare
Discontinued operations (in dollars per share) $ 0us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicAndDilutedShare $ 0us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicAndDilutedShare $ 0.01us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicAndDilutedShare
Net Income (Loss) Per Share Attributable to Synthetic Biologics, Inc. and Subsidiaries (in dollars per share) $ (0.32)us-gaap_EarningsPerShareBasicAndDiluted $ (0.27)us-gaap_EarningsPerShareBasicAndDiluted $ (0.49)us-gaap_EarningsPerShareBasicAndDiluted
Weighted average number of shares outstanding during the period - Basic and Dilutive (in shares) 61,945,356us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted 45,667,813us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted 34,896,592us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted