<SEC-DOCUMENT>0001104659-21-060282-index.html : 20210503
<SEC-HEADER>0001104659-21-060282.hdr.sgml : 20210503
<ACCEPTANCE-DATETIME>20210503165200
ACCESSION NUMBER:		0001104659-21-060282
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		7
FILED AS OF DATE:		20210503
DATE AS OF CHANGE:		20210503

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Synthetic Biologics, Inc.
		CENTRAL INDEX KEY:			0000894158
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				133808303
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-255726
		FILM NUMBER:		21884315

	BUSINESS ADDRESS:	
		STREET 1:		9605 MEDICAL CENTER DRIVE
		STREET 2:		SUITE 270
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850
		BUSINESS PHONE:		(734) 332-7800

	MAIL ADDRESS:	
		STREET 1:		9605 MEDICAL CENTER DRIVE
		STREET 2:		SUITE 270
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADEONA PHARMACEUTICALS, INC.
		DATE OF NAME CHANGE:	20081027

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PIPEX PHARMACEUTICALS, INC.
		DATE OF NAME CHANGE:	20061214

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SHEFFIELD PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19970730
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3
<SEQUENCE>1
<FILENAME>tm2114499d1_s3.htm
<DESCRIPTION>S-3
<TEXT>
Document 1 - file: tm2114499d1_s3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.4
<SEQUENCE>2
<FILENAME>tm2114499d1_ex4-4.htm
<DESCRIPTION>EXHIBIT 4.4
<TEXT>
Document 2 - file: tm2114499d1_ex4-4.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1(A)
<SEQUENCE>3
<FILENAME>tm2114499d1_ex5-1a.htm
<DESCRIPTION>EXHIBIT 5.1(A)
<TEXT>
Document 3 - file: tm2114499d1_ex5-1a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1(B)
<SEQUENCE>4
<FILENAME>tm2114499d1_ex5-1b.htm
<DESCRIPTION>EXHIBIT 5.1(B)
<TEXT>
Document 4 - file: tm2114499d1_ex5-1b.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>5
<FILENAME>tm2114499d1_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 5 - file: tm2114499d1_ex23-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>tm2114499d1_s3img001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: tm2114499d1_s3img001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>tm2114499d1_5-1aimg001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 7 - file: tm2114499d1_5-1aimg001.jpg

</DOCUMENT>
</SEC-DOCUMENT>